A new class of penicillin-binding protein inhibitors to address drug-resistant .

β-Lactams are the most widely used antibiotics for the treatment of bacterial infections because of their proven track record of safety and efficacy. However, susceptibility to β-lactam antibiotics is continually eroded by resistance mechanisms. Emerging multidrug-resistant (MDR) strains possessing altered alleles (encoding PBP2) pose a global health emergency as they threaten the utility of ceftriaxone, the last remaining outpatient antibiotic.

Effectiveness of Butorphanol in alleviating intra- and post-operative visceral pain following microwave ablation for hepatic tumor: a dual-central, randomized, controlled trial.

Many patients who underwent hepatic percutaneous microwave ablation (MWA) reported experiencing pain during the procedure. This study utilized a well-designed multicentral, randomized, and placebo-controlled format to investigate the effects of Butorphanol. Patients who underwent MWA were randomly assigned to either Butorphanol or normal saline group.

Self-Supplied Reactive Oxygen Species-Responsive Mitoxantrone Polyprodrug for Chemosensitization-Enhanced Chemotherapy under Moderate Hyperthermia.

Currently, the secondary development and modification of clinical drugs has become one of the research priorities. Researchers have developed a variety of TME-responsive nanomedicine carriers to solve certain clinical problems. Unfortunately, endogenous stimuli such as reactive oxygen species (ROS), as an important prerequisite for effective therapeutic efficacy, are not enough to achieve the expected drug release process, therefore, it is difficult to achieve a continuous and efficient treatment process.

Balance of Gata3 and Ramp2 in hepatocytes regulates hepatic vascular reconstitution in postoperative liver regeneration.

Background & Aims: Post-hepatectomy liver failure (PHLF) leads to poor prognosis in patients undergoing hepatectomy, with hepatic vascular reconstitution playing a critical role. However, the regulators of hepatic vascular reconstitution remain unclear. In this study, we aimed to investigate the regulatory mechanisms of hepatic vascular reconstitution and identify biomarkers predicting PHLF in patients undergoing hepatectomy.

Synergistic effects of core-shell structured piperazine pyrophosphate microcapsules on fire safety and mechanical property in styrenic thermoplastic elastomer.

In this study, core-shell structured piperazine pyrophosphate (PAPP) is designed to enhance the fire safety and mechanical property of styrenic thermoplastic elastomer (TPE) composites. The PAPP is microencapsulated with carbon nanotube modified melamine-formaldehyde resin to prepare core-shell structured flame retardants (MT@PAPP). Due to the excellent compatibility between the MT@PAPP and TPE matrix, the mechanical property of TPE/MT@PAPP is improved.

A novel ROS-activable self-immolative prodrug for tumor-specific amplification of oxidative stress and enhancing chemotherapy of mitoxantrone.

Reactive oxygen species (ROS) as well-known endogenous stimuli has been widely used to activate drug delivery systems (DDSs) for tumor-specific therapy. Unfortunately, endogenous ROS in the tumor microenvironment (TME) is not enough to achieve effective therapeutic efficacy and cancer cells have adapted to high oxidative stress by upregulating glutathione (GSH) level. Herein, we devised a novel ROS-activable self-immolative prodrug CASDB with both GSH-depletion ability and ROS self-supply competence.

ITCH facilitates proteasomal degradation of TXNIP in hypoxia- induced lung cancer cells.

Background: Lung cancer (LC) is one of the most common cancers and a leading cause of cancer-related deaths worldwide. In many pathological conditions, particularly in the tumor microenvironment, cells and tissues frequently exist in a hypoxic state. Here, we evaluated Itchy E3 ubiquitin protein ligase (ITCH) expression in LC cells following hypoxia treatment.

Hierarchical TiCT@BPA@PCL for flexible polyurethane foam capable of anti-compression, self-extinguishing and flame-retardant.

It is of great importance to fabricate flexible polyurethane foam (FPUF) with superior mechanical properties and flame retardancy for practical applications. Herein, organosilicon and phenyl phosphorus compounds were synthesized and grafted on the surface of TiCT (TiCT@BPA@PCL) via in-situ polymerization. Then, the FPUF composites were fabricated, combining intrinsic flame retardancy (9,10-dihydro-9-oxa-10-phosphaphenanthrene 10-oxide-diethanolamine: DH-DOPO) (addition amount: 20 wt%) and TiCT@BPA@PCL (addition amount: 4 wt%).

PHF5A promotes colorectal cancerprogression by alternative splicing of TEAD2.

Dysregulated alternative splicing (AS) plays critical roles in driving cancer progression, and the underlying mechanisms remain largely unknown. Here, we demonstrated that PHF5A, a component of U2 small nuclear ribonucleoproteins, was frequently upregulated in colorectal cancer (CRC) samples and associated with poor prognosis. PHF5A promoted proliferation and metastasis of CRC cells and .

Anti-Fogging, Frost-Resistant transparent and flexible silver Nanowire-TiCT MXene based composite films for excellent electromagnetic interference shielding ability.

The development of electronics proposes higher requirements for flexible, transparent, and conductive materials with high electromagnetic shielding performance in viewing windows. Flexible transparent films have been fabricated by collaborating one-dimensional silver nanowires (AgNWs) and novel two-dimensional TiCT MXene sheets on PET films with an external polymeric coating consisting of poly (vinyl alcohol) (PVA) and poly(styrene sulfonate) (PSS). Especially, the combination of different dimensional nanomaterials effectively establishes a conductive network that exhibits a synergistic effect on excellent electromagnetic interference (EMI) shielding performance, which is superior to that of pure AgNW network or TiCT network to some extent.

The ReSnO (Re = Nd, Sm, Gd) on the enhancement of fire safety and physical performance of Polyolefin/IFR cable materials.

Polyolefin (PO) cables used in confined spaces need to have low smoke, low heat release, low toxic gas release and excellent physical properties. In this work, a series of rare earth stannates ReSnO (RES, Re = Nd, Sm, Gd) with high temperature catalytic performance were prepared by hydrothermal method for synergistic flame retardant PO/IFR. The flame retardancy, heat release, smoke density, toxic gas release and physical properties of PO composites were thoroughly studied in detail.

Functionalizing TiCT for enhancing fire resistance and reducing toxic gases of flexible polyurethane foam composites with reinforced mechanical properties.

Flexible polyurethane foam (FPUF) is the most used polyurethane, but the highly flammable characteristic limits its widespread usage. In this work, ZIF-8@TiCTwas synthesized to reduce the heat and toxic gases of FPUF. Flame-retardant FPUF was characterized by cone calorimeter (Cone), thermogravimetric analysis/fourier-transform infrared spectroscopy (TG-FTIR), tensileand compression tests.

Design of copper salt@graphene nanohybrids to accomplish excellent resilience and superior fire safety for flexible polyurethane foam.

Flexible polyurethane foam (FPUF) is the most commonly used polyurethane, but its highly flammable characteristics makes it ignite easily and release a lot of heat and toxic gases. Here, the effect of different forms of copper salt modified graphene (rGO@CuO, rGO@CuO and rGO@CSOH) on improving the fire protection efficiency and mechanical property of FPUF is explored. Hybrid FPUF is characterized by thermogravimetric analysis (TGA), cone calorimeter, thermogravimetric analysis/Fourier transform infrared spectroscopy (TG-IR), tension, compression, and falling ball rebound testing.

The improvement of fire safety performance of flexible polyurethane foam by Highly-efficient P-N-S elemental hybrid synergistic flame retardant.

Herein, three different phosphorus-containing compounds (methyl phosphoryl dichloride, phenyl phosphoryl dichloride and phenyl dichlorophosphate) were reacted with 2-aminobenzothiazole respectively, and a series of synergistic flame retardants with phosphorus, nitrogen and sulfur elements were synthesized, named MPBT, PPBT and POBT respectively. Then, they were added to prepare flame-retardant flexible polyurethane foam (FPUF). Through the analysis of thermal stability, pyrolysis, heat release and smoke release behavior, the influence of different phosphorus-containing structures on the flame-retardant performance of FPUF was studied, and their flame-retardant mechanism was explored in detail.

A facile strategy for lightweight, anti-dripping, flexible polyurethane foam with low smoke emission tendency and superior electromagnetic wave blocking.

Flexible polyurethane foam (FPUF) has been considered as an excellent material in many fields, such as furniture and electromagnetic interference (EMI) shielding products due to its lightweight and flexibility. However, there is a severe fire hazard problem for FPUF that makes it unsuitable to be used in practical. Herein, a facile method was to prepare anti-dripping FPUF via electroless plating at ambient temperature.

Durable electromagnetic interference (EMI) shielding ramie fabric with excellent flame retardancy and Self-healing performance.

Although more and more attention has been paid to electromagnetic interference (EMI) shielding fabric materials due to increasing electromagnetic waves pollution, little attention to their fire safety behavior and durability in practical use. Herein, durable EMI shielding ramie fabric with flame retardant and self-healing performance were fabricated by depositing ammonium polyphosphate (APP)/polyethyleneimine (PEI) layer, MXene sheets and polycaprolactone (PCL) layer. The resultant multifunctional fabric could self-extinguish and the peak heat release rate (pHRR) value reduced about 74.

Prediction of Pretreatment 18F-FDG-PET/CT Parameters on the Outcome of First-Line Therapy in Patients with Metastatic Breast Cancer.

Objective: 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) can provide prognostic information, especially 18F-FDG uptake has been proven to be a predictor for the prognosis of various tumors. Nevertheless, the prognosis of other PET parameters in the metastatic setting remains unclear. This study was aimed at investigating pretreatment parameters based on 18F-FDG-PET/CT so as to estimate the progression-free survival (PFS) of metastatic breast cancer (MBC) patients receiving first-line treatment.

MT1JP-mediated miR-24-3p/BCL2L2 axis promotes Lenvatinib resistance in hepatocellular carcinoma cells by inhibiting apoptosis.

Purpose: Lenvatinib is a long-awaited alternative to Sorafenib for first-line targeted therapy of patients with advanced hepatocellular carcinoma (HCC). However, resistance to Lenvatinib results in tumor progression and has become a major obstacle to improving the prognosis of HCC patients. Exploring the mechanisms underlying Lenvatinib resistance is considered essential for the treatment of advanced HCC.

Self-healable castor oil-based waterborne polyurethane/MXene film with outstanding electromagnetic interference shielding effectiveness and excellent shape memory performance.

Recently, the increasing demands of the portable devices and flexible electronics have caused lots of electromagnetic wave pollution. MXene, a novel two-dimensional material, was considered as a promising two-dimensional material for preparing flexible electromagnetic interference (EMI) shielding films. Herein, we firstly synthesized a series of flexible and self-healable EMI shielding waterborne polyurethane (ADWPU) films by mechanically blending with TiCT (ADWPU-T).

High Serum Levels of Cholesterol Increase Antitumor Functions of Nature Killer Cells and Reduce Growth of Liver Tumors in Mice.

Background And Aims: The relationship between serum cholesterol level and development of hepatocellular carcinoma (HCC) remains unclear. We investigated the effects of serum cholesterol level on development of liver tumors in mice.

Methods: We performed studies with C57BL/6J mice, mice with disruption of the low-density lipoprotein receptor gene (Ldlrmice), and mice with conditional deletion of nature killer (NK) cells (NK mice).

Nacre-Inspired Tunable Electromagnetic Interference Shielding Sandwich Films with Superior Mechanical and Fire-Resistant Protective Performance.

With the rapidly increasing development of portable device hardware and flexible electronics, ultrathin electromagnetic interference (EMI) shielding films with a combination of high flexibility and excellent mechanical properties are noticeably required. In addition to minimizing the electromagnetic wave pollution problem, the fire hazards caused by accidental electrical leakage or aging are also a cause of extensive concern. Inspired by nacre and sandwich structure, herein, we fabricated for the first time an electrical insulating sandwich-structured film based on Ca ion cross-linked sodium alginate (SA)-montmorillonite (MMT) and TiCT MXene through a step-by-step vacuum-assisted filtration process.

Natural antioxidant functionalization for fabricating ambient-stable black phosphorus nanosheets toward enhancing flame retardancy and toxic gases suppression of polyurethane.

Herein, as a natural antioxidant, tannin (TA) is firstly used to functionalize black phosphorous (BP) nanosheets to improve the ambient stability and toxic suppression, thus decreasing the fire hazards of polymer materials. Compared to pure BP nanosheets, higher temperature for thermal oxidation decomposition is achieved for TA-BP nanosheets, directly confirming the ambient stability of TA-BP nanosheets. Meanwhile, from high resolution TEM and XPS results, TA-BP nanosheets after being exposed at air for 10 days present well-organized crystal structure and low PO bonds content.

[Outcome of corrective osteotomy of shortened medial foot column after old talar neck fracture].

Objective: To investigate the effectiveness of corrective osteotomy for shortened medial foot column after old talar neck fracture.

Methods: The clinical data of 10 patients with shortened medial foot column after old talar neck fracture between June 2012 and May 2017 was retrospectively analyzed. There were 7 males and 3 females with an average age of 45.