Remaining useful life prognostic for degrading systems with age- and state-dependent jump-diffusion processes.

The prediction of the remaining useful life (RUL) holds significant importance within the field of prognostics and health management (PHM), which may provide lifetime information about the system. The foundation for effectively estimating RUL is constructing an applicable degradation model for the system. However, the majority of existing degradation models only consider the issue of age dependence and disregard state dependence.

High-dimensional topographic organization of visual features in the primate temporal lobe.

The inferotemporal cortex supports our supreme object recognition ability. Numerous studies have been conducted to elucidate the functional organization of this brain area, but there are still important questions that remain unanswered, including how this organization differs between humans and non-human primates. Here, we use deep neural networks trained on object categorization to construct a 25-dimensional space of visual features, and systematically measure the spatial organization of feature preference in both male monkey brains and human brains using fMRI.

Topographic representation of visually evoked emotional experiences in the human cerebral cortex.

Affective neuroscience seeks to uncover the neural underpinnings of emotions that humans experience. However, it remains unclear whether an affective space underlies the discrete emotion categories in the human brain, and how it relates to the hypothesized affective dimensions. To address this question, we developed a voxel-wise encoding model to investigate the cortical organization of human emotions.

Retinoid X Receptor α Regulates DHA-Dependent Spinogenesis and Functional Synapse Formation In Vivo.

Coordinated intracellular and extracellular signaling is critical to synapse development and functional neural circuit wiring. Here, we report that unesterified docosahexaenoic acid (DHA) regulates functional synapse formation in vivo via retinoid X receptor α (Rxra) signaling. Using Rxra conditional knockout (cKO) mice and virus-mediated transient gene expression, we show that endogenous Rxra plays important roles in regulating spinogenesis and excitatory synaptic transmission in cortical pyramidal neurons.