Semaglutide, a glucagon-like peptide-1 receptor agonist, inhibits oral squamous cell carcinoma growth through P38 MAPK signaling pathway.

Aims: Researches have shown that diabetes mellitus (DM) can promote the risk and progression of oral squamous cell carcinoma (OSCC). Semaglutide, a glucagon-like peptide-1 receptor agonist, is currently employed to treat type 2 diabetes mellitus (T2DM) and obesity. This study intends to explore the potential effects and mechanism of Semaglutide on OSCC.

Friends Across Time: Multi-Scale Action Segmentation Transformer for Surgical Phase Recognition.

Automatic surgical phase recognition is a core technology for modern operating rooms and online surgical video assessment platforms. Current state-of-the-art methods use both spatial and temporal information to tackle the surgical phase recognition task. Building on this idea, we propose the Multi-Scale Action Segmentation Transformer (MS-AST) for offline surgical phase recognition and the Multi-Scale Action Segmentation Causal Transformer (MS-ASCT) for online surgical phase recognition.

Gene mapping and candidate gene analysis of a sorghum sheathed panicle-I mutant.

Panicle exsertion is essential for crop yield and quality, and understanding its molecular mechanisms is crucial for optimizing plant architecture. In this study, the sheathed panicle-I (shp-I) mutant was identified from the ethyl methane sulfonate mutant population of the sorghum [Sorghum bicolor (L.) Moench] variety Hongyingzi (HYZ).

Endoscopic Ultrasound-Guided Brachytherapy of Yttrium-90 Implantation Into Pancreas: A Dose-Escalation Pilot Study.

Intratumoral brachytherapy enables higher dose treatment and reduces damage to adjacent tissues. We first validated the feasibility and safety of endoscopic ultrasound (EUS)-guided Yttrium-90 (Y) microspheres implantation in a porcine model. Under EUS guidance, Y-loaded microspheres were implanted into the pancreas of 10 miniature pigs.

Modulating HIF-1α/HIF-2α homeostasis with Shen-Qi-Huo-Xue formula alleviates tubular ferroptosis and epithelial-mesenchymal transition in diabetic kidney disease.

Ethnopharmacological Relevance: Diabetic kidney disease (DKD) is one of the main types of chronic kidney disease, which seriously affects the quality of life of patients. Shen-Qi-Huo-Xue formula (SQHXF), based on the Shen-Qi-Di-Huang decoction, is a traditional Chinese medicine formula for DKD. This study explored the mechanism of action of SQHXF on DKD through analysis of drug components, in vivo and in vitro experiments.

CircPRMT5, a Potential Salivary Biomarker, Facilitates the Progression of Head and Neck Squamous Cell Carcinoma via the IGF2BP3-SERPINE1 Pathway.

Purpose: Circular RNAs (circRNAs) are associated with the progression of tumors and hold promise as potential biomarkers for liquid biopsy. Among these, the role of circPRMT5 in head and neck squamous cell carcinoma (HNSCC) remains to be elucidated. This study aims to examine the role and underlying mechanisms of circPRMT5 in the progression of HNSCC and to assess its potential diagnostic value in saliva exosomes.

In-Pixel Dual-Band Intercorrelated Compressive Sensing Based on MoS/h-BN/PdSe Vertical Heterostructure.

Infrared-visible fused photodetection presents significant potential for target perception in complex scenarios. However, dual-band imaging inherently generates a considerable amount of redundant data, highlighting a pressing need to perform compressive sensing directly at the pixel level. Here, we report a photodetector composed of a MoS/h-BN/PdSe vertically stacked heterostructure with a common metal electrode interconnecting the bottom PdSe channel with the top MoS channel.

Perilipin2-dependent lipid droplets accumulation promotes metastasis of oral squamous cell carcinoma via epithelial-mesenchymal transition.

Emerging evidence shows that lipid metabolic reprogramming plays a vital role in tumor metastasis. The effect and mechanism of fatty acids and lipid droplets (LDs), the core products of lipid metabolism, on the metastasis of oral squamous cell carcinoma (OSCC), need further exploration. In this study, the influence of palmitic acid (PA) and oleic acid (OA) on the migration and invasion ability of OSCC cells was determined by in vitro experiments.

Melatonin-Loaded Hydrogel Modulates Circadian Rhythms and Alleviates Oxidative Stress and Inflammation to Promote Wound Healing.

Circadian rhythm disruption, commonly caused by factors such as jet lag and shift work, is increasingly recognized as a critical factor impairing wound healing. Although melatonin is known to regulate circadian rhythms and has potential in wound repair, its clinical application is limited by low bioavailability. To address these challenges, we developed an alginate-based dual-network hydrogel as a delivery system for melatonin, ensuring its stable and sustained release at the wound site.

Unveiling a Tunable Moiré Bandgap in Bilayer Graphene/hBN Device by Angle-Resolved Photoemission Spectroscopy.

Over the years, great efforts have been devoted in introducing a sizable and tunable band gap in graphene for its potential application in next-generation electronic devices. The primary challenge in modulating this gap has been the absence of a direct method for observing changes of the band gap in momentum space. In this study, advanced spatial- and angle-resolved photoemission spectroscopy technique is employed to directly visualize the gap formation in bilayer graphene, modulated by both displacement fields and moiré potentials.

Revealing the role of cancer-associated fibroblast senescence in prognosis and immune landscape in pancreatic cancer.

Cancer-associated fibroblasts (CAFs) represent a major contributor to tumor growth. Cellular senescence is a state of cell-cycle arrest characterized by a pro-inflammatory phenotype. The potential impact of CAF senescence on tumor progression and the tumor microenvironment (TME) remains to be elucidated.

Artificial Intelligence-Enabled Novel Atrial Fibrillation Diagnosis System Using 3D Pulse Perception Flexible Pressure Sensor Array.

Atrial fibrillation (AF) as one of the most common cardiovascular diseases has attracted great attention due to its high disability and mortality rate. Thus, a timely and effective recognition method for AF is of great importance for diagnosing and preventing it. Herein, we proposed a novel intelligent sensing and recognition system for AF which combined Traditional Chinese Medicine (TCM), flexible wearable electronic devices, and artificial intelligence.

Correlated Molecular Motion during Release of Residual Stress in Polymer Glassy Films.

Correlated molecular motion during the process of residual stress release in polymer glassy films is studied at the single-molecule level. Using poly(-butyl methacrylate) (PnBMA) and poly(vinyl acetate) (PVAc) as the model polymers, thin films fabricated by spin-casting without thermal annealing were chosen as samples for investigation. Single-molecule fluorescence defocused microscopy was used to track the rotational motion of the fluorescent probes doped inside the polymer films.

Impacts of Air Velocity Treatments Under Summer Conditions: Part III-Litter Characteristics, Ammonia Emissions, and Leg Health of Heavy Broilers.

The broiler industry is crucial for rural economies, but it faces challenges in enhancing animal performance and well-being, particularly due to heat stress and ammonia (NH) in grow-out houses. This study investigates the effectiveness of air velocity (AV) treatment in reducing heat stress and NH emissions while also improving litter conditions to enhance animal welfare. Conducted at the North Carolina State University's poultry engineering laboratory, the research used six identical controlled chambers, exposing broilers to High and Low AV treatments from 28 to 61 days across four flocks during the summers of 2017 and 2018.

Increased walking pace reduces the rate of erectile dysfunction: results from a multivariable Mendelian randomization study.

Background: Previous observational studies have identified a potential association between walking and the risk of erectile dysfunction (ED); however, the causal relationship between them remains unclear.

Aim: This study aims to explore the causal relationship between walking and ED using Mendelian randomization (MR).

Methods: MR analysis was conducted using genome-wide association study (GWAS) data related to walking pace.

Improving coalbed methane recovery in fragmented soft coal seams with horizontal cased well cavitation.

Effective coalbed methane extraction from soft coal seams is essential for mine safety and energy supply. To enhance the extraction efficiency of coal mine methane (CMM) and reduce the risk of gas outbursts in coal mining areas, we developed an original and innovate horizontal well hydraulic cavitation method. A mathematical model that can quantitatively optimize construction parameters and improve the effectiveness of engineering applications was also constructed to calculate the technological parameters of this construction method.

Brain age prediction and deviations from normative trajectories in the neonatal connectome.

Structural and functional connectomes undergo rapid changes during the third trimester and the first month of postnatal life. Despite progress, our understanding of the developmental trajectories of the connectome in the perinatal period remains incomplete. Brain age prediction uses machine learning to estimate the brain's maturity relative to normative data.

Characterisation of cytochrome c oxidase-coding genes from mung bean and their response to cadmium stress based on genome-wide identification and transcriptome analysis.

Background: Cytochrome c oxidase (COX) is a crucial mitochondrial enzyme in the electron transport chain of plants, implicated in energy production and stress responses. Despite its importance, the function of COX in leguminous plants, especially under heavy metal stress like cadmium (Cd), remains understudied.

Methods And Results: In this study, COX genes (COX s) were identified based on the genome annotation file in mung bean (Vigna radiata (Linn.

Establishing a new-onset diabetes-related metabolism signature for predicting the prognosis and immune landscape in pancreatic cancer.

New-onset diabetes (NOD) is a common condition among patients with pancreatic adenocarcinoma (PAAD) and is related to poor clinical outcomes. The potential impact of NOD on PAAD progression and the tumor microenvironment remains unclear. Here, we revealed that NOD in PAAD was associated with metabolic disorders.