Publications by authors named "Binbin Lei"

Objective: This study aimed to investigate the independent and joint associations of accelerometer-derived sleep duration and physical activity (PA) in different intensities with the risk of incident heart failure (HF).

Methods: The study included 89,572 participants (mean age 62.2 ± 7.

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Study Objectives: This study aimed to determine the associations between accelerometer-measured sleep durations and the risks of incident cardiovascular disease (CVD) and CVD-related mortality.

Methods: A total of 92 261 participants (mean age: 62.4 ± 7.

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Background: Understanding the evolution of circadian rhythm dysfunction and psychopathology in the high-risk population has important implications for the prevention of bipolar disorder. Nevertheless, some of the previous studies on the emergence of psychopathologies and circadian dysfunction among high-risk populations were inconsistent and limited.

Aims: To examine the prevalence rates of sleep and circadian dysfunctions, mental disorders and their symptoms in the offspring of parents with (O-BD) and without bipolar disorder (O-control).

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Background: The health effects of rest-activity rhythm are of major interest to public health, but its associations with health outcomes remain elusive. We aimed to examine the associations between accelerometer-measured rest-activity rhythm amplitude and health risks among the general UK population.

Methods: We did a prospective cohort analysis of UK Biobank participants aged 43-79 years with valid wrist-worn accelerometer data.

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Evidence suggests potential links between circadian rhythm and atrial fibrillation (AF). However, whether circadian disruption can predict the onset of AF in the general population remains largely unknown. We aim to investigate the association of accelerometer-measured circadian rest-activity rhythm (CRAR, the most prominent circadian rhythm in humans) with the risk of AF, and examine joint associations and potential interactions of CRAR and genetic susceptibility with AF incidence.

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Article Synopsis
  • There is increasing research on how the timing of daily activities can enhance health, particularly regarding physical activity's impact on mortality rates.
  • A study with over 92,000 UK Biobank participants found that engaging in moderate-to-vigorous physical activity (MVPA) at any time reduces risks of all-cause, cardiovascular, and cancer-related deaths.
  • Participants who did MVPA in the midday-afternoon range (11:00-17:00) had lower mortality risks compared to those who exercised in the morning or evening, especially among older adults and those with preexisting health conditions.
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Based on engineering background that local heating of coal seam is uneven due to underground coal gasification, coal-bed gas exploitation via heat injection, spontaneous combustion of coal seam, etc., segmented heating coal sample was used to simulate coal seam under uneven heating condition, and experimental study on mechanical behaviors of coal sample after segmented heat treatment at high temperatures was conducted. Test results show that temperature at 100 °C ~ 400 °C did not reach ignition temperature of deep hard coal for the experiment and was not enough to change main ingredients of coal sample, which less affected compression strength, elastic modulus, acoustic emission behavior of coal sample.

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Background: Circadian dysregulation has long been thought to be a key component in the pathophysiology of bipolar disorder (BD). However, it remains unclear whether this dysregulation constitutes a risk factor, manifestation, or consequence of BD. This study aimed to compare dim light melatonin secretion patterns between unaffected offspring of parents with BD (OBD) and offspring of control parents (OCP).

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Background: The association between night shift work and prostate cancer is controversial. Evidence shows that genetic and environmental factors both contribute to the development of prostate cancer. It is well known that melatonin plays a protective role in prostate cancer.

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Article Synopsis
  • The study aimed to explore how different sleep patterns are linked to the risk of severe intentional self-harm (ISH) in middle-aged and older adults, using data from 499,159 participants in the UK Biobank.
  • The research found that both short and long sleep duration, as well as insomnia, significantly increased the risk of severe ISH, even after accounting for other factors like demographics and mental health.
  • The study highlights the importance of recognizing sleep issues as potential predictors of serious self-harm behaviors in older adults.
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Background: Previous research has examined the association between parents' and children's posttraumatic stress disorder symptoms (PTSS) after a variety of traumatic events. However, longitudinal parent-child dyadic studies are scarce.

Methods: Independent self-reports were collected from parent-adolescent dyads (n = 688) after the 2008 Wenchuan earthquake.

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