CD90's role in vascularization and healing of rib fractures: insights from Dll4/notch regulation.

Background: Vascularization after rib fracture is a crucial physiological process that is essential for the repair and healing of the rib. Studies have shown that CD90 plays a critical role in regulating rib fracture healing, but the underlying mechanism of its role has not been fully elucidated.

Methods: CD90 adenovirus knockout mice were used to construct a rib injury model.

Raman spectroscopy for esophageal tumor diagnosis and delineation using machine learning and the portable Raman spectrometer.

Esophageal cancer is one of the leading causes of cancer-related deaths worldwide. The identification of residual tumor tissues in the surgical margin of esophageal cancer is essential for the treatment and prognosis of cancer patients. But the current diagnostic methods, either pathological frozen section or paraffin section examination, are laborious, time-consuming, and inconvenient.

Clinical features of idiopathic epiretinal membrane in children and the factors influencing postoperative visual acuity.

Purpose: To describe the characteristics and surgical outcomes of idiopathic epiretinal membrane (iERM) in children and to determine the factors associated with postoperative visual acuity (VA).

Methods: We retrospectively reviewed the medical records of 17 patients with iERM (age, < 18 years) who had undergone ERM surgery from 2009 to 2021. Spectral-domain optical coherence tomography features were documented.

Predictive effect of TCED-HFV grading and imaging biomarkers on anti-VEGF therapy in diabetic macular edema.

Background: To evaluate the predictive effect of TCED-HFV grading and imaging biomarkers on anti-vascular endothelial growth factor (anti-VEGF) treatment in diabetic macular edema (DME).

Methods: 81 eyes of 81 DME patients who were treated with anti-VEGF were included in this retrospective cohort study. All patients underwent a comprehensive ophthalmic examination at baseline and follow-up, including best-corrected visual acuity (BCVA), fundus photography, and spectral domain-optical coherence tomography (SD-OCT).

Evaluation of the Hand Motion and Peeling Force in Inner Limiting Membrane Peeling.

Purpose: Robot assistance in membrane peeling may improve precision and dexterity or prevent complications by task automation. To design robotic devices, surgical instruments' velocity, acceptable position/pose error, and load ability need to be precisely quantified.

Methods: A fiber Bragg grating and inertial sensors are attached to forceps.

Identification of NLE1/CDK1 axis as key regulator in the development and progression of non-small cell lung cancer.

Non-small cell lung cancer (NSCLC) is the most common pathological type of lung cancer, which is a severer threaten to human health because of its extremely high morbidity and mortality. In this study, the role of Notchless homolog 1 (NLE1) in the development of NSCLC was investigated and the underlying mechanism was explored. The outcomes showed that NLE1 expression is significantly higher in tumor tissues than normal tissues, and is correlated with the pathological stage.

EFFECTS OF ECTOPIC INNER FOVEAL LAYERS ON FOVEAL CONFIGURATION AND VISUAL FUNCTION AFTER IDIOPATHIC EPIRETINAL MEMBRANE SURGERY.

Purpose: To investigate the effects of ectopic inner foveal layers (EIFLs) on foveal configuration recovery and visual acuity after idiopathic epiretinal membrane removal and analyze the relationship of foveal configuration recovery between 1-month and long-term postoperatively.

Methods: This retrospective study included 216 consecutive eyes with idiopathic epiretinal membrane that underwent vitrectomy surgery. A comprehensive ophthalmic examination was performed for all patients before and 1, 4, 10, and 24 months after surgery.

Automated detection of severe diabetic retinopathy using deep learning method.

Purpose: The purpose of this study is to develop and validate the intelligent diagnosis of severe DR with lesion recognition based on color fundus photography.

Methods: The Kaggle public dataset for DR grading is used in the project, including 53,576 fundus photos in the test set, 28,101 in the training set, and 7,025 in the validation set. We randomly select 4,192 images for lesion annotation.

The dynamics of carbon on green energy equity investment: quantile-on-quantile and quantile coherency approaches.

We analyze the dynamic correlation between the carbon price and the stock returns of green energy companies and calculate the hedging effect of the carbon price on stock returns in green energy sectors. The results show that the coefficients of the carbon price change with time and are vulnerable to extreme events like the COVID-19. The quantile-on-quantile (QQ) model results reveal a dynamic effect from the carbon price to the stock returns of green energy sectors.

Suprachoroidal hemorrhage associated with pars plana vitrectomy.

Purpose: To analyze the characteristics, related risk factors, and prognosis of suprachoroidal hemorrhage (SCH) associated with pars plana vitrectomy (PPV).

Methods: Cases of SCH associated with PPV excluding trauma were retrospectively analyzed in Beijing Tongren Hospital between January 2010 and June 2020. The data collected included general data, myopia status, axial length, state of the crystalline lens, SCH onset time, range, treatment method, visual prognosis, and methods of operation and anesthesia.

Does Environmental Policy Affect Green Total Factor Productivity? Quasi-Natural Experiment Based on China's Air Pollution Control and Prevention Action Plan.

It is the scientific way to promote the transformation and optimization of an industrial structure to promote the improvement of its green total factor productivity () by formulating environmental regulation policies. Based on the panel data of 30 provinces in China from 2004 to 2017, this paper takes the "Air Pollution Control and Prevention Action Plan" (APCP Action Plan) as the proxy dummy variable of environmental regulation, and uses the difference-in-differences (DID) model to explore the impact of the implementation of the APCP Action Plan on . In addition, by constructing the industrial structure optimization index, this paper analyzes how the APCP Action Plan policy affects through the transformation and optimization of industrial structure.

Deep learning-based detection and stage grading for optimising diagnosis of diabetic retinopathy.

Aims: To establish an automated method for identifying referable diabetic retinopathy (DR), defined as moderate nonproliferative DR and above, using deep learning-based lesion detection and stage grading.

Materials And Methods: A set of 12,252 eligible fundus images of diabetic patients were manually annotated by 45 licenced ophthalmologists and were randomly split into training, validation, and internal test sets (ratio of 7:1:2). Another set of 565 eligible consecutive clinical fundus images was established as an external test set.

Comparison between liraglutide alone and liraglutide in combination with insulin on osteoporotic rats and their effect on bone mineral density.

Objectives: To compare the therapeutic efficacy of liraglutide (LRG) single drug combined with insulin (Ins) on osteoporosis in rats and its effect on bone mineral density (BMD). A rat model of diabetes combined with osteoporosis was established.

Methods: 40 Sprague-Dawley rats were divided into four groups (blank, control, LRG and LRG+Ins).

Novel use of an adjustable single 8-0 polypropylene suture of scleral fixation without conjunctival dissection.

Background: This report serves to describe the use of a novel adjustable single 8-0 polypropylene suture for scleral fixation without conjunctival dissection, and to describe related clinical outcomes associated with this approach.

Methods: In this study, we retrospectively reviewed 28 eyes from 27 patients that underwent scleral fixation of the intraocular lens (IOL) without conjunctival dissection using an adjustable single 8-0 polypropylene suture at the Beijing Tongren Eye Center between April 2018 and April 2019. For this surgical approach, a 23-gauge infusion cannula was set, after which two Hoffmann scleral pockets were created.

Spillover and quantile linkage between oil price shocks and stock returns: new evidence from G7 countries.

The link between crude oil price and stock returns of the Group of Seven (G7) countries (Canada, France, Germany, Italy, Japan, the United Kingdom, and the United States) was analyzed in this study using monthly data from January 1999 to March 2020. We adopt a similar approach to Kilian (Am Econ Rev 99(3):1053-1069, 2009) and construct a structural vector autoregression framework to decompose crude oil price shocks into oil supply shock, oil aggregate demand shock, and oil-specific demand shock. We then explore the distinct effects of different kinds of oil price shocks from various sources.

Impact of Buffer Layer Process and Na on Shunt Paths of Monolithic Series-connected CIGSSe Thin Film Solar Cells.

The illuminated current-voltage characteristics of Cu(In,Ga)(S,Se) (CIGSSe) thin film solar cells fabricated using two different buffer layer processes: chemical bath deposition (CBD) and atomic layer deposition (ALD) were investigated. The CIGSSe solar cell with the ALD buffer showed comparable conversion efficiency to the CIGSSe solar cell with CBD buffer but lower shunt resistance even though it showed lower point shunt defect density as measured in electroluminescence. The shunt paths were investigated in detail by capturing the high-resolution dark lock-in thermography images, resolving the shunt resistance contributions of the scribing patterns (P1, P3), and depth profiling of the constituent elements.

Pathophysiological correlations between fundus fluorescein angiography and optical coherence tomography results in patients with idiopathic epiretinal membranes.

The aim of the current study was to determine the association between fundus fluorescein angiography (FFA) image results, optical coherence tomography (OCT) imaging results and visual functions in patients with idiopathic epiretinal membranes (ERMs). A total of 80 eyes from 40 patients diagnosed with ERM were analyzed. Best-corrected visual acuity (BCVA) and metamorphopsia were measured using the Early Treatment Diabetic Retinopathy Study eye chart and M-charts, respectively.

Evaluation of hyperreflective foci as a prognostic factor of visual outcome in retinal vein occlusion.

Aim: To evaluate the potential role of hyperreflective foci (HF) as a prognostic indicator of visual outcome in patients with macular edema (ME) due to retinal vein occlusion (RVO).

Methods: We retrospectively reviewed 50 eyes of 50 patients with ME due to ischemic central retinal vein occlusion (CRVO), non-ischemic CRVO and branch retinal vein occlusion (BRVO) who were treated with anti-vascular endothelial growth factor (anti-VEGF) at Beijing Tongren Eye Center from January 2013 to July 2016. All patients underwent best-corrected visual acuity (BCVA), spectral domain optical coherence tomography (SD-OCT) at baseline and follow-up.

Inhibition of choroidal neovascularization by lentivirus-mediated PEDF gene transfer in rats.

Aim: To evaluate the effects of lentivirus-mediated pigment epithelium-derived factor (PEDF) gene transfer performed in treatment of rats with established choroidal neovascularization (CNV), and investigates the mechanism by which PEDF inhibits CNV in rats.

Methods: Brown Norway (BN) rats (n=204) were induced by exposure to a laser, and then randomly assigned to 3 groups: no treatment; treatments with intravitreal injection of lentivirus-PEDF-green fluorescent protein (GFP) or lentivirus-control GFP (free fluorescent protein). Following induction and treatment, the CNV tissue was assessed for form, size and vessel leakage by fluorescein fundus angiography (FFA), optical coherence tomography (OCT), histopathology, and examination of choroidal flat mounts.

Risk factors for choroidal detachment following rhegmatogenous retinal detachment in a chinese population.

Backgroud: Choroidal detachment (CD) following primary rhegmatogenous retinal detachment (RRD) is a special type of RRD. The purpose of this study is to investigate the potential risk factors of RRD with CD in a Chinese population.

Methods: All of 201 consecutive RRD with CD patients and 210 RRD without CD patients were enrolled in this case-control retrospective study.

Neuroprotective effect of curcumin against oxidative damage in BV-2 microglia and high intraocular pressure animal model.

Purpose: The involvement of local and systemic oxidative stress in intraocular pressure (IOP) elevation and optic nerve damage has been hypothesized in the pathogenesis of glaucoma. In this study, we aim to evaluate the antioxidant effects of curcumin in BV-2 microglia oxidative damage and assess its neuroprotective effects in a chronic high IOP rat model.

Methods: BV-2 microglia cell line was used in an in vitro study and Wistar rats were used in an in vivo study.

An improved experimental method for simulating erosion processes by concentrated channel flow.

Rill erosion is an important process that occurs on hill slopes, including sloped farmland. Laboratory simulations have been vital to understanding rill erosion. Previous experiments obtained sediment yields using rills of various lengths to get the sedimentation process, which disrupted the continuity of the rill erosion process and was time-consuming.

Comparative study of laser-induced choroidal neovascularization in rats by paraffin sections, frozen sections and high-resolution optical coherence tomography.

Purpose: The purpose of this study was to demonstrate the value of a quantitative study concerning experimental choroidal neovascularization (CNV) tissue by correlating the paraffin sections and frozen sections with optical coherence tomography (OCT) images.

Methods: After OCT imaging was performed, four right eyes from the normal Brown Norway (BN) rats were made into paraffin sections and four left eyes were made into frozen sections. Laser photocoagulation was performed on the right eyes of the other 32 BN rats to induce CNV; these rats then were divided into two groups.

Non-buckled vitrectomy for retinal detachment with inferior breaks and proliferative vitreoretinophathy.

Aim: To investigate the efficacy of non-buckled vitrectomy with classical endotamponade agents in the treatment of primary retinal detachment (RD) complicated by inferior breaks and proliferative vitreoretinophathy (PVR).

Methods: A retrospective, consecutive and case series study of 40 patients with inferior break RD and PVR ≥C1 was conducted. All patients underwent a standard 3-port 20-gauge pars plana vitrectomy (PPV) with gas or silicone oil tamponade without supplementary scleral buckling.

[Influence of the fusion of bone graft in spine of rabbit treated with lower intensity ultrasound].

Objective: To observe the influence of the fusion of bone graft in spine of rabbits which were treated with lower intensity ultrasound.

Methods: Forty 12-month-old rabbits were made to be the models of bone graft in post-lateral between two homonymy processus transverses in lumbar, and divided into treatment group (B) and control group (A) randomly. Twenty rabbits of treatment group were treated with lower intensity ultrasound, killed after six weeks, and took radiological examination, measured indexs of biomechanics.