Publications by authors named "Bilyana C Popova"
Article Synopsis
- X chromosome inactivation is a process mammals use to balance X-linked gene expression between XX females and XY males, primarily regulated by the non-coding RNA Xist.
- Both sense and antisense RNA transcription can affect the methylation of the Xist promoter in embryonic stem cells, related to the decision of which X chromosome gets inactivated.
- The role of the RNA interference pathway in Xist regulation appears to be minimal, as changes in DNA methylation are likely linked to other factors, not directly influenced by RNAi mechanisms.
Attenuated spread of X-inactivation in an X;autosome translocation.
Proc Natl Acad Sci U S A
May 2006
X inactivation in female mammals involves transcriptional silencing of an entire chromosome in response to a cis-acting noncoding RNA, the X inactive-specific transcript (Xist). Xist can also inactivate autosomal sequences, for example, in X;autosome translocations; but here, silencing appears to be relatively inefficient. This variation has been attributed to either attenuated spreading of Xist RNA at the onset of X inactivation or inefficient maintenance of autosomal silencing.
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