A novel super-enhancer-related risk model for predicting prognosis and guiding personalized treatment in hepatocellular carcinoma.

Background: Our research endeavored to develop a robust predictive signature grounded in super-enhancer-related genes (SERGs), with the dual objectives of forecasting survival outcomes and evaluating the tumor immune microenvironment (TiME) in hepatocellular carcinoma (HCC).

Methods: HCC RNA-sequencing data were retrieved from The Cancer Genome Atlas (TCGA), and 365 patients were randomly assigned to training or testing sets in 1:1 ratio. SERGs of HCC were downloaded from Super-Enhancer Database (SEdb).

Total Flavonoids of Chuju Decrease Oxidative Stress and Cell Apoptosis in Ischemic Stroke Rats: Network and Experimental Analyses.

Pharmacological research results showed that total flavonoids of Chuju (TFCJ) could be used to treat acute myocardial ischemia and myocardial ischemia-reperfusion injury. In this study, we explored the protective effect of TFCJ on ischemic stroke (IS) in the IS rat model. We hypothesized that TFCJ might exert its neuroprotective effects by suppressing apoptosis and oxidative stress that are closely related to PI3K/Akt/mTOR signaling pathway.

A Network Pharmacology Approach for Exploring the Mechanisms of Saponins in Ischaemic Stroke.

Background: saponins (PNS) have been deemed effective herb compounds for treating ischaemic stroke (IS) and improving the quality of life of IS patients. This study aimed to investigate the underlying mechanisms of PNS in the treatment of IS based on network pharmacology.

Methods: PNS were identified from the Traditional Chinese Medicine System Pharmacology (TCMSP) database, and their possible targets were predicted using the PharmMapper database.

Magnetization jump in one dimensional J - Q model with anisotropic exchange.

We investigate the adiabatic magnetization process of the one-dimensional J - Q model with XXZ anisotropy g in an external magnetic field h by using density matrix renormalization group (DMRG) method. According to the characteristic of the magnetization curves, we draw a magnetization phase diagram consisting of four phases. For a fixed nonzero pair coupling Q, (i) when g < -1, the ground state is always ferromagnetic in spite of h; (ii) when g > -1 but still small, the whole magnetization curve is continuous and smooth; (iii) if further increasing g, there is a macroscopic magnetization jump from partially- to fully-polarized state; (iv) for a sufficiently large g, the magnetization jump is from non- to fully-polarized state.

[Comparative Study on the Four Kinds of Flavonoids from Four Different Varieties of Dendranthema morifolium].

Objective: To establish a high phase liquid chromatography method of the content in quercetin,luteolin,apigenin,acacetin,and to compare the difference of content from four different varieties of Dendranthema morifolium in simultaneously.

Methods: The UPLC methods were adopted,and the chromatographic column was Waters ACQUITYUPLC; the column was BEH C18（ 50 mm ×2. 1 mm,1.

[Research on the changes of name of Wuzhuyu (Medicinal Evodia Fruit)].

The name of Wuzhuyu (Medicinal Evodia Fruit) comes from the place of "Wu", and the shape of its fruit, which is like a 'Zhuyu'. In addition, it is also called "Yi, Sha, Jiao, Dang, Yuejiao and Qiu" for different reasons; for example, "Yi" because of its processing and sacrificial function; and "Sha" because of the bug-killing function of its root and cortex. In Xin Xiu Ben Cao (Newly Revised Materia Medica) of the Tang Dynasty, its names were unified as Wuzhuyu.