Pelvic floor muscle strength and influencing factors based on vaginal manometry among healthy women at different life stages: A multicentre cross-sectional study.

Objective: To assess pelvic floor muscle (PFM) strength and influencing factors among healthy women at different life stages.

Design: Multicentre cross-sectional study.

Setting: Fourteen hospitals in China.

A Lightweight Detection Method for Remote Sensing Images and Its Energy-Efficient Accelerator on Edge Devices.

Convolutional neural networks (CNNs) have been extensively employed in remote sensing image detection and have exhibited impressive performance over the past few years. However, the abovementioned networks are generally limited by their complex structures, which make them difficult to deploy with power-sensitive and resource-constrained remote sensing edge devices. To tackle this problem, this study proposes a lightweight remote sensing detection network suitable for edge devices and an energy-efficient CNN accelerator based on field-programmable gate arrays (FPGAs).

Effectiveness of Self-cut vs Mesh-Kit Titanium-Coated Polypropylene Mesh for Transvaginal Treatment of Severe Pelvic Organ Prolapse: A Multicenter Randomized Noninferiority Clinical Trial.

Importance: Transvaginal mesh (TVM) can increase the durability of vaginal surgical procedures for pelvic organ prolapse (POP) and may be indicated in certain situations despite concerns about mesh-related complications. In addition, the expense of commercial mesh kits has limited their use. The effectiveness, safety, and cost of a self-cut mesh procedure compared with a commercial mesh-kit procedure for the surgical treatment of women with POP is unclear.

MALAT1 accelerates proliferation and inflammation and suppresses apoptosis of endometrial stromal cells via the microRNA-142-3p/CXCR7 axis.

MALAT1, microRNA (miR)-142-3p, and CXCR7 are critical molecules mediating endometriosis progression, and their correlation in endometriosis has been barely discussed. Thus, this research sought to survey the impact of MALAT1 on endometrial stromal cell (ESC) proliferation, apoptosis, and inflammation via miR-142-3p/CXCR7 axis to promote explorations on endometriosis. In endometrial tissues and ESCs, CXCR7 expression was determined by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and western blot analysis and miR-142-3p and MALAT1 expression by qRT-PCR.

Reconfigurable Antenna Array Direction Finding System Based on a Fast Search Algorithm.

In a traditional antenna array direction finding system, all the antenna sensors need to work or shut down at the same time, which often leads to signal crosstalk, signal distortion, and other electromagnetic compatibility problems. In addition, the direction-finding algorithm in a traditional system needs a tremendous spectral search, which consumes considerable time. To compensate for these deficiencies, a reconfigurable antenna array direction finding system is established in this paper.

Profiling of somatic mutations and fusion genes in acute myeloid leukemia patients with FLT3-ITD or FLT3-TKD mutation at diagnosis reveals distinct evolutionary patterns.

Background: The receptor tyrosine kinase FLT3 with internal tandem duplications within the juxtamembrane domain (FLT3-ITD) is a poor prognostic factor; however, the prognostic significance of missense mutation in the tyrosine kinase domain (FLT3-TKD) is controversial. Furthermore, the accompanying mutations and fusion genes with FLT3 mutations are unclear in acute myeloid leukemia (AML).

Methods: We investigated FLT3 mutations and their correlation with other gene mutations and gene fusions through two RNA-seq based next-generation sequencing (NGS) method and prognostic impact in 207 de novo AML patients.

Self-cut titanium-coated polypropylene mesh versus pre-cut mesh-kit for transvaginal treatment of severe pelvic organ prolapse: study protocol for a multicenter non-inferiority trial.

Background: Pelvic organ prolapse (POP) is a common health problem and has significant negative effects on a woman's quality of life. The transvaginal mesh procedure is a durable reconstructive surgery, but the mesh kits are expensive for underdeveloped countries. Our previous case-series study showed that the use of self-cut mesh had a good success rate (91.