Foetidumins A-D, and other chemical constituents from Helichrysum foetidum (L.) Moench (Asteraceae) with antiparasite activity.

The phytochemical investigation of the MeOH and CHCl-MeOH (1:1) extracts from the flowers and twigs of Helichrysumfoetidum (L.) Moench (Asteraceae), which showed antileishmanial and antiplasmodial activities during the preliminary screening, led to the isolation of four undescribed compounds, including two ent-beyer-15-ene-type diterpenoids, foetidumins A (1) and B (2), one flavonoid, foetidumin C (3) and one chalcopyrone, foetidumin D (4). Additionally, fourteen known compounds comprising, two ent-beyer-15-ene-type diterpenoids (5-6), six flavonoids (7-12), two steroids (13-14), three triterpenoids (15-17), and one glyceryl monostearate (18) were also isolated.

Constituents of the Stem Bark of Linn. f. with Antileishmanial and Antibacterial Activities.

The chemical investigation of the -hexane fraction from the methanol extract of the stem bark of Linn f., which displayed good in vitro activity against NR-48822 promastigotes (IC 43.11 µg/mL), led to the isolation of three previously unreported polyprenylated benzophenones, guttiferone U (), V ()/W (), and a new tocotrienol derivative named globuliferanol (), along with 11 known compounds (-).

Desmoarylcoumarin and episoyasapogenol B: two new compounds from (Poir.) DC (Fabaceae).

A new 3-arylcoumarin, 7-hydroxy-6-(1,1-dimethylallyl)-2',5'-dihydroxy-4'-(3,3dimethylprenyl)-3-arylcoumarin (desmoarylcoumarin) , a previously unreported oleanane-type triterpenoid, 3,22,23-trihydroxyolean-12-en (episoyasapogenol B) , together with five known flavonoids including darbergioidin (), isoferreirin (), quercetin (), vitexin (), swertizin (), and one carbohydrate, sucrose () were isolated from the methanolic extract of the roots of . Their structures were elucidated mainly by extensive spectroscopic analysis (1D and 2D) and mass spectrometric (HRFAB-MS) data. The methanolic extract, EtOAc and -BuOH fractions as well as some isolated compounds were assessed for their antibacterial and antioxidant activities.

Antibacterial constituents of spreng and its emodin derivatives.

The CHCl-MeOH (1:1) extract of roots of (Polygonaceae) displayed significant antibacterial activity against five bacterial strains with MICs (62.5-31.2 μg.

Antimicrobial and Cytotoxic Activities of Constituents from the Fruit of L. Benth (Fabaceae).

Twenty-two compounds were isolated from the fruit of including one unprecedented, rare amino acid-derived zwitterionic and one new flavone derivative. The isolation was performed on repeated column chromatography over silica gel and their structures were determined by 1D-, 2D-NMR and HR-ESI-MS spectra together with reported data in the literature. The chemophenetic significance is also discussed.

In Vitro Antilipidic and Antithrombotic Activities of (Lamiaceae) Leaves Extracts and Fractions.

Objective: The present study investigated the effect of the leaves extracts and fractions of on the inhibition of pancreatic lipase, cholesterol esterase, adipocytes lipid uptake, and antithrombotic activity which may be important in atherosclerosis development.

Methods: Aqueous, ethanolic, and hydroethanolic extracts of were prepared by maceration. The hydroethanolic extract was fractionated into -hexane, ethylacetate, and butanol fractions and their inhibition of pancreatic lipase, cholesterol esterase, adipocytes lipid uptake, and antithrombotic activities measured.

A dihydrochalcone derivative and further steroidal saponins from Sansevieria trifasciata Prain.

Phytochemical investigation of the aerial parts of Sansevieria trifasciata, one of the most common Dracaenaceae plants, has resulted in the isolation of a new dihydrochalcone derivative named trifasciatine C (1), four previously unreported steroidal saponins as two pairs of inseparable regioisomers: trifasciatosides K/L (2/3), M/N (4/5), together with the known 1,2-(dipalmitoyl)-3-O-β-D-galactopyranosylglycerol (6), aconitic acid (7), and 1-methyl aconitic acid (8). Their structures were elucidated mainly by extensive spectroscopic analysis (1D and 2D nuclear magnetic resonance) and high-resolution electronspray ionization-mass spectrometry, as well as chemical methods and comparison of their spectral data with those of related compounds. Compounds 2/3 and 4/5 were evaluated for their antiproliferative activity on Hela cells, and no significant effect was observed.