Hepatic encephalopathy and other neurodegenerative disorders have profound implications for extensive liver impairment, calling for new ways of treating the condition. The application of stem cell transplantation to treat these severe disorders is a new and encouraging technique. This review article digs deep into the subject of stem cell transplantation therapy, neurodegenerative disorders associated with advanced liver damage, and liver transplantation.
View Article and Find Full Text PDFCitation of the publication (our own previous work), Yaseen, M [...
View Article and Find Full Text PDFA pot experiment was conducted to investigate the role of thiourea exogenous application (0 mg/L and 100 mg/L) on the morphological, physiological, and yield traits of two varieties of tomato (Naqeeb and Nadir) under different salt stress treatments (0, 60, and 120 mM) in completely randomized design (CRD). The imposition of salinity by rooting medium showed that salt stress reduced plant height by 20%, fresh shoot weight by 50%, dry shoot weight by 78%, fresh root weight by 43%, dry root weight by 84%, root length by 34%, shoot length by 32%, shoot K by 47%, Ca by 70%, chlorophyll a by 30%, chlorophyll b by 67%, and the number of seeds per berry by 53%, while shoot Na ions were increased by 90% in comparison to those grown with control treatment. However, the exogenous application of thiourea significantly enhanced dry root weight by 25% and the number of seeds per berry by 20% in comparison to untreated plants with thiourea when grown under salt stress.
View Article and Find Full Text PDFObjectives: To identify demographic, clinical and immunological factors associated with adverse COVID-19 outcomes.
Methods: A large randomised controlled trial of ChAdOx1 nCoV-19 was undertaken in Brazil. Participants were randomised 1:1 either to receive ChAdOx1 nCov-19 or to a control group.
Background: Enhanced Recovery After Surgery (ERAS) protocols were progressively implemented to advance postoperative results in various surgical specialties. However, their effectiveness in general surgical patients remains underexplored. This study intended to assess impact of ERAS protocols on postoperative results in general surgical patients at Jinnah International Hospital Abbottabad (JIHA).
View Article and Find Full Text PDFA large amount of marble powder is abundantly available as a byproduct and waste in the marble industry, and its reinforcement has been attempted in several applications through surface modification. This article examines the use of MP in the production of rubber, paper, foam stabilizers, asphalt, paint, textiles, and adhesives. This article aims to provide a foundation for the surface modification of MP to enhance its properties and broaden its range of applications.
View Article and Find Full Text PDFChitosan (Cs), a naturally occurring biopolymer, has garnered significant interest due to its inherent biocompatibility, biodegradability, and minimal toxicity. This study investigates the effectiveness of various reaction strategies, including acylation, acetylation, and carboxymethylation, to enhance the solubility profile of Cs. This review provides a detailed examination of the rapidly developing field of Cs-based metal complexes and nanoparticles.
View Article and Find Full Text PDFUnlabelled: Policy Points What are the facilitators and barriers of physician group participation in a performance-based financial incentive program aimed at improving equity of care by patient race and ethnicity? Launching financial incentives to improve racial equity has required extensive organizational change management for participating physician groups, including major investments to improve quality management systems. Carefully designing financial incentives to encourage equity improvement while managing unintended consequences, and considering physician groups' populations served, baseline maturity of quality management systems, and efforts to assess and address patients' social risk factors have been central to prepare physician groups for financial incentives to improve equity of care. Given the major investments required of physician groups to prepare for financial incentives that reward equity improvement, alignment of equity of care measure specifications and reporting requirements across payers could facilitate physician group engagement.
View Article and Find Full Text PDFInt J Biol Macromol
November 2024
Siglec-9 is a promising immune checkpoint molecule, and therapeutics targeting Siglec-9 have the potential to augment anti-tumor immunity. Here, we generated a bispecific antibody, named as aSE4-1-Fc, by fusing two distinct alpaca derived nanobodies, which can simultaneously target the extracellular Ig variable (V)-set domain and C2-set domains of murine Siglec-9 (also known as Siglec-E) with high affinity. In vivo studies showed that aSE4-1-Fc was better than its component antibodies in inhibiting tumor growth/metastasis, and Siglec-E blockade using aSE4-1-Fc generated protective anti-tumor T cell memory.
View Article and Find Full Text PDFBackground: Bordetella pertussis continues to cause whooping cough globally even in countries with high immunisation coverage. Booster vaccinations with acellular pertussis vaccines are thus used in children, adolescents, and adults. T cell immunity is crucial for orchestrating the immune response after vaccination.
View Article and Find Full Text PDFBabesia (B.) microti is an intra-erythrocytic protozoan parasite that infects humans as well as domestic and wild animals. Prevalence of B.
View Article and Find Full Text PDFAchieving high power conversion efficiency (PCE) remains a significant challenge in the advancement of organic solar cells (OSCs). In the field of organic photovoltaics (OPVs), considerable progress has been made in optimizing molecular structures to improve the PCE. However, innovative material design strategies specifically aimed at enhancing PCE are still needed.
View Article and Find Full Text PDFBackground: Geranyl acetate, a compound found in plant oils, has been studied for its potential effects on renal and cardiovascular ailments.
Objective: This study aimed to investigate the diuretic and anti-hyperuricemic properties of geranyl acetate in male Wistar rats using a hyperuricemia-induced rat model.
Methods: Molecular docking studies were conducted to assess geranyl acetate's interactions with various targets.
Background: Endemic fluorosis refers to the condition when individuals are exposed to excessive amounts of fluoride ion due to living in a region characterized by elevated levels of fluorine in the drinking water, food, and/or air. In Pakistan, a substantial proportion of the population is thereby affected, posing a public health concern.
Objectives: Assessing how the gut microbiota and its metabolic profiles are impacted by chronic exposure to fluoride in drinking water (that caused Dental Fluorosis) as well as to perceive how this microbiota is connected to adverse health outcomes prevailing with fluoride exposure.
Antimetabolites are the most effective chemotherapeutics for treating cancer. They have exerted their anticancer effects by interfering with DNA synthesis. Recently, interest in modified nucleoside analogues has grown due to their superior efficiency.
View Article and Find Full Text PDFHuntington's disease (HD) is a gradually severe neurodegenerative ailment characterised by an increase of a specific trinucleotide repeat sequence (cytosine-adenine-guanine, CAG). It is passed down as a dominant characteristic that worsens over time, creating a significant risk. Despite being monogenetic, the underlying mechanisms as well as biomarkers remain poorly understood.
View Article and Find Full Text PDFEthnopharmacological Relevance: The traditional use of plants for medicinal purposes, called phytomedicine, has been known to provide relief from pain. In Bangladesh, the Chakma indigenous community has been using Allophylus villosus and Mycetia sinensis to treat various types of pain and inflammation.
Aim Of The Study: The object of this research is to evaluate the effectiveness of these plants in relieving pain and their antioxidant properties using various approaches such as in vitro, in vivo, and computational techniques.
Background: The Scutellaria genus has promising therapeutic capabilities as an aromatherapy. Based on that and local practices of S. nuristanica Rech.
View Article and Find Full Text PDFObjective: To determine the auxological response to recombinant human growth hormone (rhGH) therapy in children with growth hormone deficiency (GHD) presenting at the National Institute of Child Health, Karachi, Pakistan.
Study Design: Observational study. Place and Duration of the Study: Department of Paediatric Endocrinology, National Institute of Child Health, Karachi, Pakistan, from January 2022 to December 2023.
Mol Plant Microbe Interact
October 2024