Publications by authors named "Bich N Bui"
Article Synopsis
- This study looked at why some good-quality embryos fail to implant after IVF, by examining the endometrial tissue (the lining of the uterus) of women who had unsuccessful cycles.
- Scientists collected samples from 107 women and used special techniques to analyze the genes in the endometrium to see if they could predict whether the embryos would successfully implant or not.
- They found that understanding the gene activity in the uterus could help make better decisions for treating infertility in the future.
Infertility is a complex condition affecting millions of couples worldwide. The current definition of infertility, based on clinical criteria, fails to account for the molecular and cellular changes that may occur during the development of infertility. Recent advancements in sequencing technology and single-cell analysis offer new opportunities to gain a deeper understanding of these changes.
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- The study investigates how steroid concentrations in endometrial tissue and serum relate to gene expression of steroid-metabolizing enzymes to assess endometrial receptivity in IVF patients.
- It involves a case-control design with 40 IVF patients, comparing 20 women who achieved clinical pregnancy to 20 who did not, while controlling for various factors like fertility type and age.
- Results show no overall differences in steroid levels between pregnant and nonpregnant groups, but pregnant women with primary infertility had lower estrone levels and a distinct estrone:androstenedione ratio compared to their nonpregnant counterparts.
The endometrial microbiota composition may be associated with implantation success. However, a 'core' composition has not yet been defined. This exploratory study analysed the endometrial microbiota by 16S rRNA sequencing (V1-V2 region) of 141 infertile women whose first IVF/ICSI cycle failed and compared the microbiota profiles of women with and without a live birth within 12 months of follow-up, and by infertility cause and type.
View Article and Find Full Text PDFEndometrial injury for pregnancy following sexual intercourse or intrauterine insemination.
Cochrane Database Syst Rev
October 2022
Background: Intentional endometrial injury is being proposed as a technique to improve the probability of pregnancy in women undergoing assisted reproductive technologies (ART) such as in vitro fertilisation (IVF). Endometrial injury is often performed by pipelle biopsy and is a common gynaecological procedure with established safety. However, it causes a moderate degree of discomfort/pain and requires an additional pelvic examination.
View Article and Find Full Text PDFEndometrial injury for pregnancy following sexual intercourse or intrauterine insemination.
Cochrane Database Syst Rev
March 2021
Background: Intentional endometrial injury is being proposed as a technique to improve the probability of pregnancy in women undergoing assisted reproductive technologies (ART) such as in vitro fertilisation (IVF). Endometrial injury is often performed by pipelle biopsy and is a common gynaecological procedure with established safety. However, it causes a moderate degree of discomfort/pain and requires an additional pelvic examination.
View Article and Find Full Text PDFResearch Question: Can organoids be established from endometrial tissue of infertile women and does tissue cryopreservation allow for establishment of organoids comparable to organoids derived from freshly biopsied endometrial tissue?
Design: Endometrial tissue was obtained from six infertile women through minimally invasive biopsy using a Pipelle catheter and subjected to organoid development, immediately after biopsy as well as after tissue cryopreservation. Organoid formation efficiency, morphology, expandability potential, endometrial marker expression (immunostaining and reverse transcription quantitative real-time polymerase chain reaction) and hormonal responsiveness (after oestradiol and progesterone treatment) were assessed.
Results: Organoids established from both fresh and frozen tissue at comparable efficiency could be passaged long-term and showed similar morphology, i.
Introduction And Hypothesis: The treatment of post-hysterectomy vaginal vault prolapse (VVP) has been investigated in several randomized clinical trials (RCTs), but a systematic review of the topic is still lacking. The aim of this study is to compare the effectiveness of treatments for VVP.
Methods: We performed a systematic review and meta-analysis of the literature on the treatment of VVP found in PubMed and Embase.