A pharmacy-led () chapter 800 compliance collaborative at an academic medical center.

Purpose: One academic medical center's efforts to move toward compliance with requirements of () chapter 800 through a multidepartmental collaborative initiative are described.

Summary: Requirements of general chapter 800 (enforceable as of December 2019) address the handling of hazardous drugs (HDs) throughout the entire operational and clinical cycle, from receiving to compounding, administration, and waste disposal. Due to the variety of pharmacy operational areas in which HDs are encountered at University of North Carolina Medical Center (UNCMC), multiple pharmacy managers oversee the safe handling of HDs.

Financial Effect of a Drug Distribution Model Change on a Health System.

Drug manufacturers change distribution models based on patient safety and product integrity needs. These model changes can limit health-system access to medications, and the financial impact on health systems can be significant. The primary aim of this study was to determine the health-system financial impact of a manufacturer's change from open to limited distribution for bevacizumab (Avastin), rituximab (Rituxan), and trastuzumab (Herceptin).