J Racial Ethn Health Disparities
September 2024
Background: In the U.S., Black children have disproportionately elevated rates of pediatric morbidity compared with White children, but data are lacking for other countries.
View Article and Find Full Text PDFBackground: There is evidence that women with congenital anomalies are at risk of having an infant with the same defect. However, the risk of having an infant with a different type of defect is less well described.
Aims: We evaluated the extent to which offspring of women with congenital anomalies were at risk of having a birth defect, including defects that were similar to or different from their mother's.
Objectives: We investigated hospitalization and hospital mortality rates by cause during the first year of the COVID-19 pandemic in Quebec, Canada.
Study Design: Interrupted time series and decomposition analysis.
Methods: We analyzed hospital mortality during the first (February 25-August 22, 2020) and second waves (August 23, 2020-March 31, 2021), compared with 2019.
Background: The extent to which ambient air pollution contributes to the pathogenesis of congenital heart defects remains uncertain.
Objective: We investigated whether first trimester exposure to ambient fine particulate matter () and nitrogen dioxide () was associated with the risk of critical and noncritical heart defects in a large population-based cohort of births.
Methods: We carried out a retrospective cohort study of children conceived between 2000 and 2016 in Quebec, Canada.
Objectives: We assessed the relationship between hospital characteristics and risk of adverse birth outcomes among minority Anglophones in Montreal, Canada.
Methods: The study included 124,670 births among Anglophones in metropolitan Montreal between 1998 and 2019. We estimated risk ratios (RR) and 95% confidence intervals (CI) for the association between hospital characteristics, including residential proximity to hospitals and language in which medical services are provided, and risks of preterm birth and stillbirth.
J Child Psychol Psychiatry
August 2023
Background: Preterm birth may affect maternal mental health, yet most studies focus on postpartum mental disorders only. We explored the relationship between preterm delivery and the long-term risk of maternal hospitalization for mental illness after pregnancy.
Methods: We performed a longitudinal cohort study of 1,381,300 women who delivered between 1989 and 2021 in Quebec, Canada, and had no prior history of mental illness.
Objective: To evaluate the association between endometriosis and risk of severe maternal morbidity (SMM).
Methods: We conducted a population-based retrospective cohort study of 2,412,823 deliveries at hospitals in Quebec, Canada, between 1989 and 2019. The exposure was surgically confirmed endometriosis.
Background: We identified maternal and neonatal birth characteristics that were associated with organ or tissue transplants during childhood.
Methods: We designed a retrospective cohort study of the population of children born between 2006 and 2019 in Quebec, Canada. The exposure included birth complications such as congenital anomaly, neonatal blood transfusion, and oligohydramnios.
We assessed the association between fetal sex and the likelihood of marriage during pregnancy. We analyzed a cohort of 1,334,911 women who were unmarried at conception and had a live birth between 1990 and 2018 in Quebec, Canada. The exposure was fetal sex, determined by ultrasound.
View Article and Find Full Text PDFCancer Epidemiol Biomarkers Prev
October 2022
Background: Our objective was to assess whether hyperemesis gravidarum is associated with the risk of endodermal, mesodermal, and ectodermal human chorionic gonadotropin (hCG) receptor+ cancer in women.
Methods: We performed a longitudinal cohort study of 1,343,040 women who were pregnant between 1989 and 2019 in Quebec, Canada. We identified women with and without hyperemesis gravidarum and followed them over time to capture incident cancers, grouped by embryonic germ cell layer of origin and organ hCG receptor positivity.
Study Question: Do children whose mothers have polycystic ovary syndrome (PCOS) have an increased risk of morbidity?
Summary Answer: Maternal PCOS is associated with an increased risk of infection, allergy and other childhood morbidity.
What Is Known Already: PCOS is associated with higher rates of gestational diabetes, pre-eclampsia and preterm delivery, but the long-term impact on child health is poorly understood.
Study Design, Size, Duration: We conducted a retrospective longitudinal cohort study of 1 038 375 children in Quebec between 2006 and 2020.
Objective: To evaluate the association between assisted reproductive technology (ART) and offspring morbidity in the first decade of life.
Design: Longitudinal cohort study.
Setting: Provincial health registry in Quebec, Canada.
Importance: Causes of death in children with birth defects are poorly understood.
Objective: To determine mortality rates by cause of death in children with and without birth defects.
Design, Setting, And Participants: This longitudinal cohort study included a population-based sample of 1 037 688 children and was conducted in all hospitals in Quebec, Canada, with 7 700 596 person-years of follow-up between birth and age 14 years (April 1, 2006, to March 31, 2020).
Background: We examined the birth outcomes of children with inborn errors of metabolism detected at birth or later in life.
Methods: We carried out a retrospective cohort study of 1733 children with inborn errors of metabolism and 1,033,693 unaffected children born in Canada between 2006 and 2019. Primary outcomes included preterm birth, low birth weight, congenital anomalies, and other neonatal complications.
Background: Risk factors for paediatric inguinal hernia are poorly understood. This longitudinal cohort study assessed whether children with a maternal history of inguinal hernia or connective tissue disorders have a higher risk of developing inguinal hernias before 13 years of age.
Methods: The study included children followed up between birth and 13 years of age in Quebec, Canada, 2006-2019.
We studied the risk of myocardial infarction on Valentine's Day. We conducted a case-crossover study of 51,450 adults with myocardial infarctions in February, 1989-2019. The exposure was Valentine's Day, and the 2 days before and after Valentine's Day.
View Article and Find Full Text PDFObjective: We assessed whether bariatric surgery before pregnancy lowers the risk of severe maternal morbidity to a level comparable to no obesity.
Summary Of Background Data: Obesity is a risk factor for severe maternal morbidity, but the potential for bariatric surgery to reduce the risk has not been studied.
Methods: We analyzed a retrospective cohort of 2,412,075 deliveries between 1989 and 2019 in Quebec, Canada.
Paediatr Perinat Epidemiol
November 2021
Background: Data on fasting during Ramadan and the risk of preterm birth and child mortality are conflicting, but the association with stillbirth is unknown.
Objective: We studied the relationship between Ramadan and the risk of stillbirth for Arab women in Quebec, Canada.
Methods: We conducted a retrospective cohort study using birth certificates for Arab women in Quebec, Canada, between 1981 and 2017.