Publications by authors named "Bilade Cherqaoui"
Article Synopsis
- HLA-B27's association with spondyloarthritis (SpA) has been studied for 50 years, revealing its impact on the bone morphogenetic protein (BMP) pathway in Drosophila, which leads to a specific phenotype.
- Researchers investigated the genetic interactions between the TGFβ pathway and HLA-B27 in transgenic Drosophila and identified key interactions in T cells from HLA-B27/hβ2m rats.
- The study found that both the TGFβ and BMP pathways are deregulated in the context of HLA-B27, leading to increased phosphorylation of SMAD proteins and changes in gene expression related to immune responses.
Introduction: In spondyloarthritis (SpA), an increased type 3 immune response, including T helper cells (Th) 17 excess, is observed in both human and SpA animal models, such as the HLA-B27/human β2-microglobulin transgenic rat (B27-rat).
Methods: To investigate this unexplained Th17-biased differentiation, we focused on understanding the immunobiology of B27-rat naive CD4 T cells (Tn).
Results: We observed that neutrally stimulated B27-rat Tn developed heightened Th17 profile even before disease onset, suggesting an intrinsic proinflammatory predisposition.
Introduction: Spondylarthritis (SpA) development in HLA-B27/human β2-microglobulin transgenic rat (B27-rat) is correlated with altered conventional dendritic cell (cDC) function that promotes an inflammatory pattern of CD4+T cells, including a biased expansion of pro-inflammatory Th population and imbalance of regulatory T cells cytokine profile. Transcriptomic analysis revealed that cDCs from B27-rats under express IL-27, an anti-inflammatory cytokine which induces the differentiation of IL-10 regulatory T cells and inhibits Th cells.
Methods: Here, we first investigated whether addition of exogenous IL-27 could reverse the inflammatory pattern observed in CD4 T cells.
Article Synopsis
- - Axial spondyloarthritis (AxSpA) is an inflammatory condition affecting joints and related tissues, with key factors like abnormal CD4 T cell differentiation and a heightened type 3 immune response playing a significant role in its development and treatment strategies.
- - New therapies are being explored, including interleukin (IL)-17 and Janus kinase inhibitors, which target pathways beyond the traditional tumor necrosis factor-α inhibition, with several promising drug targets identified through preclinical and clinical research.
- - Future treatment approaches may focus on modulating key immune pathways and using advanced technologies like multiomics and artificial intelligence to better identify suitable targets and tailor therapies for individual patients.
Objective: To better define the clinical distinctions between the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related paediatric inflammatory multisystem syndrome (PIMS) and Kawasaki disease (KD).
Methods: We compared three groups of patients: group 1, cases from our national historic KD database (KD-HIS), before the SARS-CoV-2 pandemic; group 2, patients with KD admitted to an intensive care unit (KD-ICU) from both our original cohort and the literature, before the SARS-CoV-2 pandemic; and group 3, patients with PIMS from the literature.
Results: KD-HIS included 425 patients [male:female ratio 1.
Understanding the complex mechanisms underlying a disorder such as spondyloarthritis (SpA) may benefit from studying animal models. Several suitable models have been developed, in particular to investigate the role of genetic factors predisposing to SpA, including HLA-B27, ERAP1, and genes related to the interleukin (IL)-23/IL-17 axis. One of the best examples of such research is the HLA-B27 transgenic rat model that fostered the emergence of original theories regarding HLA-B27 pathogenicity, including dysregulation of innate immunity, contribution of the adaptive immune system to chronic inflammation, and influence of the microbiota on disease development.
View Article and Find Full Text PDFObjective: Anakinra has been shown to be successful in preventing and treating cardiovascular lesions both in experimental murine models of Kawasaki disease (KD) and in several studies on intravenous immunoglobulin (IVIG)- and steroid-resistant patients with KD. This study was undertaken to determine the safety of blocking interleukin-1 in patients with IVIG-resistant KD.
Methods: Sixteen patients were included in the present study.
Spondyloarthritis (SpA) is a chronic inflammatory disorder resulting from a combination of genetic predisposition and environmental factors. Despite recent advances, a substantial fraction of its genetic basis remains poorly understood. Several mechanisms have been proposed to account for this unexplained heritability, including epigenetics which can play a role at the interface between genetic and environmental susceptibility factors.
View Article and Find Full Text PDFObjectives: Children with Familial Mediterranean fever may suffer from musculoskeletal involvement, somewhat difficult to distinguish from juvenile spondyloarthritis. The association of these two diseases has been scarcely reported in children. Objective of this work was to define the association of familial Mediterranean fever and juvenile spondyloarthritis in France.
View Article and Find Full Text PDFBackground: Apheresis is a major challenge in peripheral stem cell collection from low-weight children with cancer. Comparisons between the new apheresis device Optia (TerumoBCT) and the earlier COBE Spectra (CaridianBCT) have been performed in adults but not in low-weight children. The objective was to compare the performance of these two devices in small children.
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