Time-dependent diffusion MRI and kinetic heterogeneity as potential imaging biomarkers for diagnosing suspicious breast lesions with 3.0-T breast MRI.

Purpose: This study aimed to evaluate the diagnostic efficacy of time-dependent diffusion magnetic resonance imaging (td-dMRI) and dynamic contrast-enhanced MRI (DCE-MRI)-based kinetic heterogeneity in differentiating suspicious breast lesions (categorised as Breast Imaging Reporting and Data System 4 or 5).

Methods: This prospective study included 51 females with suspicious breast lesions who underwent preoperative breast MRI, including DCE-MRI and td-dMRI. Six kinetic parameters, namely peak, persistent, plateau, washout component, predominant curve type, and heterogeneity, were extracted from the DCE series using MATLAB and SPM software.

Indocyanine Green Fluorescence Plus Blue Dye for Sentinel Lymph Node Biopsy in Patients Undergoing Neoadjuvant Chemotherapy for Breast Cancer: A Multicenter, Prospective Cohort Study.

Background: Sentinel lymph node biopsy (SLNB) using radioisotope tracer plus blue dye is the gold standard after neoadjuvant chemotherapy (NAC) in initially cN1 breast cancer patients, but clinical use still has limitations. This study aims to examine diagnostic performance of dual indocyanine green (ICG) and methylene blue tracing for SLNB in patients who have completed NAC for breast cancer with initially cN1 disease.

Methods: Adult women (20-80 years of age) scheduled to undergo NAC for biopsy-proven cT0-3N1M0 primary invasive breast cancer were consecutively enrolled in this prospective, multicenter, cohort study.

Landscape of cardiorenal syndrome research: A bibliometric analysis.

To comprehensively review cardiorenal syndrome (CRS)-related research, this study analyzes its whole landscape and future trends from a bibliometric perspective. Using "cardiorenal syndrome" as the key word, a representative dataset of CRS was constructed in the Web of Science Core Collection (Science Citation Index Expanded) database up to November 2023. VOSviewer (version 1.

Tradeoff between productivity and stability across above- and below-ground communities.

An 11-year nitrogen addition experiment reveals that for both plants and soil microorganisms, the ruderal strategists had higher productivity but lower stability, while the tolerant strategists had higher stability and lower productivity, leading to the tradeoff between productivity and stability within and across above- and below-ground communities.

Construction of hydrocarbon belts based on macrocyclic arenes.

Hydrocarbon belts have garnered significant attention due to their intriguing structures, unique properties, and potential applications in supramolecular chemistry and materials science. However, their highly inherently strained structures pose challenges in their synthesis, and the resulting tedious synthesis strategies hinder their large-scale applications. Utilizing unstrained macrocyclic arenes as precursors presents an efficient strategy, allowing for a strain-induction step that mitigates the energy barrier associated with building strain in the formation of these belts.

A Pillararene-Based Cavitand: Synthesis and Solid-State Capsular Assemblies Induced by Linear Alkanes with Specific Lengths.

Herein, a novel pillararene-based cavitand with fixed planar chirality was synthesized by the SuFEx reaction. As demonstrated by single crystal X-ray analysis, host-guest capsules involving this cavitand and linear alkanes with specific lengths are observed in the solid state. The formation of each capsule is driven by hydrogen bonding interactions between a linear alkane molecule and two cavitand molecules, as well as noncovalent interactions between the two cavitand molecules in this capsule.

Pillar[5]arene-Based Ion-Pair Recognition for Encapsulation of a Stilbazolium-Type Dye with Enhanced Photophysical Properties and Nonlinear Optical Activity.

Constructing organic composite materials through molecular recognition has emerged as an important theme in materials science. Here we report an ion-pair recognition system involving the use of a propoxylated pillar[5]arene (PrP5) to modulate the solid-state photophysical properties of dye trans-4'-(dimethylamino)-N-methyl-4-stilbazolium hexafluorophosphate (DMASP). Single crystal X-ray diffraction analysis reveals that the dye guest DMASP is encapsulated by PrP5 to form a 2 : 1 host-guest complex 2PrP5⸧DMASP in the crystalline state.

Separation of cyclohexanol from cyclohexanol/cyclohexene mixtures by crystals of pillar[6]arene containing three benzoquinone units.

Here, we develop a new absorbent for efficient separation of cyclohexanol (CHA-ol) and cyclohexene (CHA-ene) by using crystals of pillar[6]arene with three benzoquinone units (P3QA). P3QA crystals are found to show remarkable selectivity for CHA-ol in 50 : 50 (v/v) CHA-ol : CHA-ene mixtures with a purity of 95.2%, along with vapochromic behavior.

High selective electrocatalytic reduction of carbon dioxide to ethylene enabled by regulating the microenvironment over Cu-Ag nanowires.

Copper-based tandem catalysts are effective candidates for yielding multi-carbon (C2+) products in electrochemical reduction of carbon dioxide (CORR). However, these catalysts still face a significant challenge regarding in the low selectivity for the production of a specific product. In this study, we report a high selectivity of 77.

Exosomal miR-361-3p promotes the viability of breast cancer cells by targeting ETV7 and BATF2 to upregulate the PAI-1/ERK pathway.

Background: Malignant progression is the major cause of poor prognosis in breast cancer (BC) patients. Plasma exosomal miRNAs have been reported to be involved in tumor progression, but their roles in BC remain unclear.

Methods: We performed plasma exosomal miRNA sequencing on 45 individuals, including healthy controls and nonmetastatic and metastatic BC patients.

- and Length-Selective Molecular Discrimination of Halogenated Organic Compounds by a Crystalline Hybrid Macrocyclic Arene.

The development of adsorbents with robust molecular discrimination capabilities for halogenated organic compounds (HOCs) holds significant importance due to their potential in adsorptive separation and mitigation of associated health risks. In this study, we report a molecular discrimination behavior based on crystalline hybrid macrocyclic arene , offering precise capture of - isomers and length-selective separation of HOCs. The activated crystals (α) demonstrate exceptional discrimination and separation performance by selectively capturing -1,2-dichloroethylene () from /-isomer mixtures with a high selectivity of 98.

Constructing a solid-state supramolecular polymer based on host-guest recognition between perethylated pillar[5]arene and tetrathiafulvalene.

Herein we present a novel linear supramolecular polymeric structure formed in both the solution and solid state, utilizing the host-guest recognition motif between perethylated pillar[5]arene and tetrathiafulvalene.

Peptidomimetics based on ammonium decasubstituted pillar[5]arenes: Influence of the alpha-amino acid residue nature on cholinesterase inhibition.

Cholinesterase inhibitors are a group of medicines that are widely used for the treatment of cognitive impairments accompanying Alzheimer's disease as well as for the treatment of pathological muscle weaknesses syndromes such as myasthenia gravis. The search for novel non-toxic and effective cholinesterase inhibitors for creating neuroprotective and neurotransmitter agents is an urgent interdisciplinary problem. For the first time, the application of water-soluble pillar[5]arenes containing amino acid residues as effective cholinesterase inhibitors was shown.

Pillar[5]arene-Based Fluorescent Supramolecular Polymers Without Conventional Chromophores.

Fluorescent supramolecular polymers have garnered significant attention due to their successful integration of supramolecular polymers and fluorescence, offering vast potential for applications in sensing, imaging, optoelectronics, and photonics. In this study, we present a novel supramolecular polymer based on P5-OH, derived from mono-substituted pillararene macrocycles. Notably, these formed supramolecular polymeric aggregates exhibit a prominent blue emission, representing a rare instance of fluorescent polymers devoid of conventional chromophores.

Clinicopathological features and prognosis of patients with HER2-low breast cancer.

Background: Low human epidermal growth factor receptor 2 (HER2) expression is an emerging concept in breast cancer that is defined as immunohistochemistry (IHC) 1 + or IHC 2 + and negative in situ hybridization (ISH) but has been poorly investigated. The aim of our study was to determine the frequency of low HER2 expression among HER2-negative breast cancers and compare the clinicopathological features and prognosis of HER2-low patients with those of HER2-zero patients.

Methods: We collected the data of 684 patients with primary HER2-negative breast cancer who underwent surgery between January 2012 and September 2021 from our self-built database.

Root Cause Analysis of Degradation in Protonic Ceramic Electrochemical Cell with Interfacial Electrical Sensors Using Data-Driven Machine Learning.

Protonic ceramic electrochemical cells (PCECs) offer promising paths for energy storage and conversion. Despite considerable achievements made, PCECs still face challenges such as physiochemical compatibility between componenets and suboptimal solid-solid contact at the interfaces between the electrolytes and electrodes. In this study, a novel approach is proposed that combines in situ electrochemical characterization of interfacial electrical sensor embedded PCECs and machine learning to quantify the contributions of different cell components to total degradation, as well as to predict the remaining useful life.

Efficient separation of monobromotoluene isomers by nonporous adaptive perbromoethylated pillar[5]arene crystals.

Herein we report an efficient adsorptive separation approach for monobromotoluene isomers using nonporous adaptive crystals of perbromoethylated pillar[5]arene (BrP5). The purity of separated -bromotoluene from an equal volume mixture of -bromotoluene and -bromotoluene reaches 96.6% in one cycle and the adsorbent BrP5 can be reused without losing separation performance.

Effect of different intensity exercises on cardiopulmonary function and quality of life of patients with chronic heart failure : A systematic review and meta-analysis.

Background: Exercise-based cardiac rehabilitation has positive benefits for patients with chronic heart failure (CHF), but the choice of exercise intensity has been controversial. The aim of this systematic review and meta-analysis was to investigate the effects of different exercise intensities on cardiopulmonary function and quality of life (QoL) of patients with CHF.

Methods: Randomized controlled trials (RCTs) of different exercise intensities applied to patients with CHF were searched in PubMed, Web of Science, the Cochrane Library, and Embase databases from inception to December 2021.

Carbon nanoparticles localized clipped node dissection combined with sentinel lymph node biopsy with indocyanine green and methylene blue after neoadjuvant therapy in node positive breast cancer in China: initial results of a prospective study.

Background: This study aimed to evaluate the feasibility of applying carbon nanoparticles (CNs) to visualize clip-marked metastatic nodes in combination with indocyanine green (ICG) and methylene blue (MB) as sentinel lymph node (SLN) tracers for targeted axillary dissection (TAD) after neoadjuvant therapy (NAT).

Methods: This feasibility trial enrolled 40 patients with node-positive breast cancer, and 38 patients completed NAT and surgery were included in the final analysis. Before NAT or surgery, clip-marked nodes were localized with CNs by ultrasonography.

PEGylated pH-responsive peptide-mRNA nano self-assemblies enhance the pulmonary delivery efficiency and safety of aerosolized mRNA.

Inhalable messenger RNA (mRNA) has demonstrated great potential in therapy and vaccine development to confront various lung diseases. However, few gene vectors could overcome the airway mucus and intracellular barriers for successful pulmonary mRNA delivery. Apart from the low pulmonary gene delivery efficiency, nonnegligible toxicity is another common problem that impedes the clinical application of many non-viral vectors.

A HD-ZIP transcription factor specifies fates of multicellular trichomes via dosage-dependent mechanisms in tomato.

Hair-like structures are shared by most living organisms. The hairs on plant surfaces, commonly referred to as trichomes, form diverse types to sense and protect against various stresses. However, it is unclear how trichomes differentiate into highly variable forms.

Efficacy and safety of endocrine therapy after mastectomy in patients with hormone receptor positive breast ductal carcinoma in situ: Retrospective cohort study.

Background: More than half of Chinese patients with hormone receptor positive (HR+) ductal carcinoma in situ (DCIS) are treated with mastectomy, and usually subjected to postoperative endocrine therapy (ET). Given that long-term ET can cause severe adverse effects it is important to determine the beneficial effect and safety of post-mastectomy ET on the disease-free survival (DFS) and adverse events in patients with HR+ DCIS.

Methods: To explore beneficial effect and safety of post-mastectomy ET in patients with HR+ DCIS, we performed a multicenter, population-based study.

Nanoencapsulation-Induced Second Harmonic Generation in Pillararene-Based Host-Guest Complex Cocrystals.

The features of molecularly preferable centrosymmetric arrangements exclude organic nonlinear optical (NLO) materials for second harmonic generation (SHG) when used in the solid and crystalline states, which greatly limits their applications in optoelectronic devices. Herein, a pillar[5]arene () is used as the macrocyclic host to encapsulate NLO molecules, 4-[4'-methoxystyryl]-1-methylpyridinium iodide (), 4-[2'-(5'-(dimethylamino)thiophen-2'-yl)vinyl]-1-methylpyridinium iodide (), and 4-methoxy-β-nitrostyrene (), to alter the solid-state packing of these NLO molecules and manipulate their centrosymmetric arrangements. forms 2:1 host-guest complexes with and , while it forms a 1:1 host-guest complex with .