Publications by authors named "Bin-Hui Zhou"
CTGF regulated by ATF6 inhibits vascular endothelial inflammation and reduces hepatic ischemia-reperfusion injury.
Biochim Biophys Acta Mol Basis Dis
December 2024
Article Synopsis
- Vascular endothelial inflammation plays a key role in hepatic ischemia-reperfusion injury (IRI), and connective tissue growth factor (CTGF) secreted by endothelial cells is protective against liver damage but its regulatory mechanisms are unclear.
- The study investigates how ATF6, activated by endoplasmic reticulum stress, regulates CTGF to mitigate inflammation and liver damage during IRI, finding that ATF6 enhances CTGF expression while inhibiting inflammatory responses.
- Clinical evidence shows a rise in CTGF post-IRI, which inversely correlates with inflammatory cytokines, suggesting that targeting the ATF6-CTGF pathway could be a new strategy for diagnosing and treating liver IRI.
The growth of microbe and formation of biofilm in water distribution system were important factors affecting the security of water quality. The number of ammonia-oxidizing bacteria (AOB) in biofilm of a chloraminated drinking water distribution system in Shanghai was detected by MPN-Griess method, and the relations among AOB, nitrification and chloraminated disinfection were analyzed. Meanwhile, the effects of AOB on chloraminated disinfection fastness and attenuation by simulation experiment were studied.
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