Publications by authors named "Bibin T Varghese"
Article Synopsis
- TTN encodes the protein titin and is commonly associated with rare variants in patients diagnosed with atrial fibrillation (AF) during genetic testing.
- The study compared characteristics and outcomes of patients with AF having pathogenic TTN variants to those without such variants, revealing that TTN(+) patients experience more persistent AF and require more cardioversions.
- Findings indicate that nearly 50% of TTN(+) AF patients develop serious heart issues, emphasizing the importance of specialized evaluation and management for these individuals.
Article Synopsis
- * A study involving 1,366 participants found that while having a pathogenic variant in any CM or arrhythmia gene wasn't significantly linked to AF recurrence, variants in the ALVC gene group (especially LMNA) were associated with a higher risk.
- * Overall, AF ablation appears beneficial for most patients with these variants, but those with ALVC variants may face a greater chance of experiencing recurrence of arrhythmias.
Background: Recurrence after atrial fibrillation (AF) ablation remains common. We evaluated the association between recurrence and levels of biomarkers of cardiac remodeling, and their ability to improve recurrence prediction when added to a clinical prediction model.
Methods And Results: Blood samples collected before de novo catheter ablation were analyzed.
While the field of polymer mechanochemistry has traditionally focused on the use of mechanical forces to accelerate chemical processes, theoretical considerations predict an underexplored alternative: the suppression of reactivity through mechanical perturbation. Here, we use electronic structure calculations to analyze the mechanical reactivity of six mechanophores, or chemical functionalities that respond to mechanical stress in a controlled manner. Our computational results indicate that appropriately directed tensile forces could attenuate (as opposed to facilitate) mechanochemical phenomena.
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