Melatonin decreases apoptosis in gastric mucosa during aging.

Background And Aims: The aging process of tissues is usually accompanied by an increased rate of apoptosis. Although melatonin has been reported to delay aging by scavenging free radicals, its role in the aging of gastric mucosa is not known. In this study, we examined the effects of exogenous melatonin (MLT) on the caspase-dependent apoptosis of gastric mucosa during aging.

The role of melatonin on gastric mucosal cell proliferation and telomerase activity in ageing.

Despite antiproliferative effects of melatonin on cultured tumor cells, its effects on normal cells are less clear. The action of melatonin on telomerase activity in ageing of gastric mucosal tissues also is not known. In this study, we investigated the age-related changes in telomerase activity and cellular proliferation rate of gastric mucosa and the effect of melatonin.

Exogenous melatonin decreases age-induced lipid peroxidation in the brain.

Aging has been proposed as the major risk factor in most neurodegenerative disorders. Oxidative stress is one of the widely accepted hypotheses to explain the pathogenesis of the senescence-related disorders. In this research report we aimed to study the changes in the levels of malondialdehyde as an indicator of lipid peroxidation and glutathione (GSH) of anti-oxidant status during aging.

The effect of vaginal candidiasis on the levels of the oxidative biomarkers in plasma and tissue samples of diabetic rats.

The aim of this study is to determine the relation between diabetes and vaginal candidiasis in terms of oxidative biomarker levels in a vaginal candidiasis model of the diabetic rats by evaluating malondialdehyde (MDA), sulphydrile groups or glutathione (RSH), and ascorbic acid (C vit) levels. All rats were randomly divided into five groups. All of the groups were observed for 21 days.

The effect of repeated tryptophan administration on body weight, food intake, brain lipid peroxidation and serotonin immunoreactivity in mice.

Tryptophan as a circulating precursor of serotonin (5-HT) may suppress food intake and body weight. Tryptophan administration can enhance the generation of reactive oxygen species (ROS) by inducing oxidative pathway in vivo and in vitro. We have examined the effect of repeated tryptophan administration on food consumption, body weight, brain lipid peroxidation and 5-HT immunoreactivity.

Effects of dexfenfluramine on serotonin levels of mice ileum, contractility, glutathione and malondialdehyde level.

Unlabelled: Dexfenfluramine is one of the anorectic drugs that suppresses food intake which acts via inhibition of reuptake of serotonin into brain terminal. Gastrointestinal tract is the main source of peripheral serotonin which is involved in the regulation of gastrointestinal motility. During the use of anorectic drugs, the antioxidant defence is affected especially by reactive oxygen species.

The effects of vitamin C supplementation on oxidative stress and antioxidant content in the brains of chronically exercised rats.

The purpose of this study was to ascertain whether vitamin C supplementation during chronic exercise training alters rat brain antioxidant content. Female Wistar albino rats were exercised on a treadmill for 30 min/day for 6.5 weeks and were administered daily intraperitoneal injections of vitamin C (20 mg/kg).

Plasma level of lipid peroxidation, total sulphydryl groups and nitric oxide levels in cancer patients irradiated on different anatomic fields: a case-control study.

Aim: The aim of this study was to evaluate the effect of radiotherapy on lipid peroxidation, total sulfhydryl groups (RSH) and nitric oxide (NO radical) levels in plasma of cancer patients treated on different anatomic sites, and to compare the results with control subjects.

Methods: 89 patients with various malignancies and 33 healthy control subjects were recruited for the study. Cancer patients were grouped according to the irradiation portals (head and neck, thoracic, breast, abdominal and pelvic).

The role of transforming growth factor alpha formulation on aspirin-induced ulcer healing and oxidant stress in the gastric mucosa.

Purpose: Transforming growth factor (TGF) alpha accelerates wound healing, especially in gastric ulcers. Transforming growth factor alpha can be affected by acid and pepsin in the gastric juice. Oxidative stress also plays a role in the formation of gastric lesions.

Effects of simvastatin treatment on oxidant/antioxidant state and ultrastructure of streptozotocin-diabetic rat lung.

In the present study, we investigated the effects of simvastatin, a 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitor, on lipid metabolism, lipid peroxidation, antioxidant enzyme activities and ultrastructure of diabetic rat lung. Diabetes was induced by a single injection of streptozotocin (45 mg kg(-1), i.p.

Relationships between tensile strength, ascorbic acid, hydroxyproline, and zinc levels of rabbit full-thickness incision wound healing.

Purpose: This work was carried out to follow up the healing of full-thickness incision wounds opened on the back skin of rabbits in order to gain insight into the periodical correlation among such factors as ascorbic acid, collagen (hydroxyproline), the zinc content, and tensile strength of wound tissue. The need to provide vitamin C or zinc supplements after such wound incisions is also discussed.

Methods: Full-thickness incision wounds and the ascorbic acid and hydroxyproline levels were measured in 24 rabbits by spectrophotometric methods on day 0 and on the 3rd, 5th, 7th, and 15th days after operation.

The role of epidermal growth factor formulation on stress ulcer healing of the gastric mucosa.

Purpose: We investigated the role of epidermal growth factor (EGF) microemulsion (ME) formulation on stress ulcer healing and the levels of gastric mucosal malondialdehyde (MDA) and glutathione (GSH).

Methods: Forty-eight female Wistar rats were divided into five groups according to the treatments given. Ten rats were given intragastric (i.

Effects of epidermal growth factor microemulsion formulation on the healing of stress-induced gastric ulcers in rats.

The effects of intragastric (i.g.) administration of microemulsion formulation of epidermal growth factor (EGF) on the healing of acute gastric ulcers induced by cold-restraint stress in rats was studied and compared with intraperitoneal (i.