Publications by authors named "Bimitha Benny"
Article Synopsis
- Biocontainment regulations require research on Nipah virus (NiV) to be carried out in BSL-4 labs, hindering studies on how the virus enters host cells and causes disease.
- The study developed HiBiT-tagged NiV virus-like particles (VLPs) that can be safely handled in BSL-2 labs, by co-expressing viral proteins in HEK293T cells, while maintaining similarities to the native virus.
- The HiBiT tag allows for rapid detection of viral interactions and effectiveness of neutralizing antibodies, providing a new, safer method for studying NiV assembly, binding, and entry, as well as for antibody neutralization assays.
