Publications by authors named "Binbin Sun"

Scaffold-guided meniscus repair and regeneration show promise for meniscus injuries. Desirable scaffold properties are key to promoting proper tissue remodeling and effective regeneration. Herein, we report an inflammation-modulating elastic decellularized extracellular matrix (ECM) scaffold and evaluate its biological performance on meniscus repair in a rabbit model.

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Electrospun membranes with biomimetic fibrous structures and high specific surfaces benefit cell proliferation and tissue regeneration but are prone to cause chronic inflammation and foreign body response. To solve these problems, we herein report an approach to functionalize electrospun membranes with antibacterial and anti-inflammatory components to modulate inflammatory responses and improve implantation outcomes. Specifically, electrospun polylactic acid (PLA)/gelatin (Gel) fibers were grafted with chitosan (CS) and ibuprofen (IBU) via carbodiimide chemistry.

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Iron-loaded diatomite (Fe-DE) was developed as the innovative material to enhance anammox granular sludge (AnGS) and mainstream anammox performance. By adding Fe-DE with the Fe:DE ratio of 1:20 and the dosage of 3 g/L, the start-up period of mainstream anammox process was shortened from 29 d to 17 d and its nitrogen removal rate was increased from 0.234 kg N/(m·d) to 0.

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In this work, a series of three-dimensional (3D) SERS substrate were successfully fabricated by assembling silver nanoparticles (AgNPs) onto a porous gelatin sponge (GS) for highly sensitive thiram residues detection in vegetables. These 3D micro-nanostructures could induce the sufficient surface plasmon resonance (SPR) effect of noble metals on their surface and achieve high enrichment of pollutant molecules. As crystal violet (CV) was used as a probe molecule, the lowest CV solution could be detected at 10 M, and the enhancement factor (EF) was calculated to be 9.

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The new-type submerged granular sludge membrane bioreactor (S-GSMBR) was constructed by installing a membrane module inside an upflow anaerobic sludge blanket. S-GSMBR achieved the fast start-up (47 d) and long-term stable operation (133 d) of mainstream Anammox process as well as the effective control of membrane fouling. The maximum nitrogen removal rate and efficiency were 0.

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Introduction: Early identification of Autism Spectrum Disorder (ASD) is critical for effective intervention. Restricted interests (RIs), a subset of repetitive behaviors, are a prominent but underutilized domain for early ASD diagnosis. This study aimed to identify objective biomarkers for ASD by integrating electroencephalography (EEG) and eye-tracking (ET) to analyze toddlers' visual attention and cortical responses to RI versus neutral interest (NI) objects.

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This study investigates the impact of β-fructofuranosidase (Bmsuc1) on the development of the silk gland in silkworms (Bombyx mori). Previous research shows that Bmsuc1 is highly expressed in the silk glands and may be involved in silk gland development and protein synthesis. However, the precise mechanism by which Bmsuc1 regulates silk gland development remains unclear.

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  • Researchers developed an injectable hydrogel using chitosan as a carrier for delivering nonsteroidal anti-inflammatory drugs, specifically loxoprofen, which improved its water solubility.
  • The hydrogel, modified through photopolymerization, showed strong cytocompatibility, effectively reducing inflammatory responses in macrophages and in a rat model.
  • The findings indicate that chitosan-drug conjugates can be used to create effective methacrylate hydrogels for sustained drug release and targeted inflammation treatment.
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  • - The study focuses on creating a carbon fiber-mediated electrospinning scaffold to repair tendon injuries, addressing the challenge of restoring the electrical signal pathway lost due to tendon rupture.
  • - This innovative scaffold, which combines strong carbon fibers with nanofiber membranes, showed superior tensile strength and supported tenocyte proliferation and adaptation to electrical stimulation, promoting tendon regeneration.
  • - Results from a rabbit model indicated that this scaffold significantly enhanced collagen fiber filling and improved the expression of important proteins related to tendon repair, suggesting that conductivity plays a crucial role in tendon healing and offering a promising method for future clinical applications.
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As a kind of unique biomimetic macromolecule, polydopamine (PDA) have prominent in-situ reduction ability and interfacial adhesion. In this work, combined with in-situ reduction ability of PDA and excellent magnetic response performance of nickel foam (NF), a strategy was designed to fabricate a series of NF@PDA@AgNPs as magnetic-responsive surface enhancement Raman scattering (SERS) substrates for highly sensitive Rhodamine B (RhB) detection in chili powder. With crystal violet (CV) as probe molecule, the detection limit of SERS substrate could achieve 10 M, and the enhancement factor was as high as to 2.

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Objective: The objective of this study is to compare the effectiveness of the Esmarch bandage and exsanguination tourniquet rings (ETRs) in blood evacuation procedures using a controlled intra-subject design involving healthy volunteers.

Methods: A total of 20 healthy adult volunteers (12 males, 8 females) were recruited from the community. Participants underwent blood evacuation procedures on both legs, using the Esmarch bandage on one leg and the ETR on the other.

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The restoration of cartilage injuries remains a formidable challenge in orthopedics, chiefly attributed to the absence of vascularization and innervation in cartilage. Decellularized extracellular matrix (dECM) derived from cartilage, following antigenic removal through decellularization processes, has exhibited remarkable biocompatibility and bioactivity, rendering it a viable candidate for cartilage repair. Additionally, extracellular vesicles (EVs) generated from cartilage have demonstrated a synergistic effect when combined with dECM, potentially mitigating the inhibitory impact on protein synthesis by phosphorylating 4ebp, thereby promoting the synthesis of cartilage-related proteins such as collagen.

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Background: Excessive intraoperative bleeding remains a challenge in limb surgeries. The exsanguination tourniquet ring has emerged as a potential solution for effective exsanguination and hemostasis. This study aims to evaluate its efficacy and safety compared to the conventional exsanguination and hemostasis approach (pneumatic tourniquet combined with Esmarch bandage).

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  • - The study investigated the effects of two types of selenium-doped carbon quantum dots (Se-CQDs1 and Se-CQDs2) on tomato plant growth and selenium enrichment, highlighting their potential as novel fertilizers in agriculture.
  • - Results showed that Se-CQDs1 significantly enhanced root growth, biomass, and fruit yield compared to Se-CQDs2 and a standard sodium selenite treatment, primarily due to up-regulation of specific genes related to water uptake and hormone synthesis.
  • - Se-CQDs1 also improved soil bacterial diversity, especially in beneficial groups like Actinobacteria, which contributes to plant growth, indicating that the method of synthesizing these nanoparticles affects their efficiency as fertilizers.
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Low activation performance is a critical issue limiting the practical application of low-cost biochar in the advanced oxidation. Given the high potential of transition metals in the persulfate activation process and abundant oxygen-containing groups of hydrochar, hydrochar derived from cobalt (Co)-modified iron (Fe)-enriched sludge was synthesized and its performance and activation mechanism for the degradation of triclosan were investigated. Co modification significantly altered the morphology of hydrochar, and the increased Co-Fe mass ratios transformed hydrochar from granular to rose-shaped lamellar and then to helical sheet structures.

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N-chloro-N-fluorobenzenesulfonylamide (CFBSA), was a novel chlorinating reagent, which exhibits potential antibacterial activities. In this study, CFBSA was confirmed as a wide-broad antimicrobial and bactericidal drug against different gram-negative bacteria, gram-positive bacteria and fungi, while it was found to have low cytotoxicity for eukaryotic cells. In addition, microorganism morphology assay and oxidative stress test was used to determine the antimicrobial mechanisms of CFBSA.

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  • The development of tumor vaccines is hindered by the difficulty in obtaining specific tumor antigens, but multivalent antigens are thought to enhance effectiveness.
  • A new multivalent mRNA vaccine (MmRV) containing three neoantigens for melanoma was created and combined with mannosylated chitosan-modified ethosomes for better transcutaneous immunization (TCI).
  • Results show that TCI patches with MmRV boost immune responses, inhibit tumor growth, and are safe for use without damaging healthy tissues, while the combination with a PDL1 blocker enhances antitumor effects significantly.
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Despite recent progress in multiple myeloma (MM) treatments, most patients will relapse and require additional treatment. Intravenous daratumumab, a human IgGκ monoclonal antibody targeting CD38, has shown good efficacy in the treatment of MM. A subcutaneous version of daratumumab was formulated to reduce the burden of intravenous infusions.

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To solve the problems of slow regeneration and mismatch of axon regeneration after peripheral nerve injury, nerve guidance conduits (NGCs) have been widely used to promote nerve regeneration. Multichannel NGCs have been widely studied to mimic the structure of natural nerve bundles. However, multichannel conduits are prone to structural instability.

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  • A study on an anammox reactor revealed that applying a magnetic field of 40 mT improved nitrogen removal rates by 16% compared to a control setup.
  • This enhancement was attributed to better mass transfer efficiency, strengthened interactions among microbial communities, and increased levels of functional genes essential for nitrogen metabolism.
  • Notably, the presence of a magnetic field promoted loose granular sludge formation and increased the abundance of Candidatus Brocadia by 13%, contributing to a stable and effective anammox process.
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As a frequently detected per- and polyfluoroalkyl substance in the environment, 6:6 perfluoroalkylhypophosphinic acid (6:6 PFPiA) is vulnerable to transformation in the liver of organisms, but the transformation in gut is still unclear. This study investigates the molecular mechanisms of 6:6 PFPiA transformation in the gut of Xenopus laevis upon a 28-day exposure in water. Before Day 16, a notable correlation (p = 0.

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Snakehead vesiculovirus (SHVV) is a negative-sense single-stranded RNA virus that infects snakehead fish. This virus leads to illness and mortality, causing significant economic losses in the snakehead aquaculture industry. The replication and spread of SHVV in cells, which requires glutamine as a nitrogen source, is accompanied by alterations in intracellular metabolites.

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Background: Small-diameter vascular grafts have become the focus of attention in tissue engineering. Thrombosis and aneurysmal dilatation are the two major complications of the loss of vascular access after surgery. Therefore, we focused on fabricating 3D printed electrospun vascular grafts loaded with tetramethylpyrazine (TMP) to overcome these limitations.

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  • The aging population is facing increased risks from bone defects, making it necessary to find effective treatments, with aerogel materials showing promise due to their ECM-like properties.
  • Research developed flexible ZnO-SiO nanofiber scaffolds that, when combined with chitosan and aspirin, demonstrated improved biocompatibility, mechanical strength, and the ability to boost bone growth and vascularization.
  • In mouse models, the new scaffolds significantly outperformed controls in promoting new bone formation, likely due to the release of beneficial components that enhance the body's healing response and reduce inflammation.
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Background: In the inflammatory milieu of diabetic chronic wounds, macrophages undergo substantial metabolic reprogramming and play a pivotal role in orchestrating immune responses. Itaconic acid, primarily synthesized by inflammatory macrophages as a byproduct in the tricarboxylic acid cycle, has recently gained increasing attention as an immunomodulator. This study aims to assess the immunomodulatory capacity of an itaconic acid derivative, 4-Octyl itaconate (OI), which was covalently conjugated to electrospun nanofibers and investigated through in vitro studies and a full-thickness wound model of diabetic mice.

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