Bilateral decrease in interictal hippocampal blood flow in unilateral mesiotemporal epilepsy.

Object: The goal of this study was to determine whether regional cerebral blood flow (rCBF) changes that were found contralaterally to a verified unilateral epileptic focus were associated with the spatiotemporal organization of epileptic abnormalities.

Methods: The CBF in both hippocampi was assessed using stable Xe-enhanced computerized tomography in a series of 19 patients with unilateral mesiotemporal epilepsy. Results were compared according to the distribution of interictal spiking and the spatiotemporal organization of the ictal discharges as determined by stereoelectroencephalography.

Regional cerebral blood flow measurements with Xenon-CT in the prediction of delayed encephalopathy after carbon monoxide intoxication.

Reported evaluations of CBF with Xe/CT were performed in 11 patients during the lucid interval following CO intoxication. Results were compared with clinical and SPECT data. Two patients developed neuropsychiatric behavior (delayed encephalopathy) one month following the initial recovery.

Lysolecithin-induced demyelination in primates: preliminary in vivo study with MR and magnetization transfer.

Purpose: To study bystander demyelination in multiple sclerosis with an experimental in vivo model of toxic demyelination.

Methods: Toxic demyelinating lesions were created in two monkeys by injection of lysophosphatidylcholine in the centrum semiovale. Follow-up was done clinically and with serial MR studies, including T2-weighted and gadolinium-enhanced T1-weighted images and measurement of magnetization transfer ratio, until the animals were killed at days 14 and 34, respectively.

Effects of nimodipine on posttraumatic spinal cord ischemia in baboons.

Posttraumatic ischemia appears to be largely responsible for the extension of lesions in acute injury of the spinal cord. In the present study, we have evaluated the putative improvement of axonal function by the calcium channel blocker nimodipine after acute trauma of the spinal cord. Three techniques were used: (1) spinal cord blood flow (SCBF) using a scanographic technique with stable xenon, (2) somatosensory evoked potentials (SEPs), and (3) magnetic resonance imaging (MRI).

[Methods for measuring spinal cord blood flow].

This study aimed to review the techniques used most currently for measuring spinal cord blood blow flow (SCBF) in animals, i.e. the hydrogen clearance, labelled microspheres, 133Xe clearance and 14C-antipyrine autoradiographic methods.

[CT X-ray measurement of cerebral blood flow by stable xenon. Methodology and applications].

The measurement of cerebral blood flow by stable xenon computerized tomography is a tridimensional method that offers an excellent spatial resolution. The quantitative estimation of the cerebral blood flow is based on Fick's principle, transformed by Kety and Schmidt, using stable xenon as indicator, which is an inert and freely diffusible gas. The limitations of this method are related to the necessity for the patient to remain completely immobile during the examination, the low signal/noise ratio and the impossibility of measuring cerebral metabolism.

[Protocol for preparation, anesthesia and monitoring in therapeutic angiography].

The procedures involved in cerebral and medullary embolization produce special problems for the anesthesiologist. Some imperatives must be followed in order to minimize the high neuroradiological risks associated with these long and repetitive procedures. The first of these imperatives is sedation, which throughout the procedure should be sufficient, although not narcotic enough to prevent neurological evaluations.

Measurement of cerebral blood flow by the stable xenon computerized tomography method.

Measurement of cerebral blood flow (CBF) by computerized tomography (CT) is a three-dimensional method with better spatial resolution than the two-dimensional methods. Its principle was first described by Drayer et al. in 1978, with stable xenon (Xes) as CBF indicator.

[Bilateral choanal atresia in the newborn infant. Role of the anesthesiologist].

Congenital bilateral atresia of the choana is a rare anomaly. It is a closure of the posterior nares by a membranous and/or osseous partition. It causes early respiratory distress in the neonate.

Double-blind study of effects of enkephalinase inhibitor on adverse reactions to myelography.

The side effects in myelography are well known and frequently observed. The most common are headache, nausea, and vomiting. In this study, a rather new compound, Thiorphan, was examined, which displays an antinociceptive activity by inhibiting enkephalinase activity.