Background: Cranioplasty is a commonly performed neurosurgical procedure used to repair defects of the cranial vault. For large defects, 3D printing allows for the creation of patient-specific synthetic cranioplasties. Although these implants provide excellent cosmetic results for patients, costs are quite high.
View Article and Find Full Text PDFBackground: Central nervous system (CNS) lymphomas frequently pose a diagnostic challenge to physicians. CNS anaplastic large cell lymphoma (ALCL) is a rare condition. A majority (80%) of ALCLs harbour anaplastic lymphoma kinase 1 (ALK-1) mutation with only a minority testing negative for this mutation.
View Article and Find Full Text PDFCalcifying pseudoneoplasm of the neuraxis (CAPNON) is thought to be a rare tumefactive lesion with unknown pathogenesis. Its prevalence is questionable with few previously reported cases of incidental CAPNON, and likely underdiagnosis. We report a unique case of incidental multifocal CAPNON.
View Article and Find Full Text PDFBackground: Calcifying pseudoneoplasm of the neuraxis (CAPNON) is a rare tumefactive lesion. CAPNONs can mimic calcified meningiomas at the skull base.
Methods: Here, we report two cases of CAPNON and present a systematic review of the literature on skull base CAPNONs, to compare CAPNONs with calcified meningiomas.
Introduction: The Circle of Willis (CoW) is the most effective collateral circulation to the brain during internal carotid artery (ICA) occlusion. Carotid stump pressure (CSP) is an established surrogate measure of the cerebral collateral circulation. This study aims to use hemodynamic and computed tomography angiography measurements to determine the strongest influences upon the dependent variable, CSP.
View Article and Find Full Text PDFStudy Design: An original investigation that characterizes polyvinyl alcohol cryogel (PVA-C) in the context of the human lumbar intervertebral disc (IVD).
Objectives: To evaluate the mechanical properties of PVA-C under physiological conditions; to assess PVA-C's suitability as a key component in a tissue-mimicking artificial lumbar intervertebral disc; and to identify suitable formulations that mimic the nucleus pulposus and anulus fibrosus.
Summary Of Background Data: Current lumbar intervertebral disc prostheses provide suboptimal symptom relief and do not restore natural load-cushioning.