Publications by authors named "Bill Jerrom"
Article Synopsis
- Only one-third of patients with depression respond fully to antidepressants, highlighting a need for effective strategies for those with treatment-resistant depression (TRD).
- The CoBalT trial aimed to assess the effectiveness and cost-effectiveness of adding cognitive behavioral therapy (CBT) to standard care for patients with TRD in primary care settings.
- The study involved a pragmatic, multicenter randomized controlled trial design, with follow-ups at multiple intervals to evaluate outcomes such as response and remission rates in participants receiving CBT alongside usual care compared to those receiving usual care alone.
Background: Depression is expensive to treat, but providing ineffective treatment is more expensive. Such is the case for many patients who do not respond to antidepressant medication.
Aims: To assess the cost-effectiveness of cognitive-behavioural therapy (CBT) plus usual care for primary care patients with treatment-resistant depression compared with usual care alone.
Background: Only a third of patients with depression respond fully to antidepressant medication but little evidence exists regarding the best next-step treatment for those whose symptoms are treatment resistant. The CoBalT trial aimed to examine the effectiveness of cognitive behavioural therapy (CBT) as an adjunct to usual care (including pharmacotherapy) for primary care patients with treatment resistant depression compared with usual care alone.
Methods: This two parallel-group multicentre randomised controlled trial recruited 469 patients aged 18-75 years with treatment resistant depression (on antidepressants for ≥6 weeks, Beck depression inventory [BDI] score ≥14 and international classification of diseases [ICD]-10 criteria for depression) from 73 UK general practices.
Background: Antidepressants are often the first-line treatment for depression but only one third of patients respond fully to pharmacotherapy. This paper describes the protocol for a randomised controlled trial (RCT) designed to evaluate the clinical and cost effectiveness of cognitive behavioural therapy (CBT) as an adjunct to pharmacotherapy for patients with treatment resistant depression in primary care.
Methods/design: CoBalT is a two parallel group multi-centre pragmatic RCT.