Synthesis and protective effect of pyrazole conjugated imidazo[1,2-]pyrazine derivatives against acute lung injury in sepsis rats attenuation of NF-κB, oxidative stress, and apoptosis.

The current work was conducted to elucidate the pharmacological effect of pyrazole-conjugated imidazo[1,2-]pyrazine derivatives against acute lung injury in rats in sepsis and their mechanism of action. Various pyrazole-conjugated imidazo[1,2-]-pyrazine derivatives have been synthesized in a straightforward synthetic route. They exhibited a diverse range of inhibitory activity against NF-ĸB with ranging from 1 to 94 µmol L-1.

[The role of miR-135b-5p in inhibiting mice acute lung injury (ALI) induced by sepsis and its mechanism].

To investigate the expression status of miR-135b-5p in the sepsis induced acute lung injury (ALI) mice and its effects on inflammatory responses and cell pyroptosis in mice pulmonary tissues. The cecal ligation puncture (CLP) method was employed to construct sepsis-induced ALI mice models. The C57BL/6 mice were randomly divided into 6 groups with 8 mice in each group.