Flavin Nitroalkane Oxidase Mimics Compatibility with NOx/TEMPO Catalysis: Aerobic Oxidization of Alcohols, Diols, and Ethers.

Biomimetic flavin organocatalysts oxidize nitromethane to formaldehyde and NO-providing a relatively nontoxic, noncaustic, and inexpensive source for catalytic NO for aerobic TEMPO oxidations of alcohols, diols, and ethers. Alcohols were oxidized to aldehydes or ketones, cyclic ethers to esters, and terminal diols to lactones. In situ trapping of NO and formaldehyde suggest an oxidative Nef process reminiscent of flavoprotein nitroalkane oxidase reactivity, which is achieved by relatively stable 1,10-bridged flavins.

Nanovolume Gas-Free Hydroxide Eluent Generator for Open Tubular Ion Chromatography.

A gas-free KOH eluent generator (EG) with 210 nL of internal volume is described. It utilizes a two-membrane configuration where there is a single CEM layer on one side and a single BPM layer on the other side for use in open tubular ion chromatography systems with typical back pressures < 50 psi. At a flow rate of ∼190 nL/min, the 10-90% gradient rise time is 3.

Direct Photothermal Measurement of Optical Absorption in a Flow System.

We describe here a simple photothermal detection scheme in a flow stream based on the temperature difference upstream and downstream of the point of illumination. We use a single, two-junction 25 μm diameter thermocouple to measure the temperature change. The baseline standard deviation in the dark is ∼0.

Capillary Scale Admittance and Conductance Detection.

Admittance detection, more commonly called capacitively coupled contactless conductivity detection, is widely used. While the true conductance of a solution is linear with concentration up to ∼1 mequiv/L, the admittance signal is nonlinear. In small-bore capillaries and highly resistive solutions, such as in suppressed open tubular ion chromatography (SOTIC), the admittance signal is exponentially related to concentration.