Publications by authors named "Bibiana Sampaio de Oliveira Fam"
Genet Mol Biol
November 2023
Article Synopsis
- This study looks at special protein variants in primates related to the AVPR2 receptor, which helps manage water in the body.
- The researchers found that some parts of this protein show changes that might help explain a rare kidney problem in humans that causes too much water loss.
- They also discovered that how these proteins evolved is linked to other important proteins, but the changes didn’t seem to depend on the different climates where these primates live.
Infect Genet Evol
November 2021
Article Synopsis
- STAT2 plays a crucial role in the immune response to viral infections, especially following type I interferon release, but many flaviviruses attack and impair STAT2 to weaken this defense.
- A study analyzed the STAT2 coding sequences from 28 rodent species and 49 primate species, finding various sites influenced by positive selection, particularly in relation to susceptibility to flavivirus infections.
- Results indicate that certain positively selected sites in the STAT2 gene contribute to the protein's stability and interaction with a flavivirus protein, suggesting that rodents may have a slight evolutionary edge over primates in defending against these viruses due to faster evolutionary rates.
