Publications by authors named "Bilge Gungoren"
Nanotechnology offers significant advantages for medical imaging and therapy, including enhanced contrast and precision targeting. However, integrating these benefits into ultrasonography is challenging due to the size and stability constraints of conventional bubble-based agents. Here bicones, truly tiny acoustic contrast agents based on gas vesicles (GVs), a unique class of air-filled protein nanostructures naturally produced in buoyant microbes, are described.
View Article and Find Full Text PDFNanotechnology offers significant advantages for medical imaging and therapy, including enhanced contrast and precision targeting. However, integrating these benefits into ultrasonography has been challenging due to the size and stability constraints of conventional bubble-based agents. Here we describe bicones, truly tiny acoustic contrast agents based on gas vesicles, a unique class of air-filled protein nanostructures naturally produced in buoyant microbes.
View Article and Find Full Text PDFArticle Synopsis
- Circulating tumor DNA (ctDNA) is not very effective for detecting molecular residual disease (MRD) in bladder cancer, so researchers turned to analyzing urine samples instead.
- They used advanced sequencing techniques on urine tumor DNA from 74 patients, finding that urine-derived DNA markers were much better at predicting MRD than blood ctDNA.
- Their model showed 87% sensitivity for predicting residual disease and highlighted that patients identified with MRD had significantly worse outcomes in both progression-free and overall survival.