An evaluation of factors affecting clinical outcomes in penetrating cardiac injuries: A single center experience.

Background: Penetrating cardiac injury (PCI) has highly mortal outcome. Therefore, management of this emergency situation is extremely important. The present study is an investigation of main factors that can affect mortality and morbidity in PCI.

Evaluation of Pericardial Fluid C-Type Natriuretic Peptide Levels in Patients Undergoing Coronary Bypass Surgery.

 Neurohumoral and hemodynamic mechanisms have an effect on cardiac activity. C-type natriuretic peptide (CNP) is accessible in the cardiovascular system. The aim of this study was to determine whether CNP concentrations in pericardial fluid and blood are related to cardiac dysfunction in patients undergoing coronary artery bypass graft surgery.

Simple blood tests as predictive markers of disease severity and clinical condition in patients with venous insufficiency.

Chronic venous insufficiency (CVI) is a progressive inflammatory disease. Because of its inflammatory nature, several circulating markers were investigated for predicting disease progression. We aimed to investigate simple inflammatory blood markers as predictors of clinical class and disease severity in patients with CVI.

Pharmacomechanical thrombolysis with a rotator thrombolysis device in iliofemoral deep venous thrombosis.

Objective: Deep venous thrombosis (DVT) is a life-threatening and morbid pathology. This study aimed to investigate the efficacy of an early thrombolysis procedure using a rotator thrombolysis device.

Methods: Sixty-seven patients with acute proximal DVT were enrolled in the study.

Evaluation of the vasoplegic impact of papaverine in the rat aorta.

Objective: To identify the degree of vasoplegic affinity of papaverine to rat thoracic aortas following constriction caused by adrenalin, serotonin and potassium chloride in an in-vitro model.

Methods: The in vitro vasoplegic efficacy of papaverine against adrenalin (10(-5) M), serotonin (5HT) (10(-4) M), and KCI (60 mM) was assessed, using a rat aortic vasospasm model in an organ bath. First, aortic rings were constricted with a submaximal dose of vasoconstrictor agents.

Values of troponin T and myoglobin predictive of non-cardiac ischemia in rats.

Objectives: Biochemical markers are important for the timely diagnosis and follow-up of ischemic events. Most of the markers have been previously studied in the context of cardiac ischemia. However, research on markers of non-cardiac events has been insufficient.

The relationship between complete blood count parameters and Fontaine's Stages in patients with peripheral arterial disease.

Objective: The aim of the present study is to evaluate whether blood count parameters differ according to the stages of Fontaine's classification and to investigate the relationship between hemogram parameters and the severity of the disease.

Method: Eighty-two peripheral arterial disease patients were examined prospectively. Patients were classified according to the Fontaine classification system.

Investigation of the antiangiogenic behaviors of rivaroxaban and low molecular weight heparins.

Antithrombotic agents play important roles in the prophylactic and therapeutic management of many cardiovascular disorders. Therefore, many researchers have focused on developing new strategies for anticoagulation. New oral anticoagulants and factor Xa inhibitors are products of such research.

Factor-Xa inhibitors protect against systemic oxidant damage induced by peripheral-ischemia reperfusion.

Factor-Xa inhibitors are often used for prophylaxis and for the treatment of thrombotic vascular disorders. However, it is not known whether they are beneficial during the recanalization of the thrombotic vascular segment and during tissue reperfusion. Herein, we describe an animal study that was designed to investigate the possible protective effects and antioxidant properties of factor-Xa inhibitors.

Can calcium dobesilate be used safely for peripheral microvasculopathies that require neoangiogenesis?

Background: Calcium dobesilate (CaD) is a member of the synthetic veno-active drug family. Only a small number of reports are available that describe the micro-angiogenic effects of CaD in the current literature.

Material And Methods: The antiangiogenic potential of CaD was compared with bevacizumab (Bb), which is a potent angiogenesis inhibitor, in a chick chorioallantoic membrane model.

Rosuvastatin may have neuroprotective effect on spinal cord ischemia reperfusion injury.

Ischemia reperfusion injuries can be threatening to end organ viability and can progress, with mortal and morbid outcomes. In particular, neural tissues are highly sensitive to hypoxia and reperfusion stress. This study aimed to determine the neuroprotective effects of rosuvastatin on spinal cord ischemia reperfusion injury.

Reasons, procedures, and outcomes in ventriculoatrial shunts: A single-center experience.

Background: Ventricular shunts are used to drain cerebrospinal fluid into extra-cranial spaces. Ventriculoatrial (VA) shunts are provided to transfer cerebrospinal fluid from the cerebral ventricle into the right atrium of the heart. A single center experience of indications, procedure, and clinical outcomes in VA shunt was presented in current study.

Serum nitric oxide level could be a predictive biomarker for detection of critical ischaemia duration.

Objective: To investigate the predictive value of serum nitrate (nitrogen oxide: NOx) levels in the detection of peripheral and mesenteric ischaemia durations.

Methods: Rats were sacrificed for determining the basal serum values of NOx in Group I without any intervention. The superior mesenteric artery was clamped in Groups II and III and blood samples were taken at 120 minutes in Group II and at 360 minutes in Group III.

An alternative therapy for recurrent stasis ulcers in chronic venous insufficiency: venocuff.

Chronic venous insufficiency may cause stasis ulcers that significantly impact on the quality of life. Many methods have been described for preventing or treating these ulcers. However, stasis ulcers often recur as a result of continuing venous insufficiency.

Aortic coarctation in the presence of capillary hemangioma.

We report posterior mediastinal hemangioma in a 14-year-old girl patient with an extensive hemangioma encompassing the thoracic aorta, associated with complex coarctation. The masses were identified by contrast-enhanced computed tomography. An extra-anatomical bypass was made by grafting from the ascending to the distal descending aorta.

[Reexploration for bleeding and tamponade in intensive care unit following open heart surgery].

Objective: Following open-heart surgery some patients can need reexploration in the intensive care unit due to bleeding or pericardial tamponade. This study evaluates the impact of reexploration in the intensive care unit (ICU) on morbidity and mortality rates.

Methods: Between January 1990 and January 2002 overall 18,578 open heart surgery procedures were performed in our clinic and among them 570 (3%) patients required reexploration due to bleeding or pericardial tamponade.