The Turkish Version of the Revised Nottingham Sensory Assessment: Validity and Reliability in Chronic Stroke Survivors.

Background: Evaluation of sensory functions in chronic stroke survivors is essential to plan and implement effective treatment and rehabilitation.

Objective: To investigate the validity and reliability of the Turkish version of the Revised Nottingham Sensory Assessment (rNSA-T) in chronic stroke survivors.

Methods: We applied the World Health Organization's translation protocols to develop the rNAS-T.

Examining prestructured β-actin peptides as substrates of histidine methyltransferase SETD3.

The N-His73 methylation of β-actin by histidine methyltransferase SETD3 is required for the integrity of the cellular cytoskeleton. Modulation of SETD3 activity in human cells facilitates cancer-like changes to the cell phenotype. SETD3 binds β-actin in an extended conformation, with a conserved bend-like motif surrounding His73.

The effect of visual education aimed at the basic needs of individuals with disabilities on the health literacy and life quality of caregivers.

The aim of this research is to evaluate the effect of visual education for the basic needs of people with disabilities on the health literacy and life quality of caregivers. The study sample comprised 268 caregivers evaluated in a pretest-posttest pattern. The data were collected using a Personal Information Form, the Health Literacy Scale, and the World Health Organization [WHO] Life Quality Scale-Short Form.

The Turkish adaptation study of the professional identity scale.

Background: Professional identity encompasses the understanding of professional practices and the development of values and skills within a specific profession.

Objective: This study aimed to assess the suitability of the 9-item Macleod Clark Professional Identity Scale, originally developed by Adams et al. (2006), for Turkish culture and examine its psychometric properties in a sample of postgraduate nurses.

Variables that predict nurses' job stress and intention to leave during the COVID-19 pandemic in Turkey.

Aim: To investigate the variables predicting job stress and intention to leave the job among nurses during the COVID-19 pandemic in Turkey.

Design: This research was designed as an analytical cross-sectional study.

Methods: The population of the study consisted of 450 nurses working in a training and research hospital (N = 450).

Predictive Power of Self-Efficacy on the Fear of Childbirth in Pregnant Women: Underlying Mechanisms of Social Support as a Mediator and the COVID-19 Fear as a Moderator.

Background: Fear of childbirth (FOC) is a common problem associated with psycho-social factors in pregnant women.

Objectives: This study aimed to determine the mediator of social support and the moderator role of fear of coronavirus disease 2019 (COVID-19) in the relationship between self-efficacy and FOC in pregnant women.

Materials And Methods: This descriptive and cross-sectional study was conducted with 422 pregnant women registered in 18 family health centers.

The Burden and Quality of Life in Caregivers of Individuals With Stroke During the COVID-19 Pandemic in Turkey: A Cross-Sectional Study.

This study investigated the caregiving burden, quality of life and life satisfaction of caregivers of individuals with stroke during the pandemic period. A descriptive a study was performed with a sample of caregivers ( = 80) of inpatient individuals with stroke in Kayseri, Turkey. The Bakas Caregiving Outcomes Scale, Short Form Health Survey-36, and Temporal Satisfaction with Life Scale were used as well as some open-ended questions.

Top-down ion mobility/mass spectrometry reveals enzyme specificity: Separation and sequencing of isomeric proteoforms.

Enzymatic catalysis is one of the fundamental processes that drives the dynamic landscape of post-translational modifications (PTMs), expanding the structural and functional diversity of proteins. Here, we assessed enzyme specificity using a top-down ion mobility spectrometry (IMS) and tandem mass spectrometry (MS/MS) workflow. We successfully applied trapped IMS (TIMS) to investigate site-specific N-ε-acetylation of lysine residues of full-length histone H4 catalyzed by histone lysine acetyltransferase KAT8.

Reading and erasing of histone crotonyllysine mimics by the AF9 YEATS domain and SIRT2 deacylase.

Lysine acylations on histones and their recognition by chromatin-binding reader domains and removal by histone deacylases function as an important mechanism for eukaryotic gene regulation. Histone lysine crotonylation (Kcr) is an epigenetic mark associated with active transcription, and its installation and removal are dynamically regulated by cellular epigenetic enzymes. Here, we report binding studies and enzyme assays with histone H3K9 peptides bearing simplest Kcr analogs with varying hydrocarbon chain length, bulkiness, rigidity and polarity.

The Role of Trp79 in β-Actin on Histidine Methyltransferase SETD3 Catalysis.

N -methylation of His73 in actin by histidine methyltransferase SETD3 plays an important role in stabilising actin filaments in eukaryotes. Mutations in actin and overexpression of SETD3 have been related to human diseases, including cancer. Here, we investigated the importance of Trp79 in β-actin on productive human SETD3 catalysis.

Molecular Recognition of Methacryllysine and Crotonyllysine by the AF9 YEATS Domain.

Histone lysine methacrylation and crotonylation are epigenetic marks that play important roles in human gene regulation. Here, we explore the molecular recognition of histone H3 peptides possessing methacryllysine and crotonyllysine at positions 18 and 9 (H3K18 and H3K9) by the AF9 YEATS domain. Our binding studies demonstrate that the AF9 YEATS domain displays a higher binding affinity for histones possessing crotonyllysine than the isomeric methacryllysine, indicating that AF9 YEATS distinguishes between the two regioisomers.

Relationships between nurse managers' person-organization fit, person-job fit, and cultural values in Turkey.

Background: While individuals' thoughts and behaviors are shaped according to their environment's cultural characteristics, the managers' values also shape organizational culture. Therefore, the concepts of person-organization fit and person-job fit can also be affected by the managers' culture.

Objective: This research aimed to examine the relationships between organization, job fit and cultural values of nurse managers working in university hospitals in Turkey.

Investigation of in vitro histone H3 glycosylation using H3 tail peptides.

Posttranslational modifications (PTMs) on histone tails regulate eukaryotic gene expression by impacting the chromatin structure and by modulating interactions with other cellular proteins. One such PTM has been identified as serine and threonine glycosylation, the introduction of the ß-N-acetylglucosamine (GlcNAc) moiety on histone H3 tail at position Ser10 and Thr32. The addition of the ß-O-GlcNAc moiety on serine or threonine residues is facilitated by the O-GlcNAc transferase (OGT), and can be removed by the action of O-GlcNAcase (OGA).

Turkish validity and reliability of the individual cultural values scale on nurses.

Background: Nurses need to understand their own cultures in order to care for patients in ways that are based on the cultural structure of the patient, which means to the patient's cultural values and beliefs.

Aim: This study was conducted in Turkey, and the aim of the study was to test the Turkish validity and reliability of the Individual Cultural Values Scale (CVSCALE) for nurses.

Methods: This research was a methodological study.

Mortality in magnet hospitals: A systematic review.

Magnet hospitals are recognized for quality patient outcomes and nursing excellence. It was aimed to examine the effects of Magnet hospitals on mortality rate. Searches for this review were carried out using the PubMed, Scopus, and CINAHL databases without any year limitation.

Sleep-related Breathing Disorders in Children with Asthma: Impact on Asthma Control.

Objective: To investigate the frequency of sleep-related breathing disorder and the relationship between asthma control and sleep-related breathing disorder in children with persistent asthma.

Study Design: Comparative cross-sectional study.

Place And Duration Of Study: University of Health Sciences, Hamidiye Etfal Training and Research Hospital, Istanbul/Turkey, from January 2019 to June 2019.

Importance of Ile71 in β-actin on histidine methyltransferase SETD3 catalysis.

SETD3-catalysed -methylation of His73 in β-actin plays a key role in stabilisation of actin filaments in the metazoan cells. Overexpression and/or dysregulation of SETD3 is associated with several human pathologies, including cancer. Here, we examined the role of the Ile71 residue in β-actin on human SETD3 catalysis.

Dabigatran for stroke prevention in real life in a sample of population from Turkey: D-SPIRIT registry.

Objective: The D-SPIRIT registry is designed to investigate the safety and effectiveness of dabigatran etexilate in patients with atrial fibrillation in routine clinical practice.

Methods: D-SPIRIT is the first national, multicenter, prospective, observational, postmarketing registry that investigates the usage of dabigatran in real life. A total of 326 noveloral anticoagulant-eligible patients with atrial fibrillation who have been taking dabigatran etexilate therapy for stroke prevention at least 6 months from 9 different centers were enrolled into the registry.

Enhanced water stability and high CO storage capacity of a Lewis basic sites-containing zirconium metal-organic framework.

Metal-organic frameworks (MOFs) are an emerging class of materials employed for custom-designed purposes by judicious selection of linkers and metal ions. Among the MOFs composed of carboxylate linkers, Zr-based MOFs have attracted great attention due to their high thermal and chemical stabilities, which are important for practical applications, including capturing CO from a point source. UiO-67(bipy) containing 2,2'-bipyridine-5,5'-dicarboxylate is particularly useful among the Zr-MOF family due to the Lewis basic sites of the linker; however, the hydrolytic stability of UiO-67(bipy) does not seem to be as high as those of UiO-66 and UiO-67.

A Case of Smith-Lemli-Opitz Syndrome Diagnosed with Hypertrophic Pyloric Stenosis.

Smith-Lemli-Opitz syndrome (SLOS) is caused by a deficiency in the enzyme 7-dehydrocholesterol reductase (DHCR7) that results in an abnormality in cholesterol metabolism. SLOS is inherited as an autosomal recessive genetic disorder. In this case, we describe a 34-day-old patient with postnatal progressive projectile vomiting, diagnosed with hypertrophic pyloric stenosis, who was suspected to have SLOS during treatment clinical and biochemical profile.

Assessment of internet usage for health-related information among clients utilizing primary health care services.

Objective: This study aimed to identify the frequency and goals of Internet usage to access health-related information among primary health care service clients.

Methods: The study was conducted in a primary health care centre with a sample of 788 adults. The data were collected through a questionnaire developed by the researchers.

Estimation of the Balance-Keeping Control Law Applied by a Human Being Upon a Sudden Sagittal Tilt Perturbation.

This study aims to estimate the control law employed by the central nervous system (CNS) to keep a person in balance after a sudden disturbance. For this aim, several experiments were carried out, in which the subjects were perturbed sagittally by using a single-axis tilt-platform and their motions were recorded with appropriate sensors. The analysis of the experimental results leads to the contribution of this paper as a conjecture that the CNS commands the muscular actuators of the joints according to an adaptive proportional-derivative (PD) control law such that its gains and set points are updated continuously.