Publications by authors named "Bich Tram Duong"
Article Synopsis
- 6-Meraptopurine (6-MP) is a key drug for maintaining treatment in children with acute lymphoblastic leukemia (ALL), and its metabolism is influenced by specific genetic variants in the Asian population.
- A study of 102 children found that those with certain genetic mutations (especially the c.415C>T variant) had significantly higher rates of neutropenia (low white blood cell count) during the first 3 months of treatment compared to normal metabolizers.
- The research suggests that about 25% of the participants had mutations affecting 6-MP metabolism, highlighting the need for genetic testing to optimize treatment doses for better patient outcomes.
