Publications by authors named "Bin Yang He"
Background: The M1/M2 polarization of intestinal macrophages exerts an essential function in the pathogenesis of ulcerative colitis (UC), which can be adjusted to alleviate the UC symptoms.
Purpose: A kind of pH-sensitive lipid calcium phosphate core-shell nanoparticles (NPs), co-loading with dexamethasone (Dex) and its water-soluble salts, dexamethasone sodium phosphate (Dsp), was constructed to comprehensively regulate macrophages in different states towards the M2 phenotype to promote anti-inflammatory effects.
Methods: Dex and Dsp were loaded in the outer lipid shell and inner lipid calcium phosphate (Cap) core of the LCaP NPs, respectively.
Article Synopsis
- Long-term use of glucocorticoids (GCs) for treating ulcerative colitis (UC) can cause severe side effects; local administration via enema could concentrate GCs at the inflamed site but faces challenges due to short colonic residence time caused by diarrhea.
- To improve treatment efficacy, researchers developed mucoadhesive nanoparticles (NPs) that can attach to inflamed colonic tissue, enhancing the local concentration of dexamethasone derivatives (DDs) for better targeted therapy.
- In vivo tests on colitis mice showed that the synthesized nanoparticles had good stability, sustained release, and effectively improved UC symptoms, indicating potential benefits for patients.