Prediction of Adverse Outcomes in Pediatric Acute Hematogenous Osteomyelitis.

Background: Clinicians cannot reliably predict complications of acute hematogenous osteomyelitis (AHO).

Methods: Consecutive cases of AHO from 2 pediatric centers in the United States were analyzed retrospectively to develop clinical tools from data obtained within 96 hours of hospitalization to predict acute and chronic complications of AHO. Two novel composite prediction scores derived from multivariable logistic regression modeling were compared with a previously published severity of illness (SOI) score, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) using area under the receiver operating characteristic curve analyses.