GRIK3 deficiency promotes non-small cell lung cancer progression by the regulation of the UBE2C/CDK1/Wnt signaling pathway.

Glutamate ionotropic receptor kainate type subunit 3 (GRIK3) is a predominant excitatory neurotransmitter receptor in the mammalian brain. While it is known that GRIK3 is involved in normal neurophysiologic processes, its biological functions in tumor progression are still poorly understood due to limited investigation. In this study, we reported for the first time that GRIK3 expression was downregulated in non-small cell lung cancer (NSCLC) tissues as compared to paracarcinoma tissues.

Comparative study of B content and δ B in the enamel of isolated teeth from brothers in the same family.

Rationale: The quantity of boron (B) and its isotopic ratios in tooth can provide information on dietary habits and oral health of individuals. These metrics are gradually being used in stomatology, environmental science and geochemistry.

Methods: This study measured the B concentration and δ B in the enamel of isolated teeth from brothers in the same family living in high-B-exposure areas at different times using inductively coupled plasma mass spectrometry (ICP-MS) and multicollector ICP-MS.

[Diagnostic values of the clinical characteristics of chronic cough].

Objective: To evaluate whether the clinical characteristics of chronic cough were helpful in determining its specific causes.

Methods: Patients with chronic cough were evaluated by a validated systematic diagnostic protocol. The patients with identified single cause were divided into 4 groups accordingly: cough-variant asthma (CVA), upper airway cough syndrome (UACS) or post-nasal drip syndrome (PNDS), eosinophilic bronchitis (EB), gastroesophageal reflux related cough (GERC), and the characteristics of the timing, character, onset and associated manifestations of chronic cough in different causes were compared.