Publications by authors named "Bill D Geng"
The treatment of patients with metastatic prostate cancer (PCa) is considered to be a long‑standing challenge. Conventional treatments for metastatic PCa, such as radical prostatectomy, radiotherapy and androgen receptor‑targeted therapy, induce senescence of PCa cells to a certain extent. While senescent cells can impede tumor growth through the restriction of cell proliferation and increasing immune clearance, the senescent microenvironment may concurrently stimulate the secretion of a senescence‑associated secretory phenotype and diminish immune cell function, which promotes PCa recurrence and metastasis.
View Article and Find Full Text PDFGlial cell line-derived neurotrophic factor (GDNF) protects dopaminergic neurons in various models of Parkinson's disease (PD). Cell-based GDNF gene delivery mitigates neurodegeneration and improves both motor and non-motor functions in PD mice. As PD is a chronic condition, this study aims to investigate the long-lasting benefits of hematopoietic stem cell (HSC)-based macrophage/microglia-mediated CNS GDNF (MMC-GDNF) delivery in an MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model.
View Article and Find Full Text PDFArticle Synopsis
- Ferroptosis, a form of cell death, shows promise in overcoming chemoresistance in multiple myeloma (MM), but the role of bone marrow stromal cells (BMSCs) in this process is not fully understood.
- Research reveals that BMSCs make MM cells more sensitive to ferroptosis by increasing their iron levels, which activates steroid biosynthesis, particularly the production of lanosterol that contributes to reactive oxygen species (ROS) in these cells.
- The interaction between CD40 ligand and CD40 receptor is crucial for this process, as blocking this interaction reduces iron and lanosterol in MM cells, suggesting potential new treatments for patients with resistant MM.
Background: N-acetyltransferase 10 (NAT10) serves as a critical enzyme in mediating the N4-acetylcytidine (ac4C) that ensures RNA stability and effective translation processes. The role of NAT10 in driving the advancement of breast cancer remains uninvestigated.
Methods: We observed an increase in NAT10 expression, both at mRNA level through the analysis of the Cancer Genome Atlas (TCGA) database and at the protein level of tumor tissues from breast cancer patients.