Efficacy of EGFR-TKI sequential therapy in patients with exon 19 insertion-positive non-small-cell lung cancer: A case report.

Background: Insertions in exon 19 in the epidermal growth factor receptor gene (EGFR) is a rarely seen mutation in non-small cell lung cancer. These patients have been effectively treated with sequential EGFR tyrosine kinase inhibitors (TKIs).

Case Summary: Here, we presented a case of non-small cell lung cancer, stage IIIB, with exon 19 insertion mutation as detected in the right lower lobe by next-generation sequencing.

Heavy metal concentrations and associated health risks in edible tissues of marine nekton from the outer Pearl River Estuary, South China Sea.

Seven heavy metals including Hg, Cu, Pb, Cd, Zn, Cr, and As were examined in seventeen marine nekton species from the outer Pearl River Estuary (PRE), South China Sea. On the wet weight basis, the metal concentration ranges were 0.016-0.

The complete mitochondrial genome of milk shark, (Ruppell 1837).

The complete mitogenome sequence of the milk shark, of which was determined using long PCR. The genome was 16,693 bp in length and it contained 13 protein-coding genes, 2 ribosomal RNA genes, 22 transfer RNA genes, and 1 D-loop region. The overall base composition of the heavy strand is A (31.