Publications by authors named "BinSheng He"

The Spodoptera litura, a crucial polyphagous pest, has emerged as a major threat to the agricultural sector. Regrettably, despite ongoing efforts, scientists have yet to uncover a safe and efficient control medication to tackle this pressing issue. Toosendanin (TSN), a commercial insecticidal active ingredient used to manage various pests in the field, has adverse effects on Spodoptera litura.

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To study the clinical features of nivolumab-induced immune-related pancreatitis and to provide evidence for its recognition and treatment. Cases of nivolumab-induced pancreatitis were collected by searching Chinese and English databases until November 30, 2024. Forty-three patients were included, with a median age of 61 years (range 23, 79).

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The major facilitator superfamily domain containing 8 (MFSD8) belongs to an orphan transporter protein expressed in a wide range of tissues. Nevertheless, the specific role of MFSD8 in human health and disease remains unknown. This study aimed to evaluate the role of MFSD8 protein on metabolic function using untargeted metabolomics analysis in human umbilical vein endothelial cells (HUVECs).

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Reducing the negative impact of oxidative stress (OS) on weaned piglets is crucial for the further development of the pig industry. Our previous studies found that Lactobacillus delbrueckii (LAB) can alleviate OS and protect intestinal health by activating TLR2 and TLR4 expressions in weaned piglets. This research aimed to verify whether LAB can alleviate OS and intestinal barrier injuries in IPEC-J2 cells by activating TLR2 and TLR4.

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Background: Nivolumab has been linked to occurrences of uveitis, yet the clinical features associated with these episodes remain unclear. This study aimed to explore the clinical characteristics of uveitis induced by nivolumab and to offer guidance for its prevention, diagnosis, and treatment.

Methods: We conducted a retrospective analysis by gathering case reports related to nivolumab-induced uveitis from both Chinese and English databases, covering the period from inception until 30 September 2024.

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Cardiometabolic diseases (CMD) are leading causes of death and disability worldwide, with complex pathophysiological mechanisms in which inflammation plays a crucial role. This review aims to elucidate the molecular and cellular mechanisms within the inflammatory microenvironment of atherosclerosis, hypertension and diabetic cardiomyopathy. In atherosclerosis, oxidized low-density lipoprotein (ox-LDL) and pro-inflammatory cytokines such as Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-α) activate immune cells contributing to foam cell formation and arterial wall thickening.

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The understanding of pembrolizumab-induced Stevens-Johnson syndrome (SJS) /toxic epidermal necrolysis (TEN) primarily derives from case reports, leaving specific clinical features largely unknown. This study aims to investigate the clinical characteristics associated with pembrolizumab-induced SJS/TEN and to encourage the judicious use of pembrolizumab. Retrieve reports on pembrolizumab induced SJS/TEN before September 30, 2024 for retrospective analysis.

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, a perennial herb belonging to the Zingiberaceae family, has a long history of traditional medicinal use. The present study evaluated the efficacy of different concentrations of essential oil (AEO) on the growth performance, serum antioxidation capacities, immune function, apparent digestibility of nutrients, and gut microbiota in fattening pigs. A total of 120 pigs were divided into five treatments, with six replicates each and four pigs per replicate.

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Objective: To investigate the value of combined detection of T-cell immunoglobulin mucin molecule 3 (sTim-3), pepsinogen (PG) and programmed death receptor 1 (PD-L1) in evaluating treatment efficacy and predicting the prognosis of immunosuppressant therapy in advanced gastric cancer.

Methods: A retrospective study was conducted on the data of 90 patients with advanced gastric cancer who were treated at the First Affiliated Hospital of Changsha Medical University from January 2019 to February 2021. Patients were divided into effective and ineffective groups based on treatment response.

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Background: Alzheimer's disease (AD) is a degenerative brain disease without a cure. (LJF), a traditional Chinese herbal medicine, possesses a neuroprotective effect, but its mechanisms for AD are not well understood. This study aimed to investigate potential targets and constituents of LJF against AD.

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Article Synopsis
  • Researchers optimized the hydrothermal pretreatment of waste tissue paper for increased ethanol yield using a high-pressure reactor at 160 °C with pure water for 50 minutes.
  • The pretreated tissue paper showed a significant increase in cellulose content (81.19%) and higher reducing sugar yield (0.61 g/g paper) compared to untreated paper.
  • Two fermentation methods were compared: a mixed strain of Saccharomyces cerevisiae produced 28.11 g/L of ethanol, while a single strain produced more (35.15 g/L) in the same time frame.
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  • * Histone deacetylases (HDACs) are important epigenetic regulators linked to gene expression and have gained attention in drug development due to abnormal HDAC activity being associated with epilepsy.
  • * This review highlights the roles of different HDAC subunits in epilepsy, discusses their regulatory mechanisms, and considers the potential of targeting HDACs for new therapeutic strategies to improve epilepsy treatment.
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While there is ample evidence indicating an increased occurrence of general neurological conditions among individuals with diabetes, there has been limited exploration into the cause-and-effect connection between type 2 diabetes (T2D) and specific neurological disorders, including conditions like carpal tunnel syndrome and Bell's palsy. We used Mendelian randomization (MR) approach to investigate the causal effects of T2D on 67 neurological diseases. We primarily utilized the inverse-variance weighted method for the analysis, and also employed the weighted median and MR-Egger methods in our study.

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PD-1/PD-L1 inhibitors have increasingly been associated with the occurrence of subacute cutaneous lupus erythematosus (SCLE), but the clinical characteristics and outcomes remain under-explored. Literature on PD-1/PD-L1 inhibitors induced SCLE was retrieved from Chinese and English databases until June 31, 2024, and clinical data of patients were extracted for retrospective analysis. Twenty-nine patients participated, with a median age of 63 years (range 43, 80).

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  • Sweet syndrome (SS) is a rare skin reaction linked to granulocyte colony-stimulating factor (G-CSF), and this study investigates its characteristics to aid in prevention and management.
  • The analysis of 50 cases showed that SS typically appears 7 days after G-CSF treatment, with common symptoms including fever and various skin lesions like papules and nodules.
  • Effective management involves stopping G-CSF and using corticosteroids, leading to improvement in symptoms; however, re-administering G-CSF is discouraged to prevent recurrence of SS.
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  • Non-coding RNAs (ncRNAs) are RNA molecules that do not code for proteins but play crucial roles in regulating gene expression and cellular functions, particularly in processes like cell growth and programmed cell death (apoptosis).
  • The ferroptosis signaling pathway, which is a recently identified form of cell death, influences various biological processes and is controlled by a network of interconnected pathways.
  • Research indicates that ncRNAs can regulate important genes within the ferroptosis pathway, offering insights that could lead to new treatment approaches for preeclampsia by targeting the interactions between ncRNAs and ferroptosis.
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Background: Patients undergoing non-major orthopedic surgery often face an increased risk of venous thromboembolism due to the necessity of immobilization postoperatively. Current guidelines commonly recommend the use of low-molecular-weight heparin (LMWH) for prophylaxis, but it is associated with low patient compliance and certain side effects. We conducted a meta-analysis of randomized controlled trials (RCTs) to assess the effectiveness and safety of rivaroxaban or LMWH for thromboprophylaxis following non-major orthopedic surgery.

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Background: Evidence suggests a connection between DNA methylation (DNAm) aging and reproductive aging. However, the causal relationship between DNAm and age at menopause remains uncertain.

Methods: Employing established DNAm epigenetic clocks, such as DNAm Hannum age acceleration (Hannum), Intrinsic epigenetic age acceleration (IEAA), DNAm-estimated granulocyte proportions (Gran), DNAm GrimAge acceleration (GrimAgeAccel), DNAm PhenoAge acceleration (PhenoAgeAccel), and DNAm-estimated plasminogen activator inhibitor-1 levels (DNAmPAIadjAge), a bidirectional Mendelian randomization (MR) study was carried out to explore the potential causality between DNAm and menopausal age.

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Diabetes and its complications significantly affect individuals' quality of life. The etiology of diabetes mellitus and its associated complications is complex and not yet fully understood. There is an increasing emphasis on investigating the effects of endocrine disruptors on diabetes, as these substances can impact cellular processes, energy production, and utilization, ultimately leading to disturbances in energy homeostasis.

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Background: LINC-PINT was downregulated in nasopharyngeal carcinoma (NPC) and correlated with treatment efficiency of NPC. However, the underlying mechanism of LINC-PINT in NPC has not yet been fully explored.

Method: We used CellTiter luminescent assay, clone formation assay, Hoechst staining, and SYTO-9/PI staining to examine cell viability and cell apoptosis regulated by LINC-PINT in NPC cells.

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The flavonoid compound chinonin is one of the main active components of with multiple activities, including anti-inflammatory and antioxidant properties, protection of mitochondrial function and regulation of immunity. In this paper, we reviewed recent research progress on the protective effect of chinonin on brain injury in neurological diseases. "Chinonin" OR "Mangiferin" AND "Nervous system diseases" OR "Neuroprotection" was used as the terms for search in PumMed.

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Article Synopsis
  • Allicin (AL), a compound derived from garlic, shows significant anti-cancer effects against various types, though its impact on human nasopharyngeal carcinoma was previously unexplored.
  • This study discovered that AL inhibits cell proliferation, migration, invasion, and survival in nasopharyngeal carcinoma cells by inducing ferroptosis, a regulated form of cell death linked to iron.
  • The mechanism involves reducing levels of GSH and GPX4, while increasing toxic lipid peroxides (LPO) and reactive oxygen species (ROS), suggesting AL's potential as a therapeutic agent for this type of cancer.
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Maintaining a balanced bile acids (BAs) metabolism is essential for lipid and cholesterol metabolism, as well as fat intake and absorption. The development of obesity may be intricately linked to BAs and their conjugated compounds. Our study aims to assess how BAs influence the obesity indicators by Mendelian randomization (MR) analysis.

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  • Metabolic abnormalities are connected to ovarian cancer (OC), but the link between body measurements and OC risk remains inconsistent.
  • The study utilized a Mendelian randomization approach, analyzing data from genome-wide association studies to explore causal relationships between metabolic factors and OC risk, employing various statistical methods for accuracy.
  • Results indicated that 10 metabolic factors, including basal metabolic rate and body fat percentage, are causally associated with an increased risk of OC, highlighting the impact of fat accumulation and distribution on cancer risk.
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Introduction: Mangiferin is a Chinese herbal extract with multiple biological activities. Mangiferin can penetrate the blood‒brain barrier and has potential in the treatment of nervous system diseases. These findings suggest that mangiferin protects the neurological function in ischemic stroke rats by targeting multiple signaling pathways.

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