Accuracy of an MR-only workflow for prostate radiotherapy using semi-automatically burned-in fiducial markers.

Background: The benefit of MR-only workflow compared to current CT-based workflow for prostate radiotherapy is reduction of systematic errors in the radiotherapy chain by 2-3 mm. Nowadays, MRI is used for target delineation while CT is needed for position verification. In MR-only workflows, MRI based synthetic CT (sCT) replaces CT.

Genotype and phenotype of 101 dutch patients with congenital stationary night blindness.

Objective: To investigate the relative frequency of the genetic causes of the Schubert-Bornschein type of congenital stationary night blindness (CSNB) and to determine the genotype-phenotype correlations in CSNB1 and CSNB2.

Design: Clinic-based, longitudinal, multicenter study.

Participants: A total of 39 patients with CSNB1 from 29 families and 62 patients with CSNB2 from 43 families.

Assessment of night vision problems in patients with congenital stationary night blindness.

Congenital Stationary Night Blindness (CSNB) is a retinal disorder caused by a signal transmission defect between photoreceptors and bipolar cells. CSNB can be subdivided in CSNB2 (rod signal transmission reduced) and CSNB1 (rod signal transmission absent). The present study is the first in which night vision problems are assessed in CSNB patients in a systematic way, with the purpose of improving rehabilitation for these patients.

Crowding ratio in young normally sighted children.

Purpose: To determine normal values of the crowding ratio (CR) in children.

Methods: Of 62 normally sighted primary school children aged 4-12 years old the CR was determined both for distance and near vision. The examinations were performed using commonly available test charts based on the LEA symbols.

An extended 15 Hz ERG protocol (2): data of normal subjects and patients with achromatopsia, CSNB1, and CSNB2.

The amplitude versus flash strength curve of 15 Hz electroretinograms (ERGs) shows two minima. The minima are caused by interactions between the primary and the secondary rod pathways (first minimum), and the secondary rod pathway and the cone-driven pathway (second minimum). Furthermore, cone pathway contributions cause higher-order harmonics to occur in the responses.

An extended 15 Hz ERG protocol (1): the contributions of primary and secondary rod pathways and the cone pathway.

The minimum in the amplitude versus flash strength curve of dark-adapted 15 Hz electroretinograms (ERGs) has been attributed to interactions between the primary and secondary rod pathways. The 15 Hz ERGs can be used to examine the two rod pathways in patients. However, previous studies suggested that the cone-driven pathway also contributes to the 15 Hz ERGs for flash strengths just above that of the minimum.

Mutations in TRPM1 are a common cause of complete congenital stationary night blindness.

Congenital stationary night blindness (CSNB) is a clinically and genetically heterogeneous group of retinal disorders characterized by nonprogressive impaired night vision and variable decreased visual acuity. We report here that six out of eight female probands with autosomal-recessive complete CSNB (cCSNB) had mutations in TRPM1, a retinal transient receptor potential (TRP) cation channel gene. These data suggest that TRMP1 mutations are a major cause of autosomal-recessive CSNB in individuals of European ancestry.

Nauseogenicity of off-vertical axis rotation vs. equivalent visual motion.

Introduction: Off-vertical axis rotation (OVAR) provokes motion sickness. The visual motion equivalent to OVAR in simulators is also nauseogenic. Our experiment compared the nauseogenicity of OVAR vs.