Investigation of Cryptosporidium spp. and Enterocytozoon bieneusi in free-ranged livestock on the southeastern Qinghai-Xizang Plateau, China.

Background: Cryptosporidium spp. and Enterocytozoon bieneusi are zoonotic pathogens with global distribution, infecting humans and various livestock. For yaks, Tibetan sheep and horses, the traditional grazing models still hold a main position.

Exploration of the Prognostic Value of m5C Methylation Protein NOP2 and NSUN6 in Colon Cancer.

Colorectal cancer is a prevalent malignancy with high incidence and poor prognosis. This study explores the clinical significance of 5-methylcytosine RNA modification factors, specifically the NOP2/Sun RNA Methyltransferase (NSUN) family, in colorectal cancer. Utilizing data from The Cancer Genome Atlas database, we analyzed the expression levels of NSUN family members in tumor tissues, their prognostic relevance, and their relationship with immune cell infiltration.

Gilteritinib versus salvage chemotherapy in predominantly Asian patients with relapsed/refractory FLT3-mutated acute myeloid leukemia: a regional analysis of COMMODORE in China, South-East Asia, and Russia.

The COMMODORE study demonstrated the efficacy and safety of gilteritinib versus salvage chemotherapy (SC) treatment in a predominantly Asian population with relapsed/refractory (R/R) FMS-like tyrosine kinase 3 (FLT3)-mutated() acute myeloid leukemia (AML); here we present an exploratory analysis of the study stratified by region (China, South-East Asia and Russia). COMMODORE was a Phase 3, open-label, randomized (1:1), multicenter trial. There were 151, 50, and 33 patients in the China, South-East Asia, and Russia cohorts, respectively.

Mice Models for Peripheral Denervation to Enhance Vascular Regeneration.

Sympathetic innervation plays a critical role in regulating vascular function, yet its influence on vascular regeneration and reinnervation following ischemic injury remains poorly understood. This study develops and validates murine models of localized sympathetic denervation using 6-hydroxydopamine (6-OHDA) to enable study of the sympathetic nervous system's impact on vascular systems during tissue repair. Two methods of 6-OHDA administration were employed: a single topical application during open surgery and minimally invasive weekly subcutaneous injections.

NMR Based Methods for Metabolites Analysis.

Metabolite analysis is essential for understanding the biochemical processes and pathways that sustain life, providing insights into the complex interactions within cellular systems and clinical examinations. This review explores recent applications of nuclear magnetic resonance (NMR) spectroscopy in metabolite studies. Various methods enhancing analytical accuracy for metabolome profiling and metabolic pathway studies, including spectral simplification techniques, quantitative NMR, high-resolution MAS NMR, and isotopic labeling, are discussed.

7 I, a structurally modified sinomenine, exerts dual anti-GBM effects by inhibiting glioblastoma proliferation and inducing necroptosis which further mediates lysosomal cell death.

Background And Purpose: Glioblastoma multiforme (GBM) is an aggressive brain tumour which drug treatment has no overall significant effect on survival rate. Sinomenine is a natural product extracted from the traditional Chinese medicine Qingteng and was found to have a certain anti-tumour effect. Although, its short biological half-life, unstable physicochemical properties, large dosage and causes histamine release have hindered its use but it may form the basis for novel drug therapy of GBM.

Adaptive Descriptor Sliding-Mode Observer-Based Dynamic Event-Triggered Consensus of Multiagent Systems Against Actuator and Sensor Faults.

Actuator and sensor faults are among the most common factors affecting the stability of multiagent systems (MASs). This article proposes a dynamic event-triggered fault-tolerant control (FTC) algorithm based on descriptor sliding-mode observers to address actuator and sensor faults in MASs. First, the MAS dynamics are reformulated into a descriptor form, enabling an observer to simultaneously achieve state estimation and fault diagnosis.

Pyramid Network with Quality-Aware Contrastive Loss for Retinal Image Quality Assessment.

Captured retinal images vary greatly in quality. Low-quality images increase the risk of misdiagnosis. This motivates to design effective retinal image quality assessment (RIQA) methods.

Aeroengine Bearing Time-Varying Skidding Assessment With Prior Knowledge-Embedded Dual Feedback Spatial-Temporal GCN.

Bearing skidding is the primary factor restricting the development of aeroengines toward ultrahigh speed, low friction, and lightweight. Compared to typical bearing faults, analysis of bearing skidding presents greater challenges due to the weak signal properties, significant time-varying characteristics and coupling influence of multiple factors. It is crucial to fully utilize multisource signals to enhance skidding features and capture time-varying characteristics.

Study on the Effects of National Volume-Based Procurement of Chemical Drugs on Chinese Patent Medicines: Lipid-Lowering Drugs as an Example.

Background: Atherosclerotic cardiovascular disease remains the leading cause of death worldwide. This study aims to explore the impact of national volume-based procurement (NVBP) on Chinese patent medicines and provide evidence for improving policies and promoting rational drug use.

Methods: The study was based on data from the China National Health Insurance Agency that spanned January 2019 to December 2020.

Anterior segment anatomic parameters based on the scleral spur and cornea for risk profiling of primary angle-closure glaucoma.

Introduction: To investigate the anterior segment anatomical parameters associated with the scleral spur and cornea for risk profiling of primary angle-closure glaucoma (PACG).

Methods: A retrospective study was conducted, collecting parametric measurements obtained using CASIA 2 and IOLMaster 700. Univariate and multivariate logistic regression models were utilized to compare ocular parameters between the narrow angle (NA) group and PACG group, as well as identify risk factors for PACG.

Research on the Impact of an AI Voice Assistant's Gender and Self-Disclosure Strategies on User Self-Disclosure in Chinese Postpartum Follow-Up Phone Calls.

This study examines the application of AI voice assistants in Chinese postpartum follow-up phone calls, with particular focus on how interaction design strategies influence users' self-disclosure intention. A 2 (voice gender: female/male) × 3 (self-disclosure strategies: normal conversation without additional disclosure/objective factual disclosure/emotional and opinion-based disclosure) mixed experimental design (n = 395) was conducted to analyze how the gender and self-disclosure strategies of voice assistants affect users' stereotypes (perceived warmth and competence), and how these stereotypes, mediated by privacy calculus dimensions (perceived risks and perceived benefits), influence self-disclosure intention. The experiment measured various indicators using a 7-point Likert scale and performed data analysis through analysis of variance (ANOVA) and structural equation modeling (SEM).

Is the recurrence rate higher in obese patients undergoing inguinal hernia surgery?

Purpose: This study aimed to evaluate whether obese patients undergoing inguinal hernia repair surgery have a higher recurrence rate and compare the clinical outcomes of obese and non-obese patients.

Materials And Methods: The databases of PubMed, EMBASE, and Cochrane Library were used to search for eligible studies from inception to November 1, 2024. Mean difference (MD), Odds ratios (OR) and 95% confidence intervals (Cl) were pooled up to analyze.

Differences in plaque curvature in middle cerebral artery stenosis between acute stroke and non-acute stroke.

Background: The characteristics of plaques have a significant effect on the occurrence of stroke. This study aimed to examine the potential value of high-resolution magnetic resonance imaging (HR-MRI) in identifying symptomatic patients with middle cerebral artery (MCA) atherosclerotic plaques using plaque curvature.

Methods: In total, 107 patients with transient ischemic attack or ischemic stroke caused by unilateral MCA stenosis ranging from 50-99% were enrolled in this retrospective cross-sectional study from January 2020 to May 2024.

Constructing NiCo-hydroxide/Ni Mott-Schottky heterostructure electrocatalyst for enhanced alkaline hydrogen evolution reaction by inducing interfacial electron redistribution.

Designing and developing inexpensive and efficient catalysts for alkaline hydrogen evolution reaction (HER) applications is essential for the advancement of renewable energy. However, the inadequate charge transfer and higher energy barriers in the alkaline HER process resulted in limited HER efficiency. Herein, a novel highly efficient Mott-Schottky heterostructure catalyst was synthesized by rationally combining metallic Ni and nickel-cobalt layered double hydroxide (NiCo-LDH).

Effect of ultra-high pressure combined with heat-assisted treatment on the characterization, moisture absorption, and antioxidant activity properties of walnut peptide.

In this study, ultra-high pressure (UHP) and heat-assisted technology (HT) were used to process walnut peptides (WP) and investigate their combined effects (UHP-HT) on the characterization, moisture absorption, and antioxidant activity of WP. The results indicated that UHP (300 Mpa, 10 min) combined with HT treatment (55 °C, 30 min) significantly increased the surface hydrophobicity and disulfide bonds of WP. UHP-HT-treated WP exhibited lower moisture absorption and more stable water molecule migration.

A novel Pringle maneuver instrument for laparoscopic hepatectomy.

Background: The Pringle maneuver is a classic and commonly used technique in hepatectomy for bleeding control. However, it is not convenient to perform Pringle maneuver in laparoscopic hepatectomy. This study aimed to investigate the value of a novel blocking forceps designed by our center for the Pringle maneuver in laparoscopic hepatectomy.

Association between fibrinogen and cognitive impairment in patients with ischemic cerebrovascular disease.

Objectives: Fibrinogen has been reported as a potential risk factor for vascular dementia (VaD). However, the association between fibrinogen and cognition in patients with ischemic cerebrovascular disease (ICVD) has not been studied adequately. We aimed to examine the association of fibrinogen with cognitive impairment among patients with ICVD and to test whether white matter hyperintensities (WMH) and brain atrophy play a role under the association.

Synthesis and characterization of berberine-loaded nanoliposome for targeting of MAPK pathway to induce apoptosis and suppression of autophagy in glioblastoma.

Glioblastoma (GBM), the most aggressive and lethal primary brain tumor, demands innovative therapeutic strategies to improve patient outcomes and quality of life. Addressing this urgent need, our study focuses on developing a berberine (BBR)-loaded nanoliposome (NL) as a targeted drug delivery system to combat GBM. Synthesized using the thin film hydration method and characterized through advanced physical and spectroscopic techniques, these NLs demonstrate promising potential in enhancing BBR's therapeutic efficacy.

Application of needle electrodes in resection of single bladder tumor.

Background: Transurethral resection of bladder tumor is associated with some limitations when used in the diagnosis and treatment of non-muscle invasive bladder cancer.

Objectives: This study explored the application of needle electrodes in the transurethral resection of single bladder tumor (SBT) and highlighted the advantages of resection of bladder tumors.

Methods: A retrospective analysis was conducted on 79 patients with SBT treated at the Department of Urology, People's Liberation Army General Hospital, from January to December 2023.

Quantifying the impacts of volume-based procurement policy on spatial accessibility of antidepressants via generic substitution: A four-city cohort study using drug sales data.

Objective: To assess the spatial accessibility and inequality of antidepressants and its correlation with VBP (Volume-based procurement) policy using procurement data from four representative Chinese cities between 2018 and 2020.

Methods: The least-cost-path algorithm was employed to calculate travel time from each population point to the nearest medical institution. Gini coefficient and Theil index were utilized to measure accessibility and inequality.

Changes in eye axis length and corneal curvature in central China from the perspective of birth year.

Objectives: To explore the changes in eye structures over time in the Chinese population from the perspective of birth year.

Methods: We collected measurement data of intraocular lens Master from patients who underwent intraocular lens Master biometry for a routine cataract or refractive examination (ametropia and presbyopia) between April 2012 and October 2023, then screened them. Selected patients were divided into ten groups of 10 years each according to their year of birth (called birth decades).

Phyllanfranins A-F, anti-inflammatory ent-cleistanthane diterpenoids from Phyllanthus franchetianus.

A comprehensive chemical investigation of the EtOAc extract derived from the dried branches and leaves of Phyllanthus franchetianus H. Lév had successfully resulted to the isolation of six undescribed cleistanthane diterpenoids phyllanfranins A-F (1-6), along with three known compounds phyllarheophol C (7), phyacioid C (8), and spruceanol (9). The chemical structures of these compounds were elucidated by combined means of HRESIMS, 1D and 2D NMR spectra, together with ECD calculations.

Bioengineering Strategies for Treating Neointimal Hyperplasia in Peripheral Vasculature: Innovations and Challenges.

Neointimal hyperplasia, a pathological response to arterial interventions or injury, often leads to restenosis and recurrent narrowing or occlusion, particularly in the peripheral vasculature. Its prevalence and negative impact on the long-term success of vascular interventions have driven extensive research aimed at better understanding the condition and developing effective therapies. This review provides a comprehensive overview of emerging bioengineering strategies for treating neointimal hyperplasia in peripheral vessels.