Publications by authors named "Bindhu Kollivayal Madhavan"
Int J Cancer
October 2024
Article Synopsis
- The ARP2/3 complex plays a crucial role in the organization of the actin cytoskeleton and the formation of structures called lamellipodia, which are important in the progression of pancreatic ductal adenocarcinoma (PDAC).
- This study investigates how the ARP2/3 complex affects cancer-associated fibroblasts (CAFs) that contribute to PDAC advancement and patient survival, using mouse models and human cell studies.
- Results indicate that the ARP2/3 complex is vital for CAF migration and differentiation, suggesting that targeting it could be an effective new approach for treating PDAC.
