Publications by authors named "Bindhu Hosuru"

Many pathogens encode proteases that serve to antagonize the host immune system. In particular, viruses with a positive-sense single-stranded RNA genome [(+)ssRNA], including picornaviruses, flaviviruses, and coronaviruses, encode proteases that are not only required for processing viral polyproteins into functional units but also manipulate crucial host cellular processes through their proteolytic activity. Because these proteases must cleave numerous polyprotein sites as well as diverse host targets, evolution of these viral proteases is expected to be highly constrained.

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Synopsis of recent research by authors named "Bindhu Hosuru"

  • - Bindhu Hosuru’s research primarily focuses on the interplay between viral proteases and the host immune system, highlighting how certain viruses exploit their proteases to undermine host defenses.
  • - The article "Running With Scissors: Evolutionary Conflicts Between Viral Proteases and the Host Immune System" discusses the intricate role of viral proteases in processing viral proteins and manipulating key host cellular functions, particularly in (+)ssRNA viruses like picornaviruses, flaviviruses, and coronaviruses.
  • - Findings suggest that the evolutionary pressures on these viral proteases are significant, as they must efficiently cleave viral polyproteins while also targeting various host proteins, indicating a complex evolutionary "arms race" between pathogens and host immune responses.