Publications by authors named "Bincy Philip"
Bisphosphonates inhibit stellate cell activity and enhance antitumor effects of nanoparticle albumin-bound paclitaxel in pancreatic ductal adenocarcinoma.
Mol Cancer Ther
November 2014
Pancreatic stellate cells (PSC) have been recognized as the principal cells responsible for the production of fibrosis in pancreatic ductal adenocarcinoma (PDAC). Recently, PSCs have been noted to share characteristics with cells of monocyte-macrophage lineage (MML cells). Thus, we tested whether PSCs could be targeted with the nitrogen-containing bisphosphonates (NBP; pamidronate or zoledronic acid), which are potent MML cell inhibitors.
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- The study investigates the role of GPR81, a lactate receptor, in various cancer cell lines, particularly focusing on its expression in pancreatic cancer, where 94% of patient tumors showed high levels.
- Reducing GPR81 expression in pancreatic cancer cells didn't affect growth in high glucose but significantly increased cell death in low glucose conditions when lactate was present.
- The research indicates that GPR81 is crucial for cancer cell adaptation to the tumor microenvironment by regulating lactate transport, impacting tumor growth and metastasis.
Background & Aims: Obesity is a risk factor for pancreatic ductal adenocarcinoma (PDAC), but it is not clear how obesity contributes to pancreatic carcinogenesis. The oncogenic form of KRAS is expressed during early stages of PDAC development and is detected in almost all of these tumors. However, there is evidence that mutant KRAS requires an additional stimulus to activate its full oncogenic activity and that this stimulus involves the inflammatory response.
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