Publications by authors named "Bina Ramamurthy"
Article Synopsis
- Auditory nerve fibers carry sound information through precise timing of action potentials (APs), with bushy cells (BCs) and T-stellate cells (SCs) demonstrating different AP properties and roles in sound processing.
- BCs have lower sodium conductance, resulting in nonovershooting APs that enhance temporal coding, while SCs, with normal overshooting APs, focus on encoding sound amplitude rather than timing.
- Research showed that increasing sodium conductance in BCs negatively affected their ability to detect timing accurately, suggesting that lower sodium channel availability is crucial for precise sound processing in auditory neurons.
J Neurophysiol
April 2015
Article Synopsis
- The dynamic-clamp technique allows researchers to simulate synaptic or voltage-gated conductances but is underused due to costly and complex setups that can be challenging for beginners.
- A new user-friendly interface has been created using common PC platforms, integrating National Instruments data acquisition with WaveMetrics IGOR for easier implementation.
- This dynamic clamp can mimic various conductances and operates at impressive speeds over 100 kHz, ensuring quick responses with minimal delays.
