Adverse event profile of crizotinib in real-world from the FAERS database: a 12-year pharmacovigilance study.

Aim: Crizotinib, an anaplastic lymphoma kinase tyrosine kinase inhibitor (ALK-TKI). It gained approval from the U.S.

Fine particulate matter pollution in the Sichuan Basin of China from 2013 to 2020: Sources, emissions, and mortality burden.

Fine particulate matter (PM) pollution is a critical air quality concern which poses threats to public health. Despite strict air pollution control measures implemented in China since 2013, PM exceedances and region-wide PM episodes are still frequently observed in the Sichuan Basin (SCB) located in southwestern China. Here, we examine ambient PM pollution within the SCB from 2013 to 2020, focusing on emission sources, trends, and health outcomes.

Cognitive impairments in first-episode psychosis patients with attenuated niacin response.

Background: Psychosis is a complex brain disorder with diverse biological subtypes influenced by various pathogenic mechanisms, which can affect treatment efficacy. The ANR(Attenuated Niacin Response) subtype is characterized by pronounced negative symptoms and functional impairments, suggesting a distinct clinical profile. However, research on the cognitive characteristics associated with the ANR subtype in drug-naïve first-episode psychosis(FEP) patients remains limited.

Identifying neurobiological heterogeneity in clinical high-risk psychosis: a data-driven biotyping approach using resting-state functional connectivity.

To explore the neurobiological heterogeneity within the Clinical High-Risk (CHR) for psychosis population, this study aimed to identify and characterize distinct neurobiological biotypes within CHR using features from resting-state functional networks. A total of 239 participants from the Shanghai At Risk for Psychosis (SHARP) program were enrolled, consisting of 151 CHR individuals and 88 matched healthy controls (HCs). Functional connectivity (FC) features that were correlated with symptom severity were subjected to the single-cell interpretation through multikernel learning (SIMLR) algorithm in order to identify latent homogeneous subgroups.

MAGMA: Microbial and Algal Growth Modeling Application.

Kinetic modeling of biochemical reactions and bioreactor systems can enhance and quantify knowledge gained from cell culture experiments and has many applications in bioprocess design and optimization. The Microbial and Algal Growth Modeling Application (MAGMA) is a user-friendly MATLAB-based software for streamlining the development of kinetic models for various bioreactor systems. This study details the MAGMA workflow by demonstrating the creation of kinetic models with systems of ordinary differential equations (ODEs), model fitting by solving inverse problems, statistical evaluation of model fitting quality, and visual display of simulation results.

Total synthesis and antibacterial evaluation of lupalbigenin and isolupalbigenin.

Lupalbigenin () is an antibacterial isoflavone isolated from (Lour.) Corner (Moraceae). In this study, we achieved the first gram-scale synthesis of lupalbigenin () from commercially available genistein (), with a yield of 47.

The Optimal Radiotherapy Strategy for Patients With Small Cell Lung Cancer and Brain Metastasis: A Retrospective Analysis.

Background: Extensive-stage small cell lung cancer (ES-SCLC) is a notoriously aggressive malignancy frequently associated with brain metastases (BMs), presenting substantial therapeutic challenges. This study delves into the effectiveness of immunotherapy combined with diverse radiotherapy, especially the influence of brain radiotherapy (BRT) on survival outcomes in the immunotherapy era.

Methods: ES-SCLC patients treated at Xiangya Hospital and Xiangya Boai Hospital from February 2020 to June 2024 were retrospectively included.

Total Syntheses and Anti-Inflammatory Studies of Three Natural Coumarins: Glycycoumarin, Glycyrin, and 3--Methylglycyrol.

Licorice ( Fisch), a significant traditional Chinese herbal medicine, has been extensively utilized in China to treat various ailments. Natural bioactive coumarins, glycycoumarin, glycyrin, and 3--methylglycyrol, were isolated from licorice, and they exhibited various pharmacological properties. In this report, we have accomplished the total synthesis of glycycoumarin, glycyrin, and 3--methylglycyrol in 5-7 linear steps from commercially available 2,4,6-trihydroxybenzaldehyde with yields of 12.

Structural and functional abnormalities across clinical stages of psychosis: A multimodal neuroimaging investigation.

Background: Structural and functional neurobiological abnormalities have been observed in schizophrenia. Previous studies have concentrated on specific illness stages, obscuring relationships between functional/structural changes and disorder progression. The present study aimed to quantify structural and functional abnormalities across different clinical stages using functional near-infrared spectroscopy (fNIRS) and structural magnetic resonance imaging (sMRI).

Fitness promotion in college: the relationships among students' perceived physical literacy, knowledge, and physical fitness.

Purpose: The purpose of this study was to examine the relationships among perceived physical literacy (PPL), knowledge of physical activity and fitness (PAF knowledge), and physical fitness.

Methods: Undergraduates ( = 968, female = 414;  = 18.64) from a public university in central China completed a simplified Chinese version of the PPL instrument, an online test for PAF knowledge, and seven health-related physical fitness tests.

Evaluation of Wetting Behaviors of Liquid Sodium on Transition Metals: An Experimental and Molecular Dynamics Simulation Study.

In sodium-cooled fast reactors, the wettability of sodium with materials is closely related to sodium-related operations and the detection accuracy of instruments and meters, so how to achieve the selection of materials with different wettability requirements is a key problem in engineering design. To meet these requirements, the wetting behaviors of liquid sodium with nine transition metals were investigated using scanning electron microscopy (SEM), X-ray diffraction (XRD), and molecular dynamics (MD) simulations. The results show that metals such as zinc and gold, which react with sodium to form intermetallic compounds at the interface, exhibit superior wettability.

Total Synthesis and Antibacterial Evaluation of Lupinifolin and Its Natural Analogues.

In this study, lupinifolin () and its natural analogues, mundulin (), minimiorin (), khonklonginol H (), flemichin D (), and eriosemaone A (), were obtained by chemical synthesis for the first time. Key steps involved an electrocyclization to build the linear pyran rings and a Claisen/Cope rearrangement to install the 8-prenyl substituents. All compounds were assessed for their antimicrobial activities against clinically relevant human pathogens, including one Gram-negative bacterial strain ( ATCC 25922) and four Gram-positive bacterial strains ( ATCC 29213, ATCC 29212, MRSA21-5, and VRE ATCC 51299).

CyanoCyc cyanobacterial web portal.

CyanoCyc is a web portal that integrates an exceptionally rich database collection of information about cyanobacterial genomes with an extensive suite of bioinformatics tools. It was developed to address the needs of the cyanobacterial research and biotechnology communities. The 277 annotated cyanobacterial genomes currently in CyanoCyc are supplemented with computational inferences including predicted metabolic pathways, operons, protein complexes, and orthologs; and with data imported from external databases, such as protein features and Gene Ontology (GO) terms imported from UniProt.

Prediction of HER2 Expression in Gastric Adenocarcinoma Based On Preoperative Noninvasive Multimodal F-FDG PET/CT Imaging.

Rationale And Objectives: This study aims to investigate the role of a flourine-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) multimodal radiomics model in predicting the status of human epidermal growth factor receptor 2 (HER2) expression preoperatively in cases of gastric adenocarcinoma.

Materials And Methods: This retrospective study included 133 patients with gastric adenocarcinoma who were classified into training (n = 93) and validation (n = 40) cohorts in a ratio of 7:3. Features were selected using Least Absolute Shrinkage and Selection Operator and Extreme Gradient Boosting (XGBoost) methods; further, prediction models were constructed using logistic regression and XGBoost.

HIV gp120/Tat protein-induced epithelial-mesenchymal transition promotes the progression of cervical lesions.

Background: Human immunodeficiency virus (HIV) infection is associated with an elevated incidence of cervical cancer, and accelerated disease progression, but the underlying mechanisms are not well understood. This study aimed to investigate the relationship between HIV infection and epithelial-mesenchymal transition (EMT) in cervical cancer.

Methods: Tissue samples from HIV-positive and negative patients with cervical intraepithelial neoplasia (CIN) and cervical cancer were analyzed for EMT-related proteins.

Deep learning models of ultrasonography significantly improved the differential diagnosis performance for superficial soft-tissue masses: a retrospective multicenter study.

Background: Most of superficial soft-tissue masses are benign tumors, and very few are malignant tumors. However, persistent growth, of both benign and malignant tumors, can be painful and even life-threatening. It is necessary to improve the differential diagnosis performance for superficial soft-tissue masses by using deep learning models.

Total syntheses and antibacterial evaluations of cudraflavones A-C and related Flavones.

The total syntheses of the natural prenylated flavones cudraflavones A-C (1-3), artoheterophyllin D (28) and artelasticin (29) are reported, along with the evaluations of their antibacterial activities. The key steps of the synthesis involved a Baker-Venkataraman rearrangement and an intramolecular cyclization for the construction of the flavone core and the regioselective formation of the pyran and isopentenyl scaffolds. The tested natural flavones 1-3 and 27-29 exhibited potent activity against S.

Total Synthesis of Kuwanons A and B and Discovery of Their Antibacterial Mechanism.

Kuwanons A () and B () are two natural prenylated flavones isolated from the root bark of L. In this study, the first total syntheses of kuwanons A () and B () were achieved from a common intermediate with overall yields of 6.6% and 11.

Transcriptomic analysis of spinal cord regeneration after injury in .

Cynops orientalis (C. orientalis) has a pronounced ability to regenerate its spinal cord after injury. Thus, exploring the molecular mechanism of this process could provide new approaches for promoting mammalian spinal cord regeneration.

Effect of transdermal drug delivery therapy on anxiety symptoms in schizophrenic patients.

Objective: To evaluate the efficacy and safety of transdermal drug delivery therapy for schizophrenia with anxiety symptoms.

Methods: A total of 80 schizophrenic patients (34 males and 56 females) with comorbid anxiety disorders were randomly assigned to the treatment group ( = 40) and the control group ( = 40) with 6 weeks of follow-up. The patients in the treatment group received the standard antipsychotic drug treatment along with transdermal drug delivery therapy.

The value of postoperative radiotherapy in thymoma patients with myasthenia gravis.

Introduction: Surgery is the first-line treatment for patients with thymoma associated with myasthenia gravis (MG); however, the value of radiotherapy among these patients remains debatable. Herein, we examined the impact of postoperative radiotherapy (PORT) on the efficacy and prognosis of patients with thymoma and MG.

Methods: This retrospective cohort study included 126 patients with thymoma and MG who were enrolled in the Xiangya Hospital clinical database between 2011 and 2021.

Comparison of Corrosion Behavior of T91, 9Cr and 9CrAl ODS Steels in Liquid Pb.

It is important to improve the liquid lead corrosion resistance of fuel cladding alloy for promoting the development of lead-based reactors. The corrosion behaviors of traditional T91 steel and similar oxide dispersion strengthen ODS-type steels with or without the addition of Al, and were examined and compared at 600 °C in static oxygen-controlled liquid Pb in this research. High-temperature liquid lead corrosion tests were carried out for 120 h, 240 h, 500 h, 1000 h, and 2000 h, respectively, for three prepared samples.