Mental health service utilization among patients followed up in tertiary HIV/AIDS clinics in Turkey: A need for integrated care.

Objectives: Mental health (MH) care for people living with HIV (PLWH) emerges as an important unmet need, yet there are no integrated HIV-MH clinics in Turkey. Our aim is to determine MH service use and its associated factors in PLWH followed up in the HIV/AIDS outpatient clinics in Istanbul/Turkey.

Methods: A cross-sectional study was conducted at the HIV/AIDS outpatient clinics of the Infectious Diseases (ID) departments in hospitals affiliated with the ACTHIV-IST Study Group.

The relationship between ghrelin and inflammation in diabetic rat stomach.

Background: Ghrelin is a hormone that regulates the digestive system, as well as has immunomodulating effects. The aim of this study is to explain effects of ghrelin on inflammation and oxidative stress parameters in the stomach.

Methods: Male Sprague Dawley rats 8-10 weeks old (n = 21) were randomly divided into three groups as control, type 2 diabetes (T2DM) and diabetes and given exogenous ghrelin (T2DM+Gh).

Human immunodeficiency virus type 1 impairs sumoylation.

During infection, the human immunodeficiency virus type 1 (HIV-1) manipulates host cell mechanisms to its advantage, thereby controlling its replication or latency, and evading immune responses. Sumoylation is an essential post-translational modification that controls vital cellular activities including proliferation, stemness, or anti-viral immunity. SUMO peptides oppose pathogen replication and mediate interferon-dependent anti-viral activities.