Publications by authors named "Bill Liao"
Article Synopsis
- Natural killer (NK) cells are vital in the body's defense against cancer, and new antibody formats that enhance their activation are showing promise for immunotherapy, particularly through antibody-dependent cell-mediated cytotoxicity (ADCC).
- Scientists have isolated two specific antibody clones, #1A2 and #2-2A2, that effectively target the CD16a receptor on NK cells without significantly affecting the related CD16b receptor on neutrophils, which may reduce unwanted side effects.
- These antibodies can be combined with other tumor-associated antigens as bispecific antibodies, leading to effective NK cell activation and tumor cell destruction, offering potential for innovative cancer treatments that are less impacted by circulating human IgG.
