Therapeutic effects of CO2 laser therapy of linear nevus sebaceous in the course of the Schimmelpenning-Feuerstein-Mims syndrome.

The Schimmelpenning-Feuerstein-Mims (SFM) syndrome is a rare phakomatosis which comprises a nevus sebaceous of Jadassohn, seizures and developmental delay associated with a wide spectrum of extracutaneous abnormalities including neurological, skeletal, ocular, cardiovascular and urogenital defects. We are presenting a case of an 18-year-old patient with systemic features of the SFM syndrome and an extensive linear nevus sebaceous partially removed with a carbon dioxide (CO2) laser. The treatment options of skin lesions in patients with SFM are discussed.

[Inulin: a valuable nutritional component].

Inulin, a natural oligomer of fructose, is classified as a food component. It can be found in some plants and vegetables, i.e.

[Vitiligo as an aesthetic problem. Noninvasive therapeutic methods in vitiligo].

Vitiligo is an idiopathic chronic skin disease that is notable for depigmented macules forming by destruction of melanocytes mediated by cells of the immune system. Vitiligo occurs in 1-2% of the population irrespective of race and without predilection to gender or age. The dynamics and extent of the disease vary widely, ranging from stable cases with isolated minor foci to states showing rapid progression and occupying large areas of the skin.

[Antimalarial drugs in contemporary dermatologic therapy].

Antimalarial drugs--chloroquine, hydroxychloroquine and quinacrine, initially devised for the treatment of malaria, have been used in the therapy of diverse skin diseases, including lupus erythematosus, dermatomyositis, porphyria cutanea tarda, and sarcoidosis. The mechanism of action of these drugs involves stabilization of lysosomal enzymes, inhibition of antigen-presenting cells and T lymphocyte stimulation, blocking of the pro-inflammatory cytokine cascade and endosomal toll-like receptor signaling. The understanding of potential mechanisms of action of antimalarials may extend their use to new areas in dermatology.

[Sunscreens--chemical structure and application].

In the paper chemical structures and classification of active ingredients of sunscreens as physical or chemical filters are presented. Adequately selected to skin phototype sunscreen protects body against sunburn and prolonged sunlight exposure skin changes, induced by harmful ultraviolet radiation.

[The role of biological agents in dermatology].

Biological agents belong to a novel therapy method. Their immunomodulatory activity is used in treating some of the severe and chronic skin diseases. This paper presents the structure and activity of biological agents, enumerates preparations most commonly used in dermatology, their side effects and contraindications.

[Androgenetic alopecia in women as an aesthetic and psychological problem].

Androgenetic alopecia is a fairly common disorder which causes serious aesthetic and psychological problems. The paper discusses the etiology, diagnostics and possible treatment of androgenetic alopecia in women. Preparations for both general and external use in treatment of this dermatosis have been presented herein.

[Dry skin as a dermatological and cosmetic problem].

The paper presents current opinions on aetiopathogenesis of dry skin including its occurrence in the course of certain dermatological disorders. A meaning of natural moisturizing factor, lipid barrier as well as epidermal differentiation processes in the maintenance of the proper skin moisturization is described. The importance of topical treatment is emphasized.

[Retrospective analysis of adverse cutaneous drug reactions in patients hospitalized in Department of Dermatology and Venereology of Pomeranian Medical University in 1996-2006].

Introduction: Every adverse and undesirable event observed after administration of the therapeutic dose of the drug is defined as adverse drug reaction. The aim of the study was to evaluate the incidence frequency of cutaneous adverse drug reactions, to define the drugs inducing such reactions and to define the type of the most frequently found lesions in patients admitted to Department of Dermatology and Venereology of Pomeranian Medical University in Szczecin (PAM) in 1996-2006.

Material And Methods: A retrospective analysis of medical files of the patients, who were hospitalized in the Department of Dermatology and Venereology of PAM in Szczecin in 1996-2006, was carried out.

[Application of phototherapy in dermatology].

Phototherapy is nowadays one of the main methods used in dermatology. It can be used alone or in combination with oral and/or topical treatment. The action of ultraviolet radiation is exploited for the treatment of many diseases.

Acyclovir concentrations in the skin of humans after a single oral dose assessed by in vivo cutaneous microdialysis.

Background/purpose: Acyclovir is a synthetic deoxyguanosine analogue used in the treatment of certain viral diseases. This drug is effective primarily against Herpes simplex virus, Varicella zoster virus and to a lesser extent against Epstein-Barr virus and cytomegalovirus. The aim of the study was to determine the acyclovir concentrations in plasma and skin (cutaneous microdialysate) and to compare its penetration into real (skin) and theoretical peripheral compartment after administration of a single 0.

[Protection of the skin from harmful ultraviolet radiation].

Ultraviolet radiation from the sun or artificial sources can exert beneficial and/or damaging effect on human skin. Excessive UV radiation has been implicated in the increased incidence of skin malignancies and accelerated skin photoaging. Thus, the skin requires adequate protection and sunscreens are useful for this purpose.

Penetration of cotrimoxazole components into skin after a single oral dose. Theoretical versus experimental approach.

Concentrations of trimethoprim and sulfamethoxazole in plasma, cantharidin-induced skin blister fluid and theoretical peripheral compartment were determined in twelve male subjects suffering from bacterial skin diseases after a single oral dose of 0.32 g of trimethoprim and 1.6 g of sulfamethoxazole.

Germline mutation and large deletion analysis of the CDKN2A and ARF genes in families with multiple melanoma or an aggregation of malignant melanoma and breast cancer.

The CDKN2A/ARF genes have been associated with increased risk of malignant melanoma (MM) in families with multiple members affected by disease and in families characterized by the constellation of breast cancer and MM. The exact contribution of CDKN2A/ARF to disease risk remains poorly characterized, especially in diverse populations. In this report, the contribution of CDKN2A/ARF germline mutations and large rearrangements to disease in Polish familial MM (FMM) and aggregations of breast cancer and MM were assessed using a strategy that included genomic sequencing, restriction fragment length polymorphism and multiplex ligation-dependent probe amplification.

Use of an intraluminal guide wire in linear microdialysis probes: effect on recovery?

Background/purpose: For microdialysis studies in the skin, laboratory-made linear probes are often used. Probes can be assembled with or without a stainless-steel guide wire in the lumen of the dialysis fibre. From a theoretical viewpoint, this will alter the performance of the probe.

Evaluation of ofloxacin penetration into the skin after a single oral dose assessed by cutaneous microdialysis.

An antibacterial drug can exert its therapeutic action if it is present in target tissue at proper concentration. Cutaneous microdialysis is a relatively new technique, which allows to determine drug concentration in the skin. The aim of the study was to evaluate the ofloxacin concentrations in plasma and skin following a single oral dose of 0.

A simple and rapid liquid chromatographic method for the determination of metronidazole and its hydroxymetabolite in plasma and cutaneous microdialysates.

A rapid, accurate, simple and low-cost method for quantitative determination of metronidazole and its hydroxymetabolite, in plasma and microdialysate samples, using tinidazole as an internal standard, has been developed. Metronidazole is widely used as a valuable agent for antiprotozoal as well as antibiotic therapy when anaerobic organisms are involved. Separation of the compounds studied was performed on a 120 x 4 mm analytical column, filled with LiChrosorb RP-8, 5 microm, the mobile phase consisted of 0.