Widefield ultra-high-density optical breast tomography system supplementing x-ray mammography.

We report a wide-field compressive diffuse optical tomography (DOT) system - optical mammography co-imager (OMCI) - which aims to augment tens of thousands of existing x-ray mammography or tomosynthesis systems worldwide by adding functional assessment of breast tissue and improve cancer diagnosis. The OMCI system utilizes large field-of-view structured light illumination and single-pixel-camera based detection techniques to produce ultra-high spatial sampling density while ensuring that the inverse problem remains compact via the development of a unique target-adaptive pattern optimization technique to achieve compressive-sensing based measurements. The reconstructed images can be further enhanced by applying a compositional-prior-guided DOT reconstruction algorithm with tissue structural priors derived from a separately acquired x-ray mammography scans.

The Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist Liraglutide Regulates Sirtuin-1-Mediated Neutrophil Extracellular Traps to Improve Diabetes-Induced Bone Metabolism Imbalance.

Background: Diabetes mellitus (DM) is a chronic metabolic disorder that disrupts normal bone remodeling.

Objectives: This study aimed to investigate how the glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide (LIR) addresses bone metabolism imbalances induced by type-II diabetes.

Methods: Type-II diabetic rat models were established through a single intraperitoneal injection of streptozotocin (STZ).

Pathogenesis and treatment of perioperative hiccups: a narrative review.

Introduction: Hiccups affect 0.05% of general in-patients and up to 10% of patients with gastroesophageal reflux disease. Hiccups are typically self-limited.

Chaihu Shugan San Exerts Antidepressant Effects by Regulating Glucocorticoid Metabolism in CUMS Rats and Network Pharmacology Provides Complementary Mechanistic Insights.

Traditional Chinese medicine Chaihu Shugan San (CSGS) is a classic Chinese herb prescription for improving depression, but its specific molecular mechanism has not been fully clarified. This study integrates network pharmacology and experimental validation to investigate CSGS's antidepressant effects, focusing on its impact on GC metabolism and related pathways. In this research, the antidepressant mechanism of CSGS in relation to the depression model induced by chronic unpredictable mild stress will be discussed.

Boronic acid-functionalized FeO nanoparticles for activity-preserved enrichment of low-abundance bacteria from real samples.

Pathogenic bacterial infections represent a significant and ongoing threat to public health. The development of a sensitive, convenient, and accurate method for diagnosing pathogenic bacteria is a formidable challenge due to their low abundance in complex biological samples, especially in the early stages of diseases. In this study, a kind of phenylboronic acid-functionalized FeO nanoparticles (NPs), known as FeO@poly(PEGDA--MAAPBA) NPs, was developed for effectively enriching low levels of pathogenic bacteria from complex samples and then diagnosing them through microbiological cultures.

Evaluation of risk factors for thromboembolic events in multiple myeloma patients using multiple machine learning models.

Venous thromboembolic events (VTE) is a frequent complication in multiple myeloma (MM) patients, raising mortality. This study aims to use machine learning to identify VTE risk factors in MM, helping to pinpoint high-risk individuals for better clinical management and prognosis. A retrospective analysis was conducted on the basic information, laboratory test results, treatment plans, and thrombosis prevention measures of 428 newly diagnosed MM patients at our hospital from December 2018 to December 2022.

Trends and burden of cardiovascular diseases among children and adolescents in China from 1990 to 2021.

Background And Aim: There are currently no reports on the burden and trends of cardiovascular disease among children and adolescents in China. This study aims to investigate the burden and epidemiological characteristics of Cardiovascular Diseases (CVD) within the Chinese population by analyzing the trends and burden of CVD among children and adolescents of different genders and age groups in China from 1990 to 2021.

Methods And Results: Utilizing data from the Global Burden of Diseases Study 2021, we estimated the incidence, mortality, and disability-adjusted life years (DALYs) associated with CVD among children and adolescents aged 0-19 years in China from 1990 to 2021.

Luminescence Investigation of Red Phosphors LaGaSnO:Eu with High Color Purity and Application in w-LEDs.

A series of newly synthesized red-emitting phosphors, LaGaSnO:Eu, were produced through high-temperature solid-state synthesis methods. The phase purity, particle morphology and optical properties were systematically investigated in this work. The prepared fluorescent material has high phase purity.

Quaternized and boronic acid dual-functional CoAg nanozymes for label-free, stable, sensitive, and rapid quantitation detection of the bacterial total concentration.

Background: Foodborne pathogenic bacteria lead to a significant increase in illnesses and fatalities annually. In the early stage of a pathogenic bacterial infection, the concentration of bacteria in food is lower than the detection limit of most technology which enhances the difficulty in diagnosis. It is a serious challenge for researchers to develop a rapid, sensitive, accurate, and stable pathogenic bacterial determination method without costly equipment and highly skilled operators.

Lipid metabolic remodeling delays senescence of T cells to potentiate their immunity against solid tumors.

Background: Tumor cells can drive the senescence of effector T cells by unbalancing their lipid metabolism, thereby limiting adoptive T cell therapy and contributing to tumor immune evasion. Our objective is to provide a feasible strategy for enhancing T cell treatment efficacy against solid tumors.

Methods: In this study, liposomal arachidonyl trifluoromethyl ketone (ATK) was anchored onto the adoptive T cell surface via bioorthogonal reactions, aiming to specifically inhibit the group IVA cytosolic phospholipase Aα (cPLAα), a key enzyme facilitating phospholipid metabolism and senescent state of T cells.

Allocentric and egocentric spatial representations coexist in rodent medial entorhinal cortex.

Successful navigation relies on reciprocal transformations between spatial representations in world-centered (allocentric) and self-centered (egocentric) frames of reference. The neural basis of allocentric spatial representations has been extensively investigated with grid, border, and head-direction cells in the medial entorhinal cortex (MEC) forming key components of a 'cognitive map'. Recently, egocentric spatial representations have also been identified in several brain regions, but evidence for the coexistence of neurons encoding spatial variables in each reference frame within MEC is so far lacking.

Targeting AURKA with multifunctional nanoparticles in CRPC therapy.

Castration-resistant prostate cancer (CRPC) presents significant therapeutic challenges due to its aggressive nature and poor prognosis. Targeting Aurora-A kinase (AURKA) has shown promise in cancer treatment. This study investigates the efficacy of ART-T cell membrane-encapsulated AMS@AD (CM-AMS@AD) nanoparticles (NPs) in a photothermal-chemotherapy-immunotherapy combination for CRPC.

Synthesis of SrLuAl(BO):Sm Red Phosphor with Excellent Thermal Stability and Its Application in w-LEDs.

In this study, a series of SrLuAl(BO):Sm red phosphors were successfully prepared with a high-temperature solid-phase technology. The Rietveld refinement analysis of the X-ray diffraction (XRD) diffraction patterns indicated that the as-prepared phosphors belong to the R3¯ space group of the hexagonal crystal system. Under 404 nm near-ultraviolet excitation, the SrLuAl(BO):Sm phosphor exhibits narrowband emission within the range of 550 to 750 nm.

Analysis of the bamboo SWEET gene family reveals that Dendrocalamus farinosus SWEET14 is involved in source-sink carbohydrate partitioning.

In higher plants, SWEET genes play a crucial role in source-sink carbohydrate partitioning. Dendrocalamus farinosus is an economic bamboo species because of its high fiber content and rapid growth. The transportation of photosynthetic products is essential for bamboo growth.

Novel Thermoplastic Polyurethanes Enable Biaxially Stretchable Conductor for Supercapacitors with High Areal Capacitance.

Stretchable supercapacitors are essential components in wearable electronics due to their low heat generation and seamless integration capabilities. Thermoplastic polyurethane elastomers, recognized for their dynamic hydrogen-bonding structure, exhibit excellent stretchability, making them well-suited for these applications. This study introduces fluorine-based interactions in the hard segments of thermoplastic polyurethanes, resulting in polyurethanes with a low elastic modulus, high fracture strength, exceptional fatigue resistance, and self-healing properties.

Synthesis and Luminescence Characterization of Novel Red-Emitting Phosphors Based on Eu-Activated KSr(MoO) Molybdates for w-LEDs.

In this work, trivalent europium (Eu) ion activated KSr(MoO) red phosphors have been synthesized through high-temperature solid-state reaction method at 750 ℃. Detailed analysis was conducted on the phase purity, morphology, and luminescence properties of the synthesized phosphors. X-ray diffraction (XRD) confirmed the successful formation of KSr(MoO):Eu phosphors with pure phase with space group С.

induces MST2 phosphorylation mediating the activation of hippo signaling pathway to promote apoptosis and lung tissue damage.

() is an intracellular parasite, and its regulation of host cell apoptosis directly affects its parasitism. Studies link -induced apoptosis to abnormal expression of mammalian STE20-like protein kinase 2 (MST2), but its precise role remains unclear. In this study, the regulatory roles in apoptosis and pathogenicity of infection were identified and .

Colorectal cancer screening using a multi-locus blood-based assay targeting circulating tumor DNA methylation: a cross-sectional study in an average-risk population.

Background: Effective screening for colorectal cancer (CRC) enables earlier diagnosis and intervention to improve patient survival.

Methods: In this study, we prospectively conducted a blood-based CRC screening program for community residents in Hanjiang District, Yangzhou City, and evaluated the screening efficacy of a blood-based multi-locus DNA methylation assay (ColonAiQ). The ColonAiQ-positive rate and colonoscopy participation rate of the population, detection rate of intestinal lesions, and positive predictive value (PPV) of CRC and advanced adenoma (AA) were calculated, and the associated factors were explored.

Dual-signal ratiometric electrochemical aptasensor for Zearalenone detection based on magnetic-assisted enrichment and hybridization chain reaction.

In this work, a dual-signal ratiometric electrochemical aptasensor based on the hybrid chain reaction (HCR) and streptavidin-modified magnetic beads (SA-MBs) was developed to rapidly detect zearalenone (ZEN). The HCR, as a powerful signal amplification technique to imporve the signal of sonser. When the target is present, they specifically bind with ZEN-Apt and release ZEN-cDNA to trigger HCR.

Endoscopic transnasal and transoral resection of the odontoid process and C1 combined with occipitocervical fusion for osteoradionecrosis of the upper cervical spine: a case report and literature review.

Background: Osteoradionecrosis (ORN) of the upper cervical spine is a rare but severe complication of head and neck cancer radiotherapy. To raise awareness of this condition, we describe a patient with a history of nasopharyngeal carcinoma who developed ORN of the upper cervical spine and review the published literature reporting surgical management.

Case Presentation: A 59-year-old female patient with persistent neck pain for one month and limited range of neck motion who had undergone radiotherapy for nasopharyngeal carcinoma with a total dose of 69.

Diabetic adverse events associated with three commonly used statins: a disproportionality analysis based on the FDA adverse event reporting system database.

Background: The increasing prevalence of statin use for cardiovascular disease management has raised concerns regarding their safety profile, particularly regarding the potential risk of diabetes. Our study aims to analyze diabetic adverse event reports related to statins using a large pharmacovigilance database to provide timely insights into this significant issue.

Methods: We analyzed data from the FDA Adverse Event Reporting System (FAERS) database from 2004 to 2023.

A comprehensive theoretical scheme for understanding the core structure and the mechanical behavior of basal dislocations with solute atmosphere in Mg alloys.

The basal dislocations play a key role in the deformation of hexagonal Mg alloys. However, its core structure and mechanical behavior have thus far not yet been understood adequately, largely owing to the fact that the basal dislocation, often decorated with segregated solute atmosphere and dissociated into two partials, cannot be modeled accurately. Significant discrepancies exist between theoretically calculated and experimentally observed structures for these dissociated dislocations.

Rosa roxburghii Tratt (Cili) has a more effective capacity in alleviating DSS-induced colitis compared to Vitamin C through B cell receptor pathway.

Rosa roxburghii Tratt (RRT), a traditional Chinese plant known as the 'King of Vitamin C (VitC; ascorbic acid, AsA)', contains a wealth of nutrients and functional components, including polysaccharides, organic acids, flavonoids, triterpenes, and high superoxide dismutase (SOD) activity. The various functional components of RRT suggest that it may theoretically have a stronger potential for alleviating colitis compared to VitC. This study aims to verify whether RRT has a stronger ability to alleviate colitis than equimolar doses of VitC and to explore the mechanisms underlying this improvement.