Publications by authors named "Billi Dawn Applin"
SLMAP3 is a constituent of the centrosome and is known to assemble with the striatin-interacting phosphatase and kinase (STRIPAK) complex, where it has been reported to repress Hippo signalling. The global knockout of SLMAP3 in mice results in embryonic/perinatal lethality and stunted growth without changes in the phosphorylation status of YAP. Diverse phenotypes present in the SLMAP3 embryos include reduced body axis, small and abnormal organs resembling defects in planar cell polarity (PCP) signalling, while also displaying the notable polycystic kidneys, a known manifestation of ciliopathies.
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- * The absence of SLMAP3 leads to severe neural tube defects and abnormal neural plate dimensions in embryos, indicating problems with cellular processes like convergent extension critical for neural tube formation.
- * Proteomic analysis shows SLMAP3's interaction with cytoskeletal components and planar cell polarity (PCP) proteins, emphasizing its essential role in maintaining cytoskeleton organization and the PCP pathway during embryonic neurulation.