Publications by authors named "Bijan B Bairagya"
Background And Aim: IL28B gene polymorphisms have been associated with treatment-response (sustained virological response, SVR) in genotype 1 hepatitis C virus (HCV)-infected patients, but only with early phase of viral decline (rapid virological response, RVR) with genotype 3 HCV-infected patients. Association between IL28B variants and SVR in genotype 3 HCV- infected patients is unclear. Our study aimed to replicate the association of IL28Bsingle nucleotide polymorphism (SNP) rs8099917 with SVR and to validate its association with RVR in genotype 3 HCV-infected patients.
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- This study analyzed genetic diversity in 12 innate immune system genes among 171 individuals from eastern India, revealing a high level of novel DNA variants.
- Almost half of the 548 discovered DNA variants were new, and comparisons with reference sequences indicated signs of natural selection, likely due to the high pathogen exposure in the region.
- The study found significant differences in genetic variation compared to other populations, with innate immunity genes exhibiting a SNP density greater than the highest reported for any autosomal chromosome, highlighting the impact of natural selection on this population.