Earth-Based Transmitters Trigger Precipitation of Inner Radiation Belt Electrons: Unveiling Observations and Modeling Results.

Human activity influence Earth's environment, including the space environment hundreds to thousands of kilometers above the Earth. One direct evidence is that the 19.8 kHz electromagnetic signals launched by the North West Cape (NWC) transmitter station in Australia produce a wisp-like energy distribution of precipitating energetic electrons in Earth's inner radiation belt, observed by many Low Earth Orbiting satellites.

CFD simulation of cannabidiol delivery through microneedle patches.

This study investigates the efficiency and influence of microneedle parameters, specifically Needle Point Angle (a) and Needle Height (h), on the diffusion of Cannabidiol (CBD) across varying skin depths. Utilizing the Latin Hypercube Sampling method, twelve distinct cases were analyzed. Observations reveal a consistent high concentration of CBD delivered the microneedle patch, with a notable decrease in concentration as the depth increases, displaying a non-linear trend.

When Artificial Intelligence Voices Human Concerns: The Paradoxical Effects of AI Voice on Climate Risk Perception and Pro-Environmental Behavioral Intention.

Artificial intelligence (AI)-enabled text-to-speech transformation has been widely employed to deliver online information in various fields. However, few studies have investigated the effect of the AI voice in environmental risk communication, especially in the field of climate change, an issue that poses a severe threat to global public health. To address this gap, the current study examines how the AI voice impacts the persuasive outcome of climate-related information and the potential mechanism that underlies this process.

Local anesthesia, epidural anesthesia and general anesthesia comparison in lumbar disc herniation: a network meta-analysis.

There were 3 major anesthesia methods for discectomy: local, epidural and general. A lot of studies has been established to compare these three methods in different aspects, however, the result is still controversial. We conducted this network meta-analysis to evaluate these methods.

Identification of ring current proton precipitation driven by scattering of electromagnetic ion cyclotron waves.

Among the most intense emissions in the Earth's magnetosphere, electromagnetic ion cyclotron (EMIC) waves are regarded as a critical candidate contributing to the precipitation losses of ring current protons, which however lacks direct multi-point observations to establish the underlying physical connection. Based upon a robust conjunction between the satellite pair of Van Allen Probe B and NOAA-19, we perform a detailed analysis to capture simultaneous enhancements of EMIC waves and ring current proton precipitation. By assuming that the ring current proton precipitation is mainly caused by EMIC wave scattering, we establish a physical model between the wave-driven proton diffusion and the ratio of precipitated-to-trapped proton count rates, which is subsequently applied to infer the intensity of EMIC waves required to cause the observed proton precipitation.

Perceived Information Overload and Unverified Information Sharing on WeChat Amid the COVID-19 Pandemic: A Moderated Mediation Model of Anxiety and Perceived Herd.

Individuals' unverified information sharing on social media, namely, sharing information without verification, is a major cause of the widespread misinformation amid the COVID-19 pandemic. The association between perceived information overload and unverified information sharing has been well documented in the cognitive overload approach. However, little is known about the underlying mechanism of this process.

Revealing the source of Jupiter's x-ray auroral flares.

Jupiter's rapidly rotating, strong magnetic field provides a natural laboratory that is key to understanding the dynamics of high-energy plasmas. Spectacular auroral x-ray flares are diagnostic of the most energetic processes governing magnetospheres but seemingly unique to Jupiter. Since their discovery 40 years ago, the processes that produce Jupiter's x-ray flares have remained unknown.

Oxidative stress induces downregulation of TP53INP2 and suppresses osteogenic differentiation of BMSCs during osteoporosis through the autophagy degradation pathway.

Oxidative stress plays an important role in the pathogenesis of osteoporosis and impaired bone formation. However, the mechanisms behind which oxidative stress represses bone formation remains unclear. TP53INP2, a target of the tumor suppressor p53, is ubiquitously expressed in various cell types including BMSCs and contributes to autophagosome formation by recruiting ubiquitinated substrates to autophagosomes for degradation.

Very-Low-Frequency transmitters bifurcate energetic electron belt in near-earth space.

Very-Low-Frequency (VLF) transmitters operate worldwide mostly at frequencies of 10-30 kilohertz for submarine communications. While it has been of intense scientific interest and practical importance to understand whether VLF transmitters can affect the natural environment of charged energetic particles, for decades there remained little direct observational evidence that revealed the effects of these VLF transmitters in geospace. Here we report a radially bifurcated electron belt formation at energies of tens of kiloelectron volts (keV) at altitudes of ~0.

Comparison of surgical outcomes of lumbar disc herniation using local anesthesia and epidural anesthesia: A meta-analysis.

We performed this meta-analysis to evaluate the effects of epidural anesthesia and local anesthesia on the surgical outcomes of lumbar disc herniation (DH).Electronic databases including PubMed, EMBASE, Cochrane Library, and the Chinese Academic Journal Full-text Database were searched to identify randomized controlled trials (RCTs) that reported on the effects of local anesthesia and epidural anesthesia in lumbar DH surgical management. Evaluation indicators included: onset time of anesthesia, patient satisfaction, and the rate of adverse effects.

Use of a locking intramedullary nail for the treatment of initial varus proximal humeral fracture: a prospective pilot study.

Objective: To evaluate the feasibility of locked intramedullary nailing, rather than locking plate fixation combined with fibular allograft augmentation, for initial varus proximal humeral fractures.

Methods: This prospective pilot study enrolled patients with initial varus proximal humeral fractures that were treated with a locking intramedullary nail. Radiography was performed to evaluate fracture healing.

Design of Multifunctional Mesosphere-Ionosphere Sounding System and Preliminary Results.

This paper describes a novel sounding system for which the functions of the medium frequency (MF) radar and the ionosonde are integrated on the same hardware platform and antenna structure, namely the middle atmosphere-ionosphere (MAI) system. Unlike the common MF radar, MAI system adopts the pseudo-random (PRN) phase-coded modulation technology, which breaks the limitation of the traditional monopulse mode. Through the pulse compression, only a small peak power is needed to achieve the signal-to-noise ratio (SNR) requirement.

Contactless treatment for scoliosis by electromagnetically controlled shape-memory alloy rods: a preliminary study in rabbits.

Purpose: To evaluate the safety and efficacy of a system aiming to correct scoliosis called "electromagnetically controlled shape-memory alloy rods" (EC-SMAR) used in a rabbit model.

Methods: We heat-treated shape-memory alloy (SMA) rods to achieve a transition temperature between 34 and 47 °C and a C-shape austenite phase. We then developed a water-cooled generator capable of generating an alternating magnetic field (100 kHz) for induction heating.

Origin of two-band chorus in the radiation belt of Earth.

Naturally occurring chorus emissions are a class of electromagnetic waves found in the space environments of the Earth and other magnetized planets. They play an essential role in accelerating high-energy electrons forming the hazardous radiation belt environment. Chorus typically occurs in two distinct frequency bands separated by a gap.

TGF-β1 reduces the oxidative stress-induced autophagy and apoptosis in rat annulus fibrosus cells through the ERK signaling pathway.

Background: The aim of this study is to explore the effects of TGF-β1 on autophagy and apoptosis induced by exogenous hydrogen peroxide (HO) in annulus fibrosus (AF) cells and possible signal pathways involved in this process.

Methods: AF cells were isolated from rat lumbar discs and subjected to different concentrations of exogenous HO (50, 100, 200 μmol/L) for different time periods (0.5, 1, 2, and 4 h).

A Novel Ionospheric Sounding Network Based on Complete Complementary Code and Its Application.

In this paper, complete complementary code (CCC) sequences are applied to a High Frequency (HF) ionospheric sounding network. Ionosondes distributed at multiple locations use the mutually orthogonal CCC sequences to conduct vertical soundings synchronously. At the same time, thanks to the omnidirectional antennas, every station can receive the oblique echoes transmitted from the others.

Production of primary metabolites in Microcystis aeruginosa in regulation of nitrogen limitation.

The aim of this work was to study the regulatory effect of nitrogen (N) deficiency on primary metabolites in Microcystis aeruginosa, and promote the utilization of the alga. Low-N and Non-N conditions, especially Non-N, reduced the cell growth and photosynthetic abilities compared to Normal-N, as N deficiency triggered the down-regulation of genes involving in the photosynthetic process. Non-N not changed lipid content, due to no up-regulation of genes that promoted lipid synthesis.

Scattering of Ultra-relativistic Electrons in the Van Allen Radiation Belts Accounting for Hot Plasma Effects.

Electron flux in the Earth's outer radiation belt is highly variable due to a delicate balance between competing acceleration and loss processes. It has been long recognized that Electromagnetic Ion Cyclotron (EMIC) waves may play a crucial role in the loss of radiation belt electrons. Previous theoretical studies proposed that EMIC waves may account for the loss of the relativistic electron population.

Newly designed anterolateral and posterolateral locking anatomic plates for lateral tibial plateau fractures: a finite element study.

Background: Lateral column tibial plateau fracture fixation with a locking screw plate has higher mechanical stability than other fixation methods. The objectives of the present study were to introduce two newly designed locking anatomic plates for lateral tibial plateau fracture and to demonstrate their characteristics of the fixation complexes under the axial loads.

Methods: Three different 3D finite element models of the lateral tibial plateau fracture with the bone plates were created.

[Corrigendum] Adenovirus-mediated overexpression of BMP-9 inhibits human osteosarcoma cell growth and migration through downregulation of the PI3K/AKT pathway.

Following the publication of this article, an interested reader drew to our attention an anomaly associated with the presentation of the western blots in Fig. 4B and C. These contained the same GAPDH control data, even though Fig.

The morphological features of different Schatzker types of tibial plateau fractures: a three-dimensional computed tomography study.

Background: Tibial plateau fractures are of great challenge to treat with open reduction and internal fixation, because fractures vary from simple to complex, with little or extensive articular involvement. Hence, recognition and comprehension of the fracture features will help orthopedic surgeons understand the injury mechanism better and manage these fractures by planning optimal surgical procedures. This study aimed to evaluate the morphological characteristics of tibial plateau fractures based on the Schatzker classification.

Hypoxia facilitates the survival of nucleus pulposus cells in serum deprivation by down-regulating excessive autophagy through restricting ROS generation.

Nucleus pulposus (NP) cells reside in a hypoxic environment in vivo, while the mechanisms of how NP cells maintain survival under hypoxia are not clear. Autophagy is an important physiological response to hypoxia and implicated in the survival regulation in most types of cells. This study was designed to investigate the role of autophagy in the survival of NP cells under hypoxia.

The responses of autophagy and apoptosis to oxidative stress in nucleus pulposus cells: implications for disc degeneration.

Background/aims: Apoptosis and autophagy are two patterns of programmed cell death which play important roles in the intervertebral disc degeneration. Oxidative stress is an important factor for the induction of programmed cell death. However, the cellular reactions linking autophagy to apoptosis of disc cells under oxidative stress have never been described.

The effect of transforming growth factor β1 on the crosstalk between autophagy and apoptosis in the annulus fibrosus cells under serum deprivation.

Autophagy and apoptosis are important in maintaining the metabolic homeostasis of intervertebral disc cells, and transforming growth factor-β1 (TGF-β1) is able to delay intervertebral disc degeneration. This study determined the effect of TGF-β1 on the crosstalk between autophagy and apoptosis in the disc cells, with the aim to provide molecular mechanism support for the prevention and treatment of disc degeneration. Annulus fibrosus (AF) cells were isolated and cultured under serum starvation.

Adenovirus-mediated overexpression of BMP-9 inhibits human osteosarcoma cell growth and migration through downregulation of the PI3K/AKT pathway.

Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily of signaling molecules and have previously been shown to be associated with the biological behavior of osteosarcoma. However, to date the effects and molecular mechanisms of BMP-9 on osteosarcoma progression are unknown. We performed real-time PCR and western blot analysis to characterize the endogenous expression of BMP-9 in osteosarcoma cell lines.